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    DDX24 DEAD-box helicase 24 [ Homo sapiens (human) ]

    Gene ID: 57062, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DDX24provided by HGNC
    Official Full Name
    DEAD-box helicase 24provided by HGNC
    Primary source
    HGNC:HGNC:13266
    See related
    Ensembl:ENSG00000089737 MIM:606181; AllianceGenome:HGNC:13266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 90.5), adrenal (RPKM 75.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DDX24 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (94048287..94081202, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (88275602..88308519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94514633..94547548, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984663 Neighboring gene uncharacterized LOC124903368 Neighboring gene coiled-coil domain containing 197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:94482885-94483384 Neighboring gene Sharpr-MPRA regulatory region 4126 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:94518750-94519679 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:94526511-94527710 Neighboring gene interferon alpha inducible protein 27 like 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:94576419-94577618 Neighboring gene interferon alpha inducible protein 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera. Pang P, et al. Hepatology, 2019 Feb. PMID 30063812, Free PMC Article
    2. DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App(N-LF) Mice and Influences Presymptomatic Pathology. Axenhus M, et al. Int J Mol Sci, 2024 Mar 23. PMID 38612434, Free PMC Article
    3. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. Zhao Y, et al. Genomics, 2000 Aug 1. PMID 10936056
    4. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. Ma J, et al. Virology, 2008 May 25. PMID 18289627
    5. RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression. Liu T, et al. Cancer Res, 2022 Sep 2. PMID 35763670

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App[N-LF] Mice and Influences Presymptomatic Pathology.
      Title: DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App(N-LF) Mice and Influences Presymptomatic Pathology.
    2. DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer.
      Title: DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer.
    3. DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations.
      Title: DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations.
    4. DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.
      Title: DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.
    5. DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs.
      Title: DExD/H Box Helicases DDX24 and DDX49 Inhibit Reactivation of Kaposi's Sarcoma Associated Herpesvirus by Interacting with Viral mRNAs.
    6. RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.
      Title: RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.
    7. Identification of Prognostic RBPs in Osteosarcoma.
      Title: Identification of Prognostic RBPs in Osteosarcoma.
    8. p.Glu271Lys associated with malformations of major vessels
      Title: DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera.
    9. DDX24 is a negative regulator of p53 transcriptional activity.DDX24 inhibits p300 mediated acetylation of p53.
      Title: Negative regulation of the p300-p53 interplay by DDX24.
    10. depletion of DDX24 in cells impaired pre-rRNA processing and resulted both in abrogation of MDM2 function and in consequent p53 stabilization
      Title: MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (DDX24), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev Decreased viral RNA packaging as a result of DDX24-knockdown is observed only in the context of Rev/RRE-dependent but not CTE (constitutive transport element)-mediated nuclear export of viral RNA PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    DEAD (Asp-Glu-Ala-Asp) box helicase 24
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    DEAD box protein 24
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24
    S. cerevisiae CHL1-like helicase
    NP_065147.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020414.4 → NP_065147.1  ATP-dependent RNA helicase DDX24

      See identical proteins and their annotated locations for NP_065147.1

      Status: REVIEWED

      Source sequence(s)
      AL079302
      Consensus CDS
      CCDS9918.1
      UniProtKB/Swiss-Prot
      E7EMJ4, Q4V9L5, Q9GZR7
      UniProtKB/TrEMBL
      G3V529
      Related
      ENSP00000481495.1, ENST00000621632.5
      Conserved Domains (3) summary
      COG0513
      Location:191 → 783
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:573 → 681
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:194 → 511
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      94048287..94081202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1162849..1195764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      88275602..88308519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZR7.1 GenPept UniProtKB/Swiss-Prot:Q9GZR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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