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    DOCK1 dedicator of cytokinesis 1 [ Homo sapiens (human) ]

    Gene ID: 1793, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DOCK1provided by HGNC
    Official Full Name
    dedicator of cytokinesis 1provided by HGNC
    Primary source
    HGNC:HGNC:2987
    See related
    Ensembl:ENSG00000150760 MIM:601403; AllianceGenome:HGNC:2987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ced5; DOCK180
    Summary
    This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DOCK1 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (126905428..127452516)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (127789114..128347493)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (128593997..129250780)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD60 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:128581076-128581576 Neighboring gene uncharacterized LOC105378550 Neighboring gene uncharacterized LOC124900289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:128595018-128595766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:128599458-128599958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:128599959-128600459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:128608337-128608885 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:128798279-128799478 Neighboring gene uncharacterized LOC107984059 Neighboring gene uncharacterized LOC105378552 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128868600-128869799 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128936224-128937423 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:128946487-128947686 Neighboring gene inhibitory synaptic factor 2A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:129078632-129079159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4196 Neighboring gene uncharacterized LOC105378551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129190073-129190574 Neighboring gene uncharacterized LOC124902524 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:129262060-129262560 Neighboring gene neuropeptide S Neighboring gene forkhead box I2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma. Zhang W, et al. Mol Med Rep, 2020 Aug. PMID 32626999, Free PMC Article
    2. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. McDonald MN, et al. J Cachexia Sarcopenia Muscle, 2017 Jun. PMID 28044437, Free PMC Article
    3. CRK SH3N Domain Diminishes Cell Invasiveness of Non-Small Cell Lung Cancer. Pezeshkpour GH, et al. Genes Cancer, 2013 Jul. PMID 24167658, Free PMC Article
    4. Solution structure of the SH3 domain of DOCK180. Liu X, et al. Proteins, 2013 May. PMID 23239367
    5. Overexpression of dedicator of cytokinesis I (Dock180) in ovarian cancer correlated with aggressive phenotype and poor patient survival. Zhao F, et al. Histopathology, 2011 Dec. PMID 22175896

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic change investigation in DOCK1 gene in an Iranian family with sign and symptoms of temporomandibular joint disorder (TMD).
      Title: Genetic change investigation in DOCK1 gene in an Iranian family with sign and symptoms of temporomandibular joint disorder (TMD).
    2. ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
      Title: ESRP1 controls biogenesis and function of a large abundant multiexon circRNA.
    3. DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
      Title: DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway.
    4. CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
      Title: CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.
    5. LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
      Title: LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
    6. Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.
      Title: Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.
    7. TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma.
      Title: TBOPP enhances the anticancer effect of cisplatin by inhibiting DOCK1 in renal cell carcinoma.
    8. Identifying and treating ROBO1(-ve) /DOCK1(+ve) prostate cancer: An aggressive cancer subtype prevalent in African American patients.
      Title: Identifying and treating ROBO1(-ve) /DOCK1(+ve) prostate cancer: An aggressive cancer subtype prevalent in African American patients.
    9. CircDOCK1 affected the progression of BC via modulation of circDOCK1/hsa-miR-132-3p/Sox5 pathway.
      Title: Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway.
    10. DOCK180 has an indispensable role in pregnancy establishment as knocking down Dock180 abrogates pregnancy by a consolidated impact on decidualization and angiogenesis by regulating AIRE nuclear entry.
      Title: Silencing of dedicator of cytokinesis (DOCK180) obliterates pregnancy by interfering with decidualization due to blockage of nuclear entry of autoimmune regulator (AIRE).
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
    EBI GWAS Catalog
    Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
    EBI GWAS Catalog
    Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis, engulfment TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 1
    Names
    180 kDa protein downstream of CRK
    DOwnstream of CrK

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033919.3 RefSeqGene

      Range
      5002..552090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290223.2 → NP_001277152.2  dedicator of cytokinesis protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      Consensus CDS
      CCDS76359.1
      UniProtKB/TrEMBL
      A0A096LNH6, A0A2X0U2H5
      Related
      ENSP00000485033.1, ENST00000623213.2

    2. NM_001377543.1 → NP_001364472.1  dedicator of cytokinesis protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:424 → 619
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 416
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1214 → 1666
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    3. NM_001377544.1 → NP_001364473.1  dedicator of cytokinesis protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:436 → 631
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1226 → 1624
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      pfam16172
      Location:84 → 428
      DOCK_N; DOCK N-terminus
      cl17036
      Location:13 → 80
      SH3; Src Homology 3 domain superfamily

    4. NM_001377546.1 → NP_001364475.1  dedicator of cytokinesis protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:445 → 640
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 437
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1235 → 1593
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    5. NM_001377547.1 → NP_001364476.1  dedicator of cytokinesis protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:403 → 598
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1193 → 1591
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 417
      DOCK_N; DOCK N-terminus

    6. NM_001377548.1 → NP_001364477.1  dedicator of cytokinesis protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:396 → 591
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1186 → 1584
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      pfam16172
      Location:44 → 388
      DOCK_N; DOCK N-terminus
      cl17036
      Location:16 → 40
      SH3; Src Homology 3 domain superfamily

    7. NM_001377550.1 → NP_001364479.1  dedicator of cytokinesis protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd11707
      Location:1181 → 1579
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 416
      DOCK_N; DOCK N-terminus
      cl14603
      Location:424 → 586
      C2; C2 domain

    8. NM_001377553.1 → NP_001364482.1  dedicator of cytokinesis protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:424 → 619
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 416
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1214 → 1572
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    9. NM_001377554.1 → NP_001364483.1  dedicator of cytokinesis protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:373 → 568
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1163 → 1561
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 365
      DOCK_N; DOCK N-terminus

    10. NM_001377556.1 → NP_001364485.1  dedicator of cytokinesis protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:424 → 619
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 416
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1214 → 1547
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    11. NM_001377558.1 → NP_001364487.1  dedicator of cytokinesis protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:373 → 568
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1145 → 1543
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 365
      DOCK_N; DOCK N-terminus

    12. NM_001377560.1 → NP_001364489.1  dedicator of cytokinesis protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:160 → 355
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:950 → 1348
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      pfam16172
      Location:44 → 152
      DOCK_N; DOCK N-terminus
      cl17036
      Location:13 → 43
      SH3; Src Homology 3 domain superfamily

    13. NM_001377561.1 → NP_001364490.1  dedicator of cytokinesis protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL359094, AL390920, AL607029, BX470155, BX470201
      Conserved Domains (3) summary
      cd08694
      Location:445 → 640
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 437
      DOCK_N; DOCK N-terminus

    14. NM_001380.5 → NP_001371.2  dedicator of cytokinesis protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL157711, AL355316, AL359094, AL390920, AL607029, BX470155, BX470201
      Consensus CDS
      CCDS73222.1
      UniProtKB/Swiss-Prot
      A9Z1Z5, Q14185
      UniProtKB/TrEMBL
      A0A2X0U2H5
      Related
      ENSP00000280333.6, ENST00000280333.9
      Conserved Domains (4) summary
      cd08694
      Location:424 → 619
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1214 → 1612
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      cd12051
      Location:13 → 68
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:72 → 416
      DOCK_N; DOCK N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      126905428..127452516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424701.1 → XP_047280657.1  dedicator of cytokinesis protein 1 isoform X6

    2. XM_047424703.1 → XP_047280659.1  dedicator of cytokinesis protein 1 isoform X9

    3. XM_017015813.3 → XP_016871302.1  dedicator of cytokinesis protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A2X0U2H5

    4. XM_011539422.4 → XP_011537724.1  dedicator of cytokinesis protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:467 → 662
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1257 → 1655
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      cd12051
      Location:37 → 90
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:94 → 459
      DOCK_N; DOCK N-terminus

    5. XM_017015814.2 → XP_016871303.1  dedicator of cytokinesis protein 1 isoform X4

    6. XM_047424700.1 → XP_047280656.1  dedicator of cytokinesis protein 1 isoform X5

    7. XM_017015817.1 → XP_016871306.1  dedicator of cytokinesis protein 1 isoform X7

    8. XM_047424702.1 → XP_047280658.1  dedicator of cytokinesis protein 1 isoform X8

    9. XM_011539424.2 → XP_011537726.1  dedicator of cytokinesis protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A2X0U2H5
      Conserved Domains (4) summary
      cd08694
      Location:439 → 634
      C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins
      cd11707
      Location:1229 → 1627
      DHR2_DOCK1; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 1
      pfam16172
      Location:66 → 431
      DOCK_N; DOCK N-terminus
      cl17036
      Location:9 → 62
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_007061946.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      127789114..128347493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364961.1 → XP_054220936.1  dedicator of cytokinesis protein 1 isoform X6

    2. XM_054364964.1 → XP_054220939.1  dedicator of cytokinesis protein 1 isoform X9

    3. XM_054364957.1 → XP_054220932.1  dedicator of cytokinesis protein 1 isoform X2

    4. XM_054364956.1 → XP_054220931.1  dedicator of cytokinesis protein 1 isoform X1

    5. XM_054364959.1 → XP_054220934.1  dedicator of cytokinesis protein 1 isoform X4

    6. XM_054364960.1 → XP_054220935.1  dedicator of cytokinesis protein 1 isoform X5

    7. XM_054364962.1 → XP_054220937.1  dedicator of cytokinesis protein 1 isoform X7

    8. XM_054364963.1 → XP_054220938.1  dedicator of cytokinesis protein 1 isoform X8

    9. XM_054364958.1 → XP_054220933.1  dedicator of cytokinesis protein 1 isoform X3

    RNA

    1. XR_008488170.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14185.2 GenPept UniProtKB/Swiss-Prot:Q14185

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