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    SCAI suppressor of cancer cell invasion [ Homo sapiens (human) ]

    Gene ID: 286205, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SCAIprovided by HGNC
    Official Full Name
    suppressor of cancer cell invasionprovided by HGNC
    Primary source
    HGNC:HGNC:26709
    See related
    Ensembl:ENSG00000173611 MIM:619222; AllianceGenome:HGNC:26709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET40; C9orf126
    Summary
    This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in brain (RPKM 4.6), lung (RPKM 2.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SCAI in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124942608..125143528, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137140969..137341870, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127704887..127905807, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene golgin A1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20274 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene protein phosphatase 6 catalytic subunit Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer. Gasparics Á, et al. Pathol Oncol Res, 2018 Jul. PMID 28815470
    2. Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI. Cai Y, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 33327889, Free PMC Article
    3. Characterization and Genomic Localization of a SMAD4 Processed Pseudogene. Watson CM, et al. J Mol Diagn, 2017 Nov. PMID 28867604
    4. Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell Migration and Invasion of Osteosarcoma by Directly Targeting SCAI. Wang JW, et al. Oncol Res, 2019 Sep 23. PMID 30180920, Free PMC Article
    5. MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI. Yi T, et al. Biomed Pharmacother, 2019 Jan. PMID 30551495

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI.
      Title: Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI.
    2. Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7.
      Title: Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7.
    3. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
      Title: The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
    4. Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI.
      Title: Inhibition of Microrna-766-5p Attenuates the Development of Cervical Cancer Through Regulating SCAI.
    5. Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI.
      Title: Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI.
    6. miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI.
      Title: miR-371b-5p promotes cell proliferation, migration and invasion in non-small cell lung cancer via SCAI.
    7. MicroRNA-625-3p was highly expressed in oral squamous cell carcinoma (OSCC) tissues. OSCC patients with T3+T4 stage had higher expression of microRNA-625-3p than those with T1+T2 stage. SCAI was identified as a target gene of microRNA-625-3p. ROC curve showed that microRNA-625-3p and SCAI exert certain values in diagnosing OSCC. MicroRNA-625-3p promoted migration of OSCC cells, which was reversed by SCAI knockdown.
      Title: MicroRNA-625-3p promotes cell migration of oral squamous cell carcinoma by regulating SCAI expression.
    8. This study provides evidence that CAF exosomal miR-1228 is able to promote osteosarcoma invasion and migration by targeting SCAI.
      Title: Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell Migration and Invasion of Osteosarcoma by Directly Targeting SCAI.
    9. SCAI binds to miR-1270 which inversely regulates SCAI gene expression in papillary thyroid cancer cells.
      Title: MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI.
    10. High SCAI expression is associated with gastric, prostate, and colorectal cancer.
      Title: Alterations in SCAI Expression during Cell Plasticity, Fibrosis and Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11758, FLJ36664, MGC120525, MGC120526, MGC120528

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein SCAI
    Names
    suppressor of cancer cell invasion protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016620.1 RefSeqGene

      Range
      5032..205952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144877.3 → NP_001138349.1  protein SCAI isoform 2

      See identical proteins and their annotated locations for NP_001138349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL451125, BC104031, BM873972, DB048788
      Consensus CDS
      CCDS48017.1
      UniProtKB/Swiss-Prot
      Q3SXZ1, Q3SXZ2, Q5T163, Q8N1I4, Q8N9R8
      Related
      ENSP00000336756.6, ENST00000336505.11
      Conserved Domains (1) summary
      pfam12070
      Location:64 → 557
      SCAI; Protein SCAI

    2. NM_173690.5 → NP_775961.2  protein SCAI isoform 1

      See identical proteins and their annotated locations for NP_775961.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL451125, BC104030, BM873972, DB048788
      Consensus CDS
      CCDS43877.1
      UniProtKB/Swiss-Prot
      Q8N9R8
      Related
      ENSP00000362650.4, ENST00000373549.8
      Conserved Domains (1) summary
      pfam12070
      Location:87 → 580
      SCAI; Protein SCAI

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      124942608..125143528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007061282.1 RNA Sequence

    2. XR_007061281.1 RNA Sequence

    3. XR_007061283.1 RNA Sequence

    4. XR_929768.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137140969..137341870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487985.1 RNA Sequence

    2. XR_008487984.1 RNA Sequence

    3. XR_008487987.1 RNA Sequence

    4. XR_008487986.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9R8.2 GenPept UniProtKB/Swiss-Prot:Q8N9R8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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