CCR7 C-C motif chemokine receptor 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCR7provided by HGNC
Official Full Name: C-C motif chemokine receptor 7provided by HGNC
Primary source: HGNC:HGNC:1608
See related: Ensembl:ENSG00000126353 MIM:600242; AllianceGenome:HGNC:1608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7
Summary: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression: Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (40553769..40565472, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (41418143..41429846, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (38710021..38721724, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic Leukemia Invasion of the Central Nervous System via beta2-Integrins.
Title: C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic Leukemia Invasion of the Central Nervous System via β2-Integrins.
CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth.
Title: CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck squamous cell carcinoma growth.
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma.
Title: CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma.
CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer.
Title: CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer.
Effects of chemokine receptor CCR7 in the pathophysiology and clinical features of the immuno-inflammatory response in primary pterygium.
Title: Effects of chemokine receptor CCR7 in the pathophysiology and clinical features of the immuno-inflammatory response in primary pterygium.
Heparin Specifically Interacts with Basic BBXB Motifs of the Chemokine CCL21 to Define CCR7 Signaling.
Title: Heparin Specifically Interacts with Basic BBXB Motifs of the Chemokine CCL21 to Define CCR7 Signaling.
CCR7 alterations associated with inferior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment.
Title: CCR7 alterations associated with inferior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment.
Effects of let-7a microRNA and C-C chemokine receptor type 7 expression on cellular function and prognosis in esophageal squamous cell carcinoma.
Title: Effects of let-7a microRNA and C-C chemokine receptor type 7 expression on cellular function and prognosis in esophageal squamous cell carcinoma.
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance.
Title: Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and Cardiac Rhythm Maintenance.
EXPRESSION OF CHEMOKINE (C-C MOTIF) RECEPTOR 7 IN PROSTATE CANCER TISSUE OF YOUNG PATIENTS AND IN METASTATIC CANCER CELLS.
Title: EXPRESSION OF CHEMOKINE (C-C MOTIF) RECEPTOR 7 IN PROSTATE CANCER TISSUE OF YOUNG PATIENTS AND IN METASTATIC CANCER CELLS.

Submit: New GeneRIF Correction See all GeneRIFs (254)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CCR7	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the level of CXCR4/CCR7 hetero-oligomerization in CD4+ T cells	PubMed
	env	HIV-1 gp120 interacts with CD4 and CXCR4 to enhance CCR7-dependent human CD4+ T cell migration	PubMed
	env	Stimulated HIV-1 infected CD4+ cells induce plasmacytoid dendritic cell (PDC) activation and maturation in a manner that is inhibited by antibodies to HIV-1 gp120; markers for PDC migration (CCR7) are enhanced during this process	PubMed
	env	Inhibition of CpG-B-induced maturation of plasmacytoid dendritic cells by HIV-1 gp120 results in downregulation of CD40, CD83, CCR7, and HLA-DR expression	PubMed
	env	HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR	PubMed
Nef	nef	HIV-1 Nef induces variable levels of CCR7 downregulation in different cell types	PubMed
	nef	HIV-1 Nef-pulsed mDCs downregulate HLA-DR expression and upregulate CD25 and CCR7 expression in NK cells	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of chemokine (C-C motif) receptor 7 (CCR7) in Vif-expression T cells	PubMed
Vpu	vpu	HIV-1 (NL4-3) Vpu downregulates CCR7 expression on cells (primary CD4+ T cells)	PubMed
	vpu	HIV-1 (NL4-3) Vpu downregulates CCR7 via a cullin-RING E3 ubiquitin ligase complex-independent mechanism	PubMed
	vpu	HIV-1 Vpu is necessary and sufficient for cell-surface CCR7 downregulation but not degradation of CCR7, and the trans-membrane domain of Vpu is required for downregulation of CCR7 in CD4+ T cells	PubMed
	vpu	Vpu-mediated downregulation of CCR7 upon viral infection results in an impaired ability of infected primary CD4+ T cells to respond to CCL19	PubMed
	vpu	HIV-1 Vpu specifically co-localizes with CCR7 within the trans-Golgi network cellular compartment	PubMed
matrix	gag	Treatment of plasmacytoid dendritic cells (pDCs) with HIV-1 MA upregulates the expression of CCR7. Coculture with MA and CCL19 induces a dose-dependent migration of pDCs	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CCR7_s4 (e-PCR)
- UniSTS:510343

PMC135988P9 (e-PCR)
- UniSTS:270795

RH69039 (e-PCR)
- UniSTS:52942

PMC321570P11 (e-PCR)
- UniSTS:273114

D17S2011 (e-PCR)
- UniSTS:64735

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables C-C chemokine receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables C-C motif chemokine 19 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C motif chemokine 19 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables C-C motif chemokine 21 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables chemokine (C-C motif) ligand 19 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 19 binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemokine (C-C motif) ligand 21 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 21 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine (C-C motif) ligand 19 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemokine (C-C motif) ligand 21 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in dendritic cell chemotaxis	IC Inferred by Curator more info	PubMed
involved_in establishment of T cell polarity	IC Inferred by Curator more info	PubMed
involved_in homeostasis of number of cells	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in lymphocyte migration into lymph node	TAS Traceable Author Statement more info	PubMed
involved_in mature conventional dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid dendritic cell chemotaxis	IC Inferred by Curator more info	PubMed
involved_in myeloid dendritic cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendritic cell apoptotic process	IC Inferred by Curator more info	PubMed
acts_upstream_of negative regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IC Inferred by Curator more info	PubMed
involved_in positive regulation of JNK cascade	IC Inferred by Curator more info	PubMed
involved_in positive regulation of T cell costimulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IC Inferred by Curator more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IC Inferred by Curator more info	PubMed
involved_in positive regulation of cell adhesion	IC Inferred by Curator more info	PubMed
involved_in positive regulation of cell motility	IC Inferred by Curator more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IC Inferred by Curator more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic cell antigen processing and presentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	IC Inferred by Curator more info	PubMed
involved_in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of humoral immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hypersensitivity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immunological synapse formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IC Inferred by Curator more info	PubMed
involved_in positive regulation of protein kinase activity	IC Inferred by Curator more info	PubMed
involved_in positive regulation of pseudopodium assembly	IC Inferred by Curator more info	PubMed
involved_in regulation of dendritic cell dendrite assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IC Inferred by Curator more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to nitric oxide	IC Inferred by Curator more info	PubMed
involved_in response to prostaglandin E	IC Inferred by Curator more info	PubMed
involved_in ruffle organization	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: C-C chemokine receptor type 7

Names: Bukitt's lymphoma receptor 2; CC chemokine receptor 7; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; MIP-3 beta receptor; chemokine (C-C motif) receptor 7; lymphocyte-specific G protein-coupled peptide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301714.2 → NP_001288643.1 C-C chemokine receptor type 7 isoform b

See identical proteins and their annotated locations for NP_001288643.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

BC035343, BI910219, DA814913

UniProtKB/TrEMBL

B2R6V6

Conserved Domains (1) summary

pfam00001
Location:12 → 263

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001301716.2 → NP_001288645.1 C-C chemokine receptor type 7 isoform c precursor

See identical proteins and their annotated locations for NP_001288645.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.

Source sequence(s)

AK310277, BC035343

Consensus CDS

CCDS77026.1

UniProtKB/TrEMBL

B2R6V6, J3KSS9

Related

ENSP00000462631.1, ENST00000579344.2

Conserved Domains (1) summary

cd15175
Location:53 → 331

7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001301717.2 → NP_001288646.1 C-C chemokine receptor type 7 isoform c precursor

See identical proteins and their annotated locations for NP_001288646.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.

Source sequence(s)

AK310277, BC035343, HY017993

Consensus CDS

CCDS77026.1

UniProtKB/TrEMBL

B2R6V6, J3KSS9

Conserved Domains (1) summary

cd15175
Location:53 → 331

7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001301718.2 → NP_001288647.1 C-C chemokine receptor type 7 isoform c precursor

See identical proteins and their annotated locations for NP_001288647.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.

Source sequence(s)

BC035343, HY021417

Consensus CDS

CCDS77026.1

UniProtKB/TrEMBL

B2R6V6, J3KSS9

Conserved Domains (1) summary

cd15175
Location:53 → 331

7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001838.4 → NP_001829.1 C-C chemokine receptor type 7 isoform a precursor

See identical proteins and their annotated locations for NP_001829.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

BC035343, L31581

Consensus CDS

CCDS11369.1

UniProtKB/Swiss-Prot

P32248

UniProtKB/TrEMBL

A0N0Q0, B2R6V6

Related

ENSP00000246657.2, ENST00000246657.2

Conserved Domains (1) summary

cd15175
Location:59 → 337

7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors