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    Pcsk7 proprotein convertase subtilisin/kexin type 7 [ Mus musculus (house mouse) ]

    Gene ID: 18554, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Pcsk7provided by MGI
    Official Full Name
    proprotein convertase subtilisin/kexin type 7provided by MGI
    Primary source
    MGI:MGI:107421
    See related
    Ensembl:ENSMUSG00000035382 AllianceGenome:MGI:107421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC7; SPC7
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in early conceptus and oocyte. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in bladder adult (RPKM 616.5), stomach adult (RPKM 205.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcsk7 in Genome Data Viewer
    Location:
    9 A5.2; 9 25.32 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45817745..45843405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45906447..45932107)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45655339-45655522 Neighboring gene beta-site APP cleaving enzyme 1 Neighboring gene ring finger protein 214 Neighboring gene predicted gene, 24646 Neighboring gene STARR-seq mESC enhancer starr_24009 Neighboring gene transgelin Neighboring gene microRNA 7087 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene RIKEN cDNA A830035O19 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Proprotein convertase 7 (PCSK7) reduces apoA-V levels. Ashraf Y, et al. FEBS J, 2020 Aug. PMID 31945259
    2. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Anyetei-Anum EN, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27923657
    3. PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. Sachan V, et al. Metabolism, 2024 Jan. PMID 37967646
    4. Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. Villeneuve P, et al. J Neurochem, 2002 Aug. PMID 12358783
    5. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. Refaie S, et al. J Biol Chem, 2012 Apr 27. PMID 22396549, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
      Title: PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease.
    2. PC7 has a critical role in normal processing of cholecystokinin in mouse brain
      Title: Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain.
    3. PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
      Title: PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
    4. Data show that BDNF and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
      Title: Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
    5. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
      Title: Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
    6. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
      Title: Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
    7. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
      Title: Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 7
    Names
    prohormone convertase 7
    prohormone convertase PC7
    proprotein convertase 7
    proprotein convertase PC7
    subtilisin-like proprotein convertase 7
    subtilisin/kexin-like protease PC7
    NP_001268863.1
    NP_032820.2
    XP_006510151.1
    XP_006510152.1
    XP_036010579.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281934.1 → NP_001268863.1  proprotein convertase subtilisin/kexin type 7 precursor

      See identical proteins and their annotated locations for NP_001268863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC126804, AK165389, BC056456
      Consensus CDS
      CCDS40609.1
      UniProtKB/Swiss-Prot
      O08577, Q61139, Q922W4
      UniProtKB/TrEMBL
      Q3U920
      Related
      ENSMUSP00000150393.2, ENSMUST00000216672.2
      Conserved Domains (3) summary
      cd04059
      Location:144 → 438
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:524 → 611
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:52 → 140
      S8_pro-domain; Peptidase S8 pro-domain

    2. NM_008794.2 → NP_032820.2  proprotein convertase subtilisin/kexin type 7 precursor

      See identical proteins and their annotated locations for NP_032820.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK148416, BC056456
      Consensus CDS
      CCDS40609.1
      UniProtKB/Swiss-Prot
      O08577, Q61139, Q922W4
      UniProtKB/TrEMBL
      Q3U920
      Related
      ENSMUSP00000047508.7, ENSMUST00000039059.8
      Conserved Domains (3) summary
      cd04059
      Location:144 → 438
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:524 → 611
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:52 → 140
      S8_pro-domain; Peptidase S8 pro-domain

    RNA

    1. NR_104055.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon and uses an alternate splice junction in the first exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC126804, BC056456
      Related
      ENSMUST00000215189.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45817745..45843405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510089.3 → XP_006510152.1  proprotein convertase subtilisin/kexin type 7 isoform X3

      Conserved Domains (2) summary
      cd04059
      Location:144 → 377
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam16470
      Location:52 → 140
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_036154686.1 → XP_036010579.1  proprotein convertase subtilisin/kexin type 7 isoform X1

      UniProtKB/Swiss-Prot
      O08577, Q61139, Q922W4
      UniProtKB/TrEMBL
      Q3U920
      Conserved Domains (3) summary
      cd04059
      Location:144 → 438
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:524 → 611
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:52 → 140
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_006510088.5 → XP_006510151.1  proprotein convertase subtilisin/kexin type 7 isoform X2

      Conserved Domains (2) summary
      cd04059
      Location:2 → 223
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:309 → 396
      P_proprotein; Proprotein convertase P-domain

    RNA

    1. XR_004935338.1 RNA Sequence

    2. XR_001778808.3 RNA Sequence

    3. XR_001778807.3 RNA Sequence

    4. XR_870526.4 RNA Sequence

    5. XR_001778810.3 RNA Sequence

    6. XR_001778809.3 RNA Sequence

    7. XR_001778811.3 RNA Sequence

    8. XR_004935342.1 RNA Sequence

    9. XR_004935341.1 RNA Sequence

    10. XR_004935340.1 RNA Sequence

    11. XR_004935339.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61139.2 GenPept UniProtKB/Swiss-Prot:Q61139

    Gene LinkOut

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