Cd5l CD5 antigen-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd5lprovided by MGI
Official Full Name: CD5 antigen-likeprovided by MGI
Primary source: MGI:MGI:1334419
See related: Ensembl:ENSMUSG00000015854 AllianceGenome:MGI:1334419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1/6; AIM; CT2; Pdp; Api6; mAIM; AAC-11; Sp-alpha
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface and plasma membrane. Is expressed in several structures, including central nervous system; immune system; liver; retina; and testis. Orthologous to human CD5L (CD5 molecule like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver E18 (RPKM 55.6), liver E14 (RPKM 35.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.19 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87265188..87278381)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87357881..87371074)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression.
Title: CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression.
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
Title: AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
Title: Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
[CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
Title: [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
CD5L attenuates allergic airway inflammation by expanding CD11c(high) alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2.
Title: CD5L attenuates allergic airway inflammation by expanding CD11c(high) alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2.
AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.
Title: AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.
High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein.
Title: High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein.
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Title: IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
The immunopathological role of apoptosis inhibitor of macrophage (AIM)/CD5L in sepsis.
Title: Therapeutic Targeting of Apoptosis Inhibitor of Macrophage/CD5L in Sepsis.
Our study identifies CD5L as a key pleiotropic inhibitor of chronic liver injury.
Title: CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130363 (e-PCR)
- UniSTS:213647

AF018268 (e-PCR)
- UniSTS:159130

AI047839 (e-PCR)
- UniSTS:178864

Cd5l (e-PCR), detects polymorphism
- UniSTS:141292

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of complement-dependent cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of complement activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CD5 antigen-like

Names: AIM/Spalpha; CT-2; Pdp 1/6; apoptosis inhibitor 6; apoptosis inhibitor expressed by macrophages

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.