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    Uba2 ubiquitin-like modifier activating enzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 50995, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Uba2provided by MGI
    Official Full Name
    ubiquitin-like modifier activating enzyme 2provided by MGI
    Primary source
    MGI:MGI:1858313
    See related
    Ensembl:ENSMUSG00000052997 AllianceGenome:MGI:1858313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arx; Sae2; UBA1; Ubl1a2; Uble1b
    Summary
    Enables SUMO activating enzyme activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Predicted to be located in nucleoplasm. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in branchial arch; embryo; limb; and neural fold. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 54.7), CNS E14 (RPKM 34.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uba2 in Genome Data Viewer
    Location:
    7 B1; 7 19.41 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33840121..33868014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34140697..34168590, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene secretoglobin, family 1B, member 30 Neighboring gene WT1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_18578 Neighboring gene STARR-seq mESC enhancer starr_18579 Neighboring gene STARR-seq mESC enhancer starr_18581 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene programmed cell death 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and regulation of the mammalian SUMO-1 E1 enzyme. Azuma Y, et al. FASEB J, 2001 Aug. PMID 11481243
    2. Biotin-ubiquitin tagging of mammalian proteins in Escherichia coli. Wang T, et al. Protein Expr Purif, 2003 Jul. PMID 12821332
    3. SUMO conjugation and deconjugation. Schwienhorst I, et al. Mol Gen Genet, 2000 Jun. PMID 10905345
    4. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Ban R, et al. Genes Cells, 2011 Jun. PMID 21554500
    5. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. Takahashi H, et al. J Biol Chem, 2005 Feb 18. PMID 15569683

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SUMO binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small protein activating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SUMO activating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SUMO activating enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-activating enzyme subunit 2
    Names
    SUMO1 activating enzyme subunit 2
    Sumo-1 activating enzyme subunit 2
    anthracycline-associated resistance ARX
    ubiquitin-like 1 (sentrin) activating enzyme E1B
    ubiquitin-like 1 (sentrin) activating enzyme subunit 2
    ubiquitin-like 1-activating enzyme E1B
    NP_001405401.1
    NP_001405402.1
    NP_001405403.1
    NP_001405405.1
    NP_057891.1
    XP_017177837.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418472.1 → NP_001405401.1  SUMO-activating enzyme subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX537302

    2. NM_001418473.1 → NP_001405402.1  SUMO-activating enzyme subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX537302

    3. NM_001418474.1 → NP_001405403.1  SUMO-activating enzyme subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX537302

    4. NM_001418476.1 → NP_001405405.1  SUMO-activating enzyme subunit 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      BX537302

    5. NM_016682.3 → NP_057891.1  SUMO-activating enzyme subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_057891.1

      Status: VALIDATED

      Source sequence(s)
      BX537302
      Consensus CDS
      CCDS21136.1
      UniProtKB/Swiss-Prot
      Q3TQN3, Q3U819, Q3U9J5, Q8BVX9, Q9Z1F9
      Related
      ENSMUSP00000099807.5, ENSMUST00000102746.11
      Conserved Domains (4) summary
      cd01489
      Location:19 → 442
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:9 → 175
      ThiF; ThiF family
      pfam14732
      Location:450 → 536
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:547 → 633
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    RNA

    1. NR_184752.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX537302

    2. NR_184753.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX537302

    3. NR_184754.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX537302

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      33840121..33868014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322348.3 → XP_017177837.1  SUMO-activating enzyme subunit 2 isoform X1

      Conserved Domains (3) summary
      cd01489
      Location:19 → 442
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam14732
      Location:450 → 536
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:549 → 578
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1F9.1 GenPept UniProtKB/Swiss-Prot:Q9Z1F9

    Gene LinkOut

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