U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CAPRIN1 cell cycle associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 4076, updated on 3-Dec-2024

    Summary

    Official Symbol
    CAPRIN1provided by HGNC
    Official Full Name
    cell cycle associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:6743
    See related
    Ensembl:ENSG00000135387 MIM:601178; AllianceGenome:HGNC:6743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M11S1; GPIAP1; RNG105; CONDCAC; GPIP137; GRIP137; NEDLAAD; p137GPI
    Summary
    Enables several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in non-membrane-bounded organelle assembly; positive regulation of stress granule assembly; and regulation of gene expression. Located in cell leading edge and cytosol. Is active in intracellular non-membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAPRIN1 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (34051731..34102610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (34188759..34239614)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34073278..34124157)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4587 Neighboring gene uncharacterized LOC105376621 Neighboring gene uncharacterized LOC124902659 Neighboring gene Sharpr-MPRA regulatory region 4704 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1732 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1733 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1734 Neighboring gene VISTA enhancer hs1858 Neighboring gene Sharpr-MPRA regulatory region 12713 Neighboring gene Sharpr-MPRA regulatory region 9356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34011296-34011867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34018010-34018510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34018511-34019011 Neighboring gene uncharacterized LOC101929918 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34072933-34073132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4591 Neighboring gene uncharacterized LOC124902660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34171467-34171996 Neighboring gene N-acetyltransferase 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34177103-34177604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181310-34181810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34181811-34182311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34195130-34196052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34196053-34196973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34204513-34205014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34205015-34205514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34208067-34208830 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:34213997-34214182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34214651-34215536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34215704-34216532 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34226078-34226684 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:34255548-34256072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34260669-34261168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34261893-34262392 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:34263557-34264756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:34264949-34265620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4600 Neighboring gene Sharpr-MPRA regulatory region 14004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306064-34306564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34306565-34307065 Neighboring gene MPRA-validated peak1251 silencer Neighboring gene MMADHC pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline
    MedGen: C5882726 OMIM: 620636 GeneReviews: Not available
    not available
    Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder
    MedGen: C5935603 OMIM: 620782 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2024-07-24)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2024-07-24)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cell cycle associated protein 1 (CAPRIN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, cell cycle associated protein 1 (CAPRIN1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CAPRIN1 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular function activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membraneless organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    caprin-1
    Names
    GPI-anchored membrane protein 1
    GPI-anchored protein p137
    GPI-p137
    RNA granule protein 105
    activation/proliferation-associated protein 1
    caprin 1
    cytoplasmic activation- and proliferation-associated protein 1
    cytoplasmic activation/proliferation-associated protein-1
    membrane component chromosome 11 surface marker 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005898.5NP_005889.3  caprin-1 isoform 1

      See identical proteins and their annotated locations for NP_005889.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090469
      Consensus CDS
      CCDS31453.1
      UniProtKB/Swiss-Prot
      A6NMY7, D3DR06, Q14444, Q15074, Q6IMN4, Q6IMN7, Q9BV09
      UniProtKB/TrEMBL
      B3KXU8
      Related
      ENSP00000340329.4, ENST00000341394.9
      Conserved Domains (3) summary
      COG0419
      Location:52198
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam12287
      Location:359681
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:132247
      Caprin-1_dimer; Caprin-1 dimerization domain
    2. NM_203364.3NP_976240.1  caprin-1 isoform 2

      See identical proteins and their annotated locations for NP_976240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC090469
      Consensus CDS
      CCDS31454.1
      UniProtKB/TrEMBL
      B3KXU8
      Related
      ENSP00000374296.3, ENST00000389645.7
      Conserved Domains (3) summary
      COG0419
      Location:52198
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam12287
      Location:359685
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam18293
      Location:132247
      Caprin-1_dimer; Caprin-1 dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      34051731..34102610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426960.1XP_047282916.1  caprin-1 isoform X1

    2. XM_047426959.1XP_047282915.1  caprin-1 isoform X2

      UniProtKB/Swiss-Prot
      A6NMY7, D3DR06, Q14444, Q15074, Q6IMN4, Q6IMN7, Q9BV09
      UniProtKB/TrEMBL
      B3KXU8
      Related
      ENSP00000434150.1, ENST00000532820.5
    3. XM_047426961.1XP_047282917.1  caprin-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      34188759..34239614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368807.1XP_054224782.1  caprin-1 isoform X1