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    AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 [ Homo sapiens (human) ]

    Gene ID: 55326, updated on 2-Nov-2024

    Summary

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    Official Symbol
    AGPAT5provided by HGNC
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 5provided by HGNC
    Primary source
    HGNC:HGNC:20886
    See related
    Ensembl:ENSG00000155189 MIM:614796; AllianceGenome:HGNC:20886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPAATE; LPLAT5; 1AGPAT5
    Summary
    This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]
    Expression
    Broad expression in testis (RPKM 16.0), brain (RPKM 13.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AGPAT5 in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (6708642..6761503)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (6464039..6516588)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6566163..6619024)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microcephalin 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:6385720-6386919 Neighboring gene angiopoietin 2 Neighboring gene Sharpr-MPRA regulatory region 12768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6419583-6420108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6420109-6420635 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6434138-6434684 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:6436241-6436413 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_103492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:6446215-6446714 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6450530-6451446 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:6451447-6452362 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:6456108-6457307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6459927-6460426 Neighboring gene NANOG hESC enhancer GRCh37_chr8:6473596-6474097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6481178-6481678 Neighboring gene MCPH1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:6505663-6506862 Neighboring gene microRNA 8055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18884 Neighboring gene protein tyrosine phosphatase non-receptor type 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26956 Neighboring gene Sharpr-MPRA regulatory region 12268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6611625-6612126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6612127-6612626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26958 Neighboring gene microRNA 4659b Neighboring gene microRNA 4659a Neighboring gene ReSE screen-validated silencer GRCh37_chr8:6624955-6625205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6631643-6632143 Neighboring gene uncharacterized LOC124901872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18887 Neighboring gene uncharacterized LOC107986909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6662895-6663395

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The structure and functions of human lysophosphatidic acid acyltransferases. Leung DW. Front Biosci, 2001 Aug 1. PMID 11487472
    2. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. Prasad SS, et al. J Lipid Res, 2011 Mar. PMID 21173190, Free PMC Article
    3. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. Agarwal AK, et al. Arch Biochem Biophys, 2006 May 15. PMID 16620771
    4. Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart. Lu B, et al. Biochem J, 2005 Jan 15. PMID 15367102, Free PMC Article
    5. Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Zang W, et al. Proc Natl Acad Sci U S A, 2019 Dec 17. PMID 31796584, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. enzymatic properties, tissue distribution, and subcellular localization of human AGPAT3 and AGPAT5
      Title: Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. This publication describes the molecular cloning, tissue distribution, and enzyme characterization of the mouse homolog, mAGPAT5.
      Title: Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
    Names
    1-AGP acyltransferase 5
    1-AGPAT 5
    1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
    lysophosphatidic acid acyltransferase epsilon
    lysophospholipid acyltransferase 5
    testicular tissue protein Li 144
    NP_060831.2
    XP_047277894.1
    XP_047277895.1
    XP_047277896.1
    XP_054188223.1
    XP_054188224.1
    XP_054188225.1
    XP_054216743.1
    XP_054216744.1
    XP_054216745.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018361.5 → NP_060831.2  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

      See identical proteins and their annotated locations for NP_060831.2

      Status: REVIEWED

      Source sequence(s)
      AF287957
      Consensus CDS
      CCDS34796.1
      UniProtKB/Swiss-Prot
      Q8IZ47, Q9BQG4, Q9NUQ2
      UniProtKB/TrEMBL
      A0A024R640, Q6NUM7
      Related
      ENSP00000285518.6, ENST00000285518.11
      Conserved Domains (3) summary
      cd07990
      Location:63 → 263
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      COG0204
      Location:34 → 281
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam16076
      Location:258 → 318
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      6708642..6761503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421939.1 → XP_047277895.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    2. XM_047421938.1 → XP_047277894.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    3. XM_047421940.1 → XP_047277896.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      103912..156773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332249.1 → XP_054188224.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    2. XM_054332248.1 → XP_054188223.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    3. XM_054332250.1 → XP_054188225.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      6464039..6516588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360769.1 → XP_054216744.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    2. XM_054360768.1 → XP_054216743.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1

    3. XM_054360770.1 → XP_054216745.1  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NUQ2.3 GenPept UniProtKB/Swiss-Prot:Q9NUQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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