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    CDK19 cyclin dependent kinase 19 [ Homo sapiens (human) ]

    Gene ID: 23097, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CDK19provided by HGNC
    Official Full Name
    cyclin dependent kinase 19provided by HGNC
    Primary source
    HGNC:HGNC:19338
    See related
    Ensembl:ENSG00000155111 MIM:614720; AllianceGenome:HGNC:19338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3
    Summary
    This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDK19 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (110609978..110815855, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111788546..111994459, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110931181..111137058, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24935 Neighboring gene abhydrolase domain containing 10, depalmitoylase pseudogene Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110967777-110968713 Neighboring gene ribosomal protein S20 pseudogene 18 Neighboring gene uncharacterized LOC124901502 Neighboring gene RNA, U6 small nuclear 957, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24937 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111135767-111136319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24938 Neighboring gene MPRA-validated peak6028 silencer Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene RNA, U6 small nuclear 1115, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 40C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. Audetat KA, et al. Mol Cell Biol, 2017 Jul 1. PMID 28416637, Free PMC Article
    2. Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. Cai X, et al. BMC Gastroenterol, 2021 Oct 14. PMID 34649520, Free PMC Article
    3. A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms. Yang S, et al. Cold Spring Harb Mol Case Stud, 2021 Apr. PMID 33568421, Free PMC Article
    4. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants. Zarate YA, et al. Genet Med, 2021 Jun. PMID 33495529
    5. Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer. Becker F, et al. Int J Cancer, 2020 Jan 15. PMID 31271443

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
      Title: CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
    2. CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.
      Title: CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.
    3. Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
      Title: Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
    4. Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.
      Title: Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.
    5. CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.
      Title: CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.
    6. A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.
      Title: A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.
    7. Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.
      Title: Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.
    8. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
      Title: CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
    9. ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.
      Title: ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.
    10. CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC.
      Title: CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Developmental and epileptic encephalopathy, 87
    MedGen: C5394501 OMIM: 618916 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1028

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CKM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 19
    Names
    CDC2-related protein kinase 6
    CDK8-like cyclin-dependent kinase
    cell division cycle 2-like 6 (CDK8-like)
    cell division cycle 2-like protein kinase 6
    cell division protein kinase 19
    cyclin-dependent kinase (CDC2-like) 11
    cyclin-dependent kinase 11
    death-preventing kinase
    NP_001287889.1
    NP_001287892.1
    NP_001287893.1
    NP_055891.1
    XP_005266928.1
    XP_011533932.2
    XP_024302144.2
    XP_024302145.1
    XP_024302146.1
    XP_024302148.1
    XP_047274421.1
    XP_047274423.1
    XP_047274424.1
    XP_047274425.1
    XP_047274426.1
    XP_047274427.1
    XP_047274428.1
    XP_047274429.1
    XP_054210782.1
    XP_054210783.1
    XP_054210784.1
    XP_054210785.1
    XP_054210786.1
    XP_054210787.1
    XP_054210788.1
    XP_054210789.1
    XP_054210790.1
    XP_054210791.1
    XP_054210792.1
    XP_054210793.1
    XP_054210794.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300960.2 → NP_001287889.1  cyclin-dependent kinase 19 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AB028951, AY028424, JX028238, Z84480
      UniProtKB/TrEMBL
      I6W807
      Conserved Domains (2) summary
      smart00220
      Location:22 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:18 → 291
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001300963.2 → NP_001287892.1  cyclin-dependent kinase 19 isoform 3

      See identical proteins and their annotated locations for NP_001287892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AB028951, BC024247, Z84480
      Consensus CDS
      CCDS75503.1
      UniProtKB/TrEMBL
      A8K8J5
      Related
      ENSP00000317665.3, ENST00000323817.7
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001300964.2 → NP_001287893.1  cyclin-dependent kinase 19 isoform 3

      See identical proteins and their annotated locations for NP_001287893.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AB028951, DB030002
      Consensus CDS
      CCDS75503.1
      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain

    4. NM_015076.5 → NP_055891.1  cyclin-dependent kinase 19 isoform 1

      See identical proteins and their annotated locations for NP_055891.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB028951, AY028424, Z84480
      Consensus CDS
      CCDS5085.1
      UniProtKB/Swiss-Prot
      Q5JQZ7, Q5JR00, Q8TC78, Q9BWU1, Q9UPX2
      UniProtKB/TrEMBL
      A8K8J5
      Related
      ENSP00000357907.3, ENST00000368911.8
      Conserved Domains (1) summary
      cd07867
      Location:18 → 335
      STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      110609978..110815855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418470.1 → XP_047274426.1  cyclin-dependent kinase 19 isoform X6

    2. XM_011535630.3 → XP_011533932.2  cyclin-dependent kinase 19 isoform X4

      UniProtKB/TrEMBL
      F6QTA4
      Related
      ENSP00000410604.3, ENST00000413605.6

    3. XM_024446376.2 → XP_024302144.2  cyclin-dependent kinase 19 isoform X2

    4. XM_047418467.1 → XP_047274423.1  cyclin-dependent kinase 19 isoform X2

    5. XM_047418469.1 → XP_047274425.1  cyclin-dependent kinase 19 isoform X3

    6. XM_024446377.2 → XP_024302145.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain

    7. XM_024446380.2 → XP_024302148.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain

    8. XM_024446378.2 → XP_024302146.1  cyclin-dependent kinase 19 isoform X2

      UniProtKB/TrEMBL
      A8K8J5
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain

    9. XM_047418468.1 → XP_047274424.1  cyclin-dependent kinase 19 isoform X2

    10. XM_047418465.1 → XP_047274421.1  cyclin-dependent kinase 19 isoform X1

    11. XM_047418471.1 → XP_047274427.1  cyclin-dependent kinase 19 isoform X7

    12. XM_005266871.4 → XP_005266928.1  cyclin-dependent kinase 19 isoform X5

      See identical proteins and their annotated locations for XP_005266928.1

      UniProtKB/TrEMBL
      B4DUB1, Q9UFE3
      Conserved Domains (1) summary
      cl21453
      Location:28 → 211
      PKc_like; Protein Kinases, catalytic domain

    13. XM_047418472.1 → XP_047274428.1  cyclin-dependent kinase 19 isoform X7

    14. XM_047418473.1 → XP_047274429.1  cyclin-dependent kinase 19 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      111788546..111994459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354815.1 → XP_054210790.1  cyclin-dependent kinase 19 isoform X6

    2. XM_054354813.1 → XP_054210788.1  cyclin-dependent kinase 19 isoform X4

      UniProtKB/TrEMBL
      F6QTA4

    3. XM_054354807.1 → XP_054210782.1  cyclin-dependent kinase 19 isoform X2

    4. XM_054354812.1 → XP_054210787.1  cyclin-dependent kinase 19 isoform X3

    5. XM_054354819.1 → XP_054210794.1  cyclin-dependent kinase 19 isoform X2

    6. XM_054354810.1 → XP_054210785.1  cyclin-dependent kinase 19 isoform X2

    7. XM_054354809.1 → XP_054210784.1  cyclin-dependent kinase 19 isoform X2

    8. XM_054354808.1 → XP_054210783.1  cyclin-dependent kinase 19 isoform X2

    9. XM_054354811.1 → XP_054210786.1  cyclin-dependent kinase 19 isoform X2

    10. XM_054354816.1 → XP_054210791.1  cyclin-dependent kinase 19 isoform X7

    11. XM_054354814.1 → XP_054210789.1  cyclin-dependent kinase 19 isoform X5

      UniProtKB/TrEMBL
      B4DUB1

    12. XM_054354817.1 → XP_054210792.1  cyclin-dependent kinase 19 isoform X7

    13. XM_054354818.1 → XP_054210793.1  cyclin-dependent kinase 19 isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BWU1.1 GenPept UniProtKB/Swiss-Prot:Q9BWU1

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