SCGB1A1 secretoglobin family 1A member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCGB1A1provided by HGNC
Official Full Name: secretoglobin family 1A member 1provided by HGNC
Primary source: HGNC:HGNC:12523
See related: Ensembl:ENSG00000149021 MIM:192020; AllianceGenome:HGNC:12523
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
Summary: This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
Expression: Restricted expression toward lung (RPKM 1367.3) See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (62419033..62423195)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (62408482..62412645)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (62186505..62190667)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining.
Title: Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining.
CC16 drives VLA-2-dependent SPLUNC1 expression.
Title: CC16 drives VLA-2-dependent SPLUNC1 expression.
Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life.
Title: Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life.
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Title: Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes.
Title: Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes.
CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study.
Title: CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study.
Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection.
Title: Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection.
Urinary CC16, a potential indicator of lung integrity and inflammation, increases in children after short-term exposure to PM2.5/PM10 and is driven by the CC16 38GG genotype.
Title: Urinary CC16, a potential indicator of lung integrity and inflammation, increases in children after short-term exposure to PM(2.5)/PM(10) and is driven by the CC16 38GG genotype.
Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis.
Title: Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis.
A rapid point of care CC16 kit for screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis.
Title: A rapid point of care CC16 kit for screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UGB (e-PCR)
- UniSTS:13160

RH71458 (e-PCR)
- UniSTS:16856

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info
enables polychlorinated biphenyl binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	TAS Traceable Author Statement more info	PubMed
involved_in female pregnancy	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-5 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
involved_in response to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to ozone	IEA Inferred from Electronic Annotation more info
involved_in response to silicon dioxide	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uteroglobin

Names: Uteroglobin (club-cell specific 10-kD protein); blastokinin; club cell 10 kDa secretory protein; club cell phospholipid-binding protein; club cell protein 16; club cells 10 kDa secretory protein; club secretory protein 16; secretoglobin, family 1A, member 1 (uteroglobin); urinary protein 1; urine protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.