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    Pierce2 piercer of microtubule wall 2 [ Mus musculus (house mouse) ]

    Gene ID: 546143, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Pierce2provided by MGI
    Official Full Name
    piercer of microtubule wall 2provided by MGI
    Primary source
    MGI:MGI:3648770
    See related
    Ensembl:ENSMUSG00000086158 AllianceGenome:MGI:3648770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5918; Ccpg1os; EG546143
    Summary
    Involved in axoneme assembly; determination of left/right symmetry; and flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in embryo and node. Orthologous to human PIERCE2 (piercer of microtubule wall 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 64.7), kidney adult (RPKM 7.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pierce2 in Genome Data Viewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72886999..72892658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72979724..72985376, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24618 Neighboring gene pygopus 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:72809821-72810010 Neighboring gene dynein axonemal assembly factor 4 Neighboring gene predicted gene, 23567 Neighboring gene STARR-positive B cell enhancer ABC_E3843 Neighboring gene STARR-seq mESC enhancer starr_24620 Neighboring gene cell cycle progression 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class B Neighboring gene Pigb opposite strand 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
    2. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
    3. De novo identification of mammalian ciliary motility proteins using cryo-EM. Gui M, et al. Cell, 2021 Nov 11. PMID 34715025, Free PMC Article
    4. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    5. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    piercer of microtubule wall 2 protein
    Names
    cell cycle progression 1, opposite strand
    uncharacterized protein C15orf65 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198789.1 → NP_001185718.1  piercer of microtubule wall 2 protein

      See identical proteins and their annotated locations for NP_001185718.1

      Status: VALIDATED

      Source sequence(s)
      AC158997, AW125236, BC048630
      Consensus CDS
      CCDS72276.1
      UniProtKB/Swiss-Prot
      V9GXK1
      Related
      ENSMUSP00000139187.2, ENSMUST00000124565.4
      Conserved Domains (1) summary
      pfam14892
      Location:59 → 110
      DUF4490; Domain of unknown function (DUF4490)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      72886999..72892658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155122.1 → XP_036011015.1  piercer of microtubule wall 2 protein isoform X2

      UniProtKB/TrEMBL
      A0A9L6KDU8
      Related
      ENSMUSP00000159587.1, ENSMUST00000249120.1
      Conserved Domains (1) summary
      pfam14892
      Location:39 → 90
      DUF4490; Domain of unknown function (DUF4490)

    2. XM_036155121.1 → XP_036011014.1  piercer of microtubule wall 2 protein isoform X1

      Conserved Domains (1) summary
      pfam14892
      Location:71 → 122
      DUF4490; Domain of unknown function (DUF4490)

    3. XM_036155123.1 → XP_036011016.1  piercer of microtubule wall 2 protein isoform X2

      UniProtKB/TrEMBL
      A0A9L6KDU8
      Conserved Domains (1) summary
      pfam14892
      Location:39 → 90
      DUF4490; Domain of unknown function (DUF4490)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    V9GXK1.1 GenPept UniProtKB/Swiss-Prot:V9GXK1

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