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    GP2 glycoprotein 2 [ Homo sapiens (human) ]

    Gene ID: 2813, updated on 9-Dec-2024

    Summary

    Official Symbol
    GP2provided by HGNC
    Official Full Name
    glycoprotein 2provided by HGNC
    Primary source
    HGNC:HGNC:4441
    See related
    Ensembl:ENSG00000169347 MIM:602977; AllianceGenome:HGNC:4441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAP75
    Summary
    This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Restricted expression toward pancreas (RPKM 2558.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GP2 in Genome Data Viewer
    Location:
    16p12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (20309574..20327513, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (20240526..20258466, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20320896..20338835, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723396 Neighboring gene SNRPE pseudogene 3 Neighboring gene uromodulin Neighboring gene protein disulfide isomerase like, testis expressed Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:20397845-20398378

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Meta-analysis identifies common variants associated with body mass index in east Asians.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp779K0533

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within antigen transcytosis by M cells in mucosal-associated lymphoid tissue ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in zymogen granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    pancreatic secretory granule membrane major glycoprotein GP2
    Names
    glycoprotein 2 (zymogen granule membrane)
    pancreatic zymogen granule membrane associated protein GP2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007240.3NP_001007241.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001007241.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC106796
      Consensus CDS
      CCDS42128.1
      UniProtKB/Swiss-Prot
      A6NFM9, A6NJA8, P55259, Q13338, Q9UIF1
      UniProtKB/TrEMBL
      B2R5R0
      Related
      ENSP00000370767.4, ENST00000381362.8
      Conserved Domains (2) summary
      smart00241
      Location:229480
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:358478
      Zona_pellucida; Zona pellucida-like domain
    2. NM_001007241.3NP_001007242.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001007242.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AC106796
      Consensus CDS
      CCDS45433.1
      UniProtKB/TrEMBL
      Q8N1A3
      Related
      ENSP00000370765.5, ENST00000381360.9
      Conserved Domains (2) summary
      smart00241
      Location:82333
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:211331
      Zona_pellucida; Zona pellucida-like domain
    3. NM_001007242.3NP_001007243.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001007243.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The resulting protein (isoform 4, also known as beta) is shorter than isoform 1.
      Source sequence(s)
      AC106796
      Consensus CDS
      CCDS45432.1
      UniProtKB/TrEMBL
      Q8N1A3
      Related
      ENSP00000343861.5, ENST00000341642.9
      Conserved Domains (2) summary
      smart00241
      Location:79330
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:208328
      Zona_pellucida; Zona pellucida-like domain
    4. NM_001502.4NP_001493.2  pancreatic secretory granule membrane major glycoprotein GP2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001493.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2, also known as alpha) is shorter than isoform 1.
      Source sequence(s)
      AC106796
      Consensus CDS
      CCDS10582.2
      UniProtKB/TrEMBL
      B2R5R0
      Related
      ENSP00000304044.6, ENST00000302555.10
      Conserved Domains (2) summary
      smart00241
      Location:226477
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:355475
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      20309574..20327513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      20240526..20258466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)