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    Ssr4 signal sequence receptor, delta [ Mus musculus (house mouse) ]

    Gene ID: 20832, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ssr4provided by MGI
    Official Full Name
    signal sequence receptor, deltaprovided by MGI
    Primary source
    MGI:MGI:1099464
    See related
    Ensembl:ENSMUSG00000002014 AllianceGenome:MGI:1099464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trap; SSR-delta; TRAP-delta
    Summary
    Predicted to be located in endoplasmic reticulum. Predicted to be part of Sec61 translocon complex. Predicted to be active in endomembrane system. Is expressed in several structures, including gut; jaw; musculoskeletal system; nasal capsule; and submandibular gland primordium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iy. Orthologous to human SSR4 (signal sequence receptor subunit 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 108.4), duodenum adult (RPKM 90.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ssr4 in Genome Data Viewer
    Location:
    X A7.3; X 37.41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72830778..72834432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73787023..73790828)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich protein specific kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E11049 Neighboring gene isocitrate dehydrogenase 3 (NAD+), gamma Neighboring gene STARR-seq mESC enhancer starr_47355 Neighboring gene PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_47357 Neighboring gene predicted gene, 23615 Neighboring gene STARR-seq mESC enhancer starr_47358 Neighboring gene STARR-seq mESC enhancer starr_47359 Neighboring gene L1 cell adhesion molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary. Holthuis JC, et al. Biochem J, 1995 Nov 15. PMID 7492314, Free PMC Article
    2. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, et al. Genomics, 1997 Aug 15. PMID 9286695
    3. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
    4. Hepatic lipase maturation: a partial proteome of interacting factors. Doolittle MH, et al. J Lipid Res, 2009 Jun. PMID 19136429, Free PMC Article
    5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit delta
    Names
    signal sequence receptor subunit delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166480.3 → NP_001159952.1  translocon-associated protein subunit delta isoform 1 precursor

      See identical proteins and their annotated locations for NP_001159952.1

      Status: VALIDATED

      Source sequence(s)
      AL672094
      Consensus CDS
      CCDS53099.1
      UniProtKB/TrEMBL
      Q9D8L3, Q9DC94
      Related
      ENSMUSP00000131386.2, ENSMUST00000166518.8
      Conserved Domains (1) summary
      pfam05404
      Location:22 → 172
      TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

    2. NM_001358212.2 → NP_001345141.1  translocon-associated protein subunit delta isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL672094
      Conserved Domains (1) summary
      pfam05404
      Location:22 → 117
      TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

    3. NM_001358213.2 → NP_001345142.1  translocon-associated protein subunit delta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672094
      Conserved Domains (1) summary
      pfam05404
      Location:1 → 109
      TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

    4. NM_001426003.1 → NP_001412932.1  translocon-associated protein subunit delta isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL672094

    5. NM_001426004.1 → NP_001412933.1  translocon-associated protein subunit delta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672094

    6. NM_009279.5 → NP_033305.1  translocon-associated protein subunit delta isoform 2 precursor

      See identical proteins and their annotated locations for NP_033305.1

      Status: VALIDATED

      Source sequence(s)
      AL672094
      Consensus CDS
      CCDS30213.1
      UniProtKB/Swiss-Prot
      Q62186
      UniProtKB/TrEMBL
      Q3TVJ8, Q9D6F7
      Related
      ENSMUSP00000002090.3, ENSMUST00000002090.3
      Conserved Domains (1) summary
      pfam05404
      Location:22 → 171
      TRAP-delta; Translocon-associated protein, delta subunit precursor (TRAP-delta)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72830778..72834432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62186.1 GenPept UniProtKB/Swiss-Prot:Q62186

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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