PTGR3 prostaglandin reductase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTGR3provided by HGNC
Official Full Name: prostaglandin reductase 3provided by HGNC
Primary source: HGNC:HGNC:28697
See related: Ensembl:ENSG00000180011 MIM:620604; AllianceGenome:HGNC:28697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRG-3; ZADH2; PTGR-3
Summary: Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta (RPKM 7.9), thyroid (RPKM 6.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 18q22.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (75195108..75209139, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (75424502..75438532, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (72907063..72921094, complement)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
Title: [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
Title: Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
In patients with late-onset Alzheimer disease, a number of differentially methylated postitions were hypomethylated in ZADH2 compared with controls.
Title: DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47795 (e-PCR)
- UniSTS:81982

WI-22260 (e-PCR)
- UniSTS:31571

RH103890 (e-PCR)
- UniSTS:98215

RH78532 (e-PCR)
- UniSTS:15272

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular_function	ND No biological Data available more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	HTP more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostaglandin reductase 3

Names: zinc binding alcohol dehydrogenase domain containing 2; zinc-binding alcohol dehydrogenase domain-containing protein 2

NP_001293022.1

EC 1.3.1.48

NP_787103.1

EC 1.3.1.48

XP_024306934.1

EC 1.3.1.48

XP_054174512.1

EC 1.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306093.1 → NP_001293022.1 prostaglandin reductase 3 isoform 2

See identical proteins and their annotated locations for NP_001293022.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC025105, AK302801, BU682476, BX647730

Consensus CDS

CCDS77198.1

UniProtKB/Swiss-Prot

Q8N4Q0

Related

ENSP00000440111.2, ENST00000537114.2

Conserved Domains (1) summary

cl16912
Location:1 → 245

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
NM_175907.6 → NP_787103.1 prostaglandin reductase 3 isoform 1

See identical proteins and their annotated locations for NP_787103.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC025105, BC018081, BU682476

Consensus CDS

CCDS12008.1

UniProtKB/Swiss-Prot

A8KA15, B4DZ91, Q8N4Q0

UniProtKB/TrEMBL

Q4G1C4

Related

ENSP00000323678.3, ENST00000322342.4

Conserved Domains (1) summary

cd08250
Location:32 → 368

Mgc45594_like; Mgc45594 gene product and other MDR family members

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000018.10 Reference GRCh38.p14 Primary Assembly

Range

75195108..75209139 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024451166.2 → XP_024306934.1 prostaglandin reductase 3 isoform X1

Conserved Domains (1) summary

cl16912
Location:1 → 245

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family