Camkv CaM kinase-like vesicle-associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camkvprovided by MGI
Official Full Name: CaM kinase-like vesicle-associatedprovided by MGI
Primary source: MGI:MGI:2384296
See related: Ensembl:ENSMUSG00000032936 AllianceGenome:MGI:2384296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1G5
Summary: Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in modulation of chemical synaptic transmission and regulation of modification of postsynaptic structure. Is active in glutamatergic synapse. Is expressed in brain; phalanx; and spinal cord. Orthologous to human CAMKV (CaM kinase like vesicle associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 94.6), frontal lobe adult (RPKM 87.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107813097..107826882)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107935851..107949691)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Camkv has a role in activity-dependent maintenance of dendritic spines
Title: The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caM kinase-like vesicle-associated protein

Names: vesicle-associated calmodulin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409937.1 → NP_001396866.1 caM kinase-like vesicle-associated protein

Status: VALIDATED

Source sequence(s)

AL731808

UniProtKB/Swiss-Prot

Q3UHL1, Q8VD20
NM_145621.3 → NP_663596.1 caM kinase-like vesicle-associated protein

See identical proteins and their annotated locations for NP_663596.1

Status: VALIDATED

Source sequence(s)

AL731808

Consensus CDS

CCDS40763.1

UniProtKB/Swiss-Prot

Q3UHL1, Q8VD20

UniProtKB/TrEMBL

A0A0A6YW88

Related

ENSMUSP00000040430.9, ENSMUST00000035700.14

Conserved Domains (2) summary

cd14088
Location:22 → 286

STKc_CaMK_like; Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases

pfam17823
Location:397 → 511

DUF5585; Family of unknown function (DUF5585)