Umodl1 uromodulin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Umodl1provided by MGI
Official Full Name: uromodulin-like 1provided by MGI
Primary source: MGI:MGI:1929785
See related: Ensembl:ENSMUSG00000054134 AllianceGenome:MGI:1929785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D17Ertd488e
Summary: Predicted to enable calcium ion binding activity and peptidase inhibitor activity. Acts upstream of or within several processes, including cellular response to gonadotropin-releasing hormone; regulation of granulosa cell apoptotic process; and regulation of ovarian follicle development. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human UMODL1 (uromodulin like 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in testis adult (RPKM 3.0), ovary adult (RPKM 0.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.8 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31173614..31229684)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (30954648..31010710)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Umodl1 accelerates follicle depletion and subsequent ovarian degeneration.
Title: Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.
At age 3 weeks, Umodl1 (N8) mRNA shows a smooth gradation from high apical to low basal within the layer of mature olfactory sensory neuron layer of the mouse olfactory epithelium. Whether this is due to cell position or cell age is not known.
Title: Differentially expressed transcripts from phenotypically identified olfactory sensory neurons.
During embryonic development expression of the Umodl1 gene is detectable only in the olfactory epithelium and vomeronasal organ starting at embryonic day 16.5. suggest that olfactorin may play a role in correct olfactory axon navigation to the brain.
Title: UMODL1/Olfactorin is an extracellular membrane-bound molecule with a restricted spatial expression in olfactory and vomeronasal neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Umodl1 (e-PCR), detects polymorphism
- UniSTS:234021

AU021713 (e-PCR)
- UniSTS:167216

UniSTS:259168 (e-PCR)
- UniSTS:259168

Umodl1 (e-PCR), detects polymorphism
- UniSTS:259168

Umodl1 (e-PCR), detects polymorphism
- UniSTS:265072

NoName (e-PCR)
- UniSTS:492755

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adipose tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to gonadotropin-releasing hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organismal reproductive process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of developmental process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of granulosa cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of ovarian follicle development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of reproductive process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within single fertilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uromodulin-like 1

Names: olfactorin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177465.4 → NP_803416.2 uromodulin-like 1 precursor

See identical proteins and their annotated locations for NP_803416.2

Status: VALIDATED

Source sequence(s)

AY771617, BC051427

Consensus CDS

CCDS37543.1

UniProtKB/Swiss-Prot

Q5DID3

Related

ENSMUSP00000110202.2, ENSMUST00000114555.3

Conserved Domains (8) summary

smart00179
Location:502 → 529

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:1025 → 1265

ZP; Zona pellucida (ZP) domain

cd00054
Location:930 → 973

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00041
Location:737 → 814

fn3; Fibronectin type III domain

pfam00095
Location:120 → 158

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

pfam00100
Location:1158 → 1265

Zona_pellucida; Zona pellucida-like domain

pfam01390
Location:391 → 467

SEA; SEA domain

cl02507
Location:829 → 895

SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

31173614..31229684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524614.3 → XP_006524677.1 uromodulin-like 1 isoform X1

See identical proteins and their annotated locations for XP_006524677.1

UniProtKB/Swiss-Prot

Q5DID1, Q5DID2, Q5DID3

Related

ENSMUSP00000157726.2, ENSMUST00000237889.2

Conserved Domains (7) summary

smart00179
Location:502 → 529

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:901 → 944

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00041
Location:708 → 784

fn3; Fibronectin type III domain

pfam00095
Location:118 → 158

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

pfam00100
Location:996 → 1236

Zona_pellucida; Zona pellucida-like domain

cl02507
Location:800 → 866

SEA; SEA domain

cl21522
Location:306 → 370

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...