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    SHISAL1 shisa like 1 [ Homo sapiens (human) ]

    Gene ID: 85352, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SHISAL1provided by HGNC
    Official Full Name
    shisa like 1provided by HGNC
    Primary source
    HGNC:HGNC:29335
    See related
    Ensembl:ENSG00000138944 MIM:620220; AllianceGenome:HGNC:29335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1644
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in endometrium (RPKM 16.5), brain (RPKM 11.5) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SHISAL1 in Genome Data Viewer
    Location:
    22q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (44243665..44331714, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (44727485..44815559, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (44639545..44708831, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene parvin beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44550653-44551476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44551477-44552300 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44553755-44554288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44554289-44554822 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:44556425-44556958 Neighboring gene tRNA-SeC (anticodon TCA) 2-1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44563307-44564086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44565977-44566498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44570650-44571382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44576792-44577522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44577523-44578252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44578253-44578982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44588052-44588637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44588638-44589222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44596327-44597136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44597948-44598757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44600519-44601019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44600018-44600518 Neighboring gene parvin gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44616903-44617455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44658947-44659462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44676595-44677095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44678007-44678506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44685764-44686707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44688595-44689536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44694997-44695529 Neighboring gene uncharacterized LOC101927499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44713193-44713692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44712691-44713192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44733447-44734210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44734211-44734974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44748529-44749458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44765925-44766426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44787184-44788062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44788063-44788941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44791267-44791872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44839807-44840536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44840537-44841266 Neighboring gene S-phase kinase associated protein 1 pseudogene 4 Neighboring gene long intergenic non-protein coding RNA 1656

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Pei J, et al. Cell Signal, 2012 Mar. PMID 22120523, Free PMC Article
    2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. Hirosawa M, et al. DNA Res, 2001 Feb 28. PMID 11258795
    3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
    4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125851, MGC125852

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein shisa-like-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099294.2 → NP_001092764.1  protein shisa-like-1 precursor

      See identical proteins and their annotated locations for NP_001092764.1

      Status: VALIDATED

      Source sequence(s)
      AL022339, AL031595, AL591914, AL671760
      Consensus CDS
      CCDS43025.1
      UniProtKB/Swiss-Prot
      A6NHP0, A9Z1Z0, Q3SXP7, Q3SXP8, Q5JZ71, Q9BYB5
      Related
      ENSP00000370568.4, ENST00000381176.5
      Conserved Domains (1) summary
      pfam13908
      Location:31 → 71
      Shisa; Wnt and FGF inhibitory regulator

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      44243665..44331714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005261790.4 → XP_005261847.1  protein shisa-like-1 isoform X1

      See identical proteins and their annotated locations for XP_005261847.1

      UniProtKB/Swiss-Prot
      A6NHP0, A9Z1Z0, Q3SXP7, Q3SXP8, Q5JZ71, Q9BYB5
      Conserved Domains (1) summary
      pfam13908
      Location:31 → 71
      Shisa; Wnt and FGF inhibitory regulator

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      44727485..44815559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326058.1 → XP_054182033.1  protein shisa-like-1 isoform X1

      UniProtKB/Swiss-Prot
      A6NHP0, A9Z1Z0, Q3SXP7, Q3SXP8, Q5JZ71, Q9BYB5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SXP7.2 GenPept UniProtKB/Swiss-Prot:Q3SXP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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