Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdhaprovided by MGI
Official Full Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by MGI
Primary source: MGI:MGI:1914195
See related: Ensembl:ENSMUSG00000021577 AllianceGenome:MGI:1914195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FP; SDH2; SDHF; 4921513A11; 1500032O14Rik; 2310034D06Rik
Summary: Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to contribute to succinate dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone; nervous system development; and succinate metabolic process. Located in mitochondrial inner membrane and myelin sheath. Part of respiratory chain complex II (succinate dehydrogenase). Is active in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in heart adult (RPKM 297.9), kidney adult (RPKM 187.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.15 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (74470374..74498359, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (74322255..74350240, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutation of the FpSDH target tyrosine abolishes the capacity of mitochondria to adjust metabolism upon nutrient restriction, hypoxia/reoxygenation, and T cell activation, demonstrating the physiological relevance of this adaptive response.
Title: ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.
Tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
Title: Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Data show that SdhA is required for preventing AIM2 inflammasome activation.
Title: Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.
Data show that two subunits of complex II (succinate dehydrogenase, or SDH), SDHA and SDHB, interacted specifically with SIRT3.
Title: Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.
Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes.
Title: [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sdha (e-PCR), detects polymorphism
- UniSTS:507208

D17986 (e-PCR)
- UniSTS:124757

RH127008 (e-PCR)
- UniSTS:209773

NoName (e-PCR)
- UniSTS:237052

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
contributes_to succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to succinate dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	NAS Non-traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	ISS Inferred from Sequence or Structural Similarity more info
involved_in succinate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in succinate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Names: E3-10 Sdha; flavoprotein subunit of complex II; malate dehydrogenase [quinone] flavoprotein subunit

NP_075770.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023281.1 → NP_075770.1 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_075770.1

Status: VALIDATED

Source sequence(s)

AK010561, AK034928

Consensus CDS

CCDS26643.1

UniProtKB/Swiss-Prot

Q0QF19, Q3UH25, Q3UKP7, Q3V4B1, Q8K2B3, Q921P5, Q9Z1Z4

Related

ENSMUSP00000022062.8, ENSMUST00000022062.8

Conserved Domains (3) summary

PTZ00139
Location:35 → 664

PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional

pfam02910
Location:513 → 664

Succ_DH_flav_C; Fumarate reductase flavoprotein C-term

cl21454
Location:85 → 518

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins