Myod1 myogenic differentiation 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myod1provided by MGI
Official Full Name: myogenic differentiation 1provided by MGI
Primary source: MGI:MGI:97275
See related: Ensembl:ENSMUSG00000009471 AllianceGenome:MGI:97275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MYF3; MyoD; Myod-1; bHLHc1
Summary: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and DNA-binding transcription factor binding activity. Contributes to DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of snRNA transcription by RNA polymerase II; and skeletal muscle cell differentiation. Acts upstream of or within several processes, including myotube differentiation; regulation of RNA metabolic process; and skeletal muscle fiber adaptation. Located in euchromatin; myofibril; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; limb; limb bud; and skeletal musculature. Human ortholog(s) of this gene implicated in congenital myopathy 17. Orthologous to human MYOD1 (myogenic differentiation 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 31.5), CNS E11.5 (RPKM 3.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 30.03 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46025898..46028516)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (46376474..46379092)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nonsense-mediated mRNA decay suppresses injury-induced muscle regeneration via inhibiting MyoD transcriptional activity.
Title: Nonsense-mediated mRNA decay suppresses injury-induced muscle regeneration via inhibiting MyoD transcriptional activity.
Foxo3 Knockdown Mediates Decline of Myod1 and Myog Reducing Myoblast Conversion to Myotubes.
Title: Foxo3 Knockdown Mediates Decline of Myod1 and Myog Reducing Myoblast Conversion to Myotubes.
IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
Title: IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
Cardiolipin metabolism regulates expression of muscle transcription factor MyoD1 and muscle development.
Title: Cardiolipin metabolism regulates expression of muscle transcription factor MyoD1 and muscle development.
Palmitic Acid Inhibits Myogenic Activity and Expression of Myosin Heavy Chain MHC IIb in Muscle Cells through Phosphorylation-Dependent MyoD Inactivation.
Title: Palmitic Acid Inhibits Myogenic Activity and Expression of Myosin Heavy Chain MHC IIb in Muscle Cells through Phosphorylation-Dependent MyoD Inactivation.
MyoD is a 3D genome structure organizer for muscle cell identity.
Title: MyoD is a 3D genome structure organizer for muscle cell identity.
Development of Nystagmus With the Absence of MYOD Expression in the Extraocular Muscles.
Title: Development of Nystagmus With the Absence of MYOD Expression in the Extraocular Muscles.
Enhanced growth and myogenic differentiation of spheroid-derived C2C12 cells.
Title: Enhanced growth and myogenic differentiation of spheroid-derived C2C12 cells.
Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
Title: Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
Inhibition of MEF2c and MyoD expression in the SM of lipin1(Myf5cKO) mice.
Title: Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.

Submit: New GeneRIF Correction See all GeneRIFs (195)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myod1 (e-PCR), detects polymorphism
- UniSTS:158746

NoName (e-PCR)
- UniSTS:548384

PMC151607P3 (e-PCR)
- UniSTS:271153

NoName (e-PCR)
- UniSTS:484948

PMC162217P1 (e-PCR)
- UniSTS:271461

Myod1 (e-PCR), detects polymorphism
- UniSTS:143976

Myod1 (e-PCR), detects polymorphism
- UniSTS:143977

Myod1 (e-PCR), detects polymorphism
- UniSTS:143978

PMC133998P3 (e-PCR)
- UniSTS:270708

AI503393 (e-PCR)
- UniSTS:179577

PMC86965P5 (e-PCR)
- UniSTS:273571

Myod1 (e-PCR), detects polymorphism
- UniSTS:545964

Myod1 (e-PCR), detects polymorphism
- UniSTS:265670

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IC Inferred by Curator more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to oxygen levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within muscle organ development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myoblast fate determination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myotube cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chromatin binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of snRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber adaptation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed
involved_in skeletal muscle tissue regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myoblast determination protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010866.2 → NP_034996.2 myoblast determination protein 1

See identical proteins and their annotated locations for NP_034996.2

Status: VALIDATED

Source sequence(s)

AK076157

Consensus CDS

CCDS21277.1

UniProtKB/Swiss-Prot

P10085, Q8C6B1

Related

ENSMUSP00000072330.2, ENSMUST00000072514.3

Conserved Domains (3) summary

smart00520
Location:19 → 114

BASIC; Basic domain in HLH proteins of MYOD family

pfam00010
Location:110 → 161

HLH; Helix-loop-helix DNA-binding domain

pfam12232
Location:190 → 258

Myf5; Myogenic determination factor 5