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    MT4 metallothionein 4 [ Homo sapiens (human) ]

    Gene ID: 84560, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MT4provided by HGNC
    Official Full Name
    metallothionein 4provided by HGNC
    Primary source
    HGNC:HGNC:18705
    See related
    Ensembl:ENSG00000102891 MIM:606206; AllianceGenome:HGNC:18705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT-4; MTIV; MT-IV
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including cellular response to zinc ion; detoxification of copper ion; and intracellular zinc ion homeostasis. Predicted to act upstream of or within intracellular monoatomic cation homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See MT4 in Genome Data Viewer
    Location:
    16q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56565073..56568957)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62359992..62363895)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56598985..56602869)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 1 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene Sharpr-MPRA regulatory region 6357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10851 Neighboring gene uncharacterized LOC105371283 Neighboring gene U7 small nuclear RNA Neighboring gene metallothionein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers. Chen HI, et al. Biol Trace Elem Res, 2010 Oct. PMID 19921116
    2. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Quaife CJ, et al. Biochemistry, 1994 Jun 14. PMID 8003488
    3. Genetic background of lead and mercury metabolism in a group of medical students in Austria. Gundacker C, et al. Environ Res, 2009 Aug. PMID 19515364
    4. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Izmailova E, et al. Nat Med, 2003 Feb. PMID 12539042
    5. Human gingiva transcriptome during wound healing. Wang Y, et al. J Clin Periodontol, 2017 Apr. PMID 28005267

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MT4 expression is significantly downregulated in human masticatory mucosa during wound healing
      Title: Human gingiva transcriptome during wound healing.
    2. The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers
      Title: The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: The association of metallothionein-4 gene polymorphism and renal function in long-term lead-exposed workers.
    5. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
      Title: Genetic background of lead and mercury metabolism in a group of medical students in Austria.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detoxification of copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metallothionein-4
    Names
    metallothionein-IV

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032935.3 → NP_116324.2  metallothionein-4

      Status: VALIDATED

      Source sequence(s)
      AC026461
      Consensus CDS
      CCDS42165.1
      UniProtKB/Swiss-Prot
      P47944, Q14DA1
      Related
      ENSP00000219162.3, ENST00000219162.4
      Conserved Domains (1) summary
      pfam00131
      Location:5 → 61
      Metallothio; Metallothionein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      56565073..56568957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62359992..62363895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47944.2 GenPept UniProtKB/Swiss-Prot:P47944

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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