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    MSRB3-AS1 MSRB3 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100507065, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MSRB3-AS1provided by HGNC
    Official Full Name
    MSRB3 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:53386
    See related
    AllianceGenome:HGNC:53386
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in endometrium (RPKM 59.1), esophagus (RPKM 47.6) and 22 other tissues See more
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    Genomic context

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    See MSRB3-AS1 in Genome Data Viewer
    Location:
    12q14.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (65466817..65642372, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (65446265..65621862, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (65860597..66036152, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase B3 Neighboring gene uncharacterized LOC124902954 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:65824313-65825512 Neighboring gene keratin 18 pseudogene 60 Neighboring gene uncharacterized LOC105369809 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:65930061-65931260 Neighboring gene uncharacterized LOC105369187 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:65950046-65951245 Neighboring gene uncharacterized LOC105369808 Neighboring gene uncharacterized LOC105369806 Neighboring gene long intergenic non-protein coding RNA 2454 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:66050206-66051405 Neighboring gene PEST containing nuclear protein pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9176 Neighboring gene MPRA-validated peak1767 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:66132196-66132696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:66135292-66135792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:66135793-66136293 Neighboring gene MPRA-validated peak1768 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:66155026-66155586 Neighboring gene Sharpr-MPRA regulatory region 15140 Neighboring gene NANOG hESC enhancer GRCh37_chr12:66172695-66173196 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:66175547-66176083 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:66192736-66193237 Neighboring gene ribosomal protein SA pseudogene 52 Neighboring gene Sharpr-MPRA regulatory region 869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:66219383-66219990 Neighboring gene high mobility group AT-hook 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA ENST00000539653 acts as an oncogenic factor via MAPK signalling in papillary thyroid cancer. Song B, et al. BMC Cancer, 2019 Apr 2. PMID 30940124, Free PMC Article
    2. The Long Non-Coding RNA RP5-1024C24.1 and Its Associated-Gene MPPED2 Are Down-Regulated in Human Thyroid Neoplasias and Act as Tumour Suppressors. Sepe R, et al. Cancers (Basel), 2018 May 18. PMID 29783666, Free PMC Article
    3. Creation of genome-wide protein expression libraries using random activation of gene expression. Harrington JJ, et al. Nat Biotechnol, 2001 May. PMID 11329013

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Other Names

    • RP11-230G5.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_120431.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript.
      Source sequence(s)
      AC025419, AC090023

    2. NR_120432.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 3' end and contains two alternate internal exons, resulting in a longer transcript, compared to variant 1.
      Source sequence(s)
      AC025419, AC090023, BE895205, BG186681, BU155316

    3. NR_120433.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs at the 3' end and contains two alternate internal exons, resulting in a longer transcript, compared to variant 1.
      Source sequence(s)
      AC025419, AC090023

    4. NR_120434.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs at the 3' end, contains two alternate internal exons, and uses an alternate splice site, resulting in a longer transcript, compared to variant 1.
      Source sequence(s)
      AC090023, BM550610, BU155316, CA416293

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      65466817..65642372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      65446265..65621862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials