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    FFAR4 free fatty acid receptor 4 [ Homo sapiens (human) ]

    Gene ID: 338557, updated on 10-Dec-2024

    Summary

    Official Symbol
    FFAR4provided by HGNC
    Official Full Name
    free fatty acid receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:19061
    See related
    Ensembl:ENSG00000186188 MIM:609044; AllianceGenome:HGNC:19061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GT01; PGR4; OB10Q; BMIQ10; GPR120; GPR129; O3FAR1
    Summary
    This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
    Expression
    Biased expression in colon (RPKM 6.8), fat (RPKM 2.6) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FFAR4 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93566665..93590072)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94446619..94470024)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95326422..95349829)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3496 Neighboring gene centrosomal protein 55 Neighboring gene RNA, 5S ribosomal pseudogene 323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:95315968-95316468 Neighboring gene uncharacterized LOC105378436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:95325824-95326662 Neighboring gene uncharacterized LOC124902485 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:95341272-95341477 Neighboring gene retinol binding protein 4 Neighboring gene phosphodiesterase 6C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Body mass index quantitative trait locus 10
    MedGen: C2675659 OMIM: 607514 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of circulating retinol levels.
    EBI GWAS Catalog

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC119984, DKFZp686F0824

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables arrestin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in detection of chemical stimulus involved in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ghrelin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of somatostatin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glucagon secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of D-glucose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in white fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    free fatty acid receptor 4
    Names
    G-protein coupled receptor 120
    G-protein coupled receptor 129
    G-protein coupled receptor GT01
    G-protein coupled receptor PGR4
    Obesity, susceptibility to, on chromosome 10q
    omega-3 fatty acid receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032670.1 RefSeqGene

      Range
      5001..28408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195755.2NP_001182684.1  free fatty acid receptor 4 isoform GPR120-S

      See identical proteins and their annotated locations for NP_001182684.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an in-frame coding exon compared to variant 1, resulting in a shorter isoform (GPR120-S) lacking a 16 aa protein segment compared to isoform GPR120-L.
      Source sequence(s)
      AI469384, AI732606, AK301525, AL356214, BC101175, BM757151, DA986310
      Consensus CDS
      CCDS55720.1
      UniProtKB/Swiss-Prot
      Q495H1, Q5NUL3, Q5VY25, Q5VY26, Q7Z605, Q86SM7
      UniProtKB/TrEMBL
      B4DWG6
      Related
      ENSP00000360536.5, ENST00000371481.9
      Conserved Domains (1) summary
      cd00637
      Location:43321
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
    2. NM_181745.4NP_859529.2  free fatty acid receptor 4 isoform GPR120-L

      See identical proteins and their annotated locations for NP_859529.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (GPR120-L).
      Source sequence(s)
      AI469384, AI732606, AK301525, AL356214, AY288417, BC101175, BM757151, DA986310
      Consensus CDS
      CCDS31248.1
      UniProtKB/TrEMBL
      B4DWG6
      Related
      ENSP00000360538.4, ENST00000371483.8
      Conserved Domains (1) summary
      pfam00001
      Location:73337
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      93566665..93590072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539746.4XP_011538048.1  free fatty acid receptor 4 isoform X1

      UniProtKB/TrEMBL
      S4R3L2
      Conserved Domains (1) summary
      pfam00001
      Location:73233
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      94446619..94470024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365713.1XP_054221688.1  free fatty acid receptor 4 isoform X1

      UniProtKB/TrEMBL
      S4R3L2