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    Chmp3 charged multivesicular body protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66700, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Chmp3provided by MGI
    Official Full Name
    charged multivesicular body protein 3provided by MGI
    Primary source
    MGI:MGI:1913950
    See related
    Ensembl:ENSMUSG00000053119 AllianceGenome:MGI:1913950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    25.1; NEDF; Vps24; CGI-49; D6Ertd286e; 4921505F14Rik; 9130011K15Rik
    Summary
    Predicted to enable several functions, including identical protein binding activity; phospholipid binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; early endosome; and kinetochore microtubule. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in brain; male reproductive gland or organ; metanephros; and neural retinal epithelium. Orthologous to several human genes including CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 24.4), cerebellum adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chmp3 in Genome Data Viewer
    Location:
    6 C1; 6 32.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71520820..71559593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71543831..71582609)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene ring finger protein 103 Neighboring gene STARR-positive B cell enhancer ABC_E8110 Neighboring gene lysine (K)-specific demethylase 3A Neighboring gene STARR-seq mESC enhancer starr_16264 Neighboring gene STARR-seq mESC enhancer starr_16265 Neighboring gene STARR-positive B cell enhancer ABC_E3659 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71583085-71583314 Neighboring gene STARR-positive B cell enhancer ABC_E9095 Neighboring gene peptidylprolyl isomerase A pseudogene 6_731.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. McCullough J, et al. Curr Biol, 2006 Jan 24. PMID 16431367
    2. Analysis of gene expression in the developing mouse retina. Díaz E, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12702772, Free PMC Article
    3. Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. Azmi I, et al. J Cell Biol, 2006 Feb 27. PMID 16505166, Free PMC Article
    4. Membrane scission by the ESCRT-III complex. Wollert T, et al. Nature, 2009 Mar 12. PMID 19234443, Free PMC Article
    5. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multivesicular body assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multivesicular body-lysosome fusion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endosome size IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endosome size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in suppression of viral release by host IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle fusion with vacuole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in viral budding from plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in amphisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    charged multivesicular body protein 3
    Names
    chromatin-modifying protein 3
    neuroendocrine differentiation factor
    vacuolar protein sorting-associated protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355674.1 → NP_001342603.1  charged multivesicular body protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118686
      Conserved Domains (1) summary
      pfam03357
      Location:1 → 161
      Snf7

    2. NM_001355675.1 → NP_001342604.1  charged multivesicular body protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118686
      Conserved Domains (1) summary
      pfam03357
      Location:1 → 161
      Snf7

    3. NM_001361405.1 → NP_001348334.1  charged multivesicular body protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118686, AK014818, BY264596
      Consensus CDS
      CCDS20232.1
      UniProtKB/Swiss-Prot
      Q9CQ10, Q9D2Z2, Q9D7A5
      Related
      ENSMUSP00000068410.3, ENSMUST00000065364.5
      Conserved Domains (1) summary
      pfam03357
      Location:18 → 187
      Snf7

    4. NM_025783.4 → NP_080059.2  charged multivesicular body protein 3 isoform 1

      See identical proteins and their annotated locations for NP_080059.2

      Status: VALIDATED

      Source sequence(s)
      AI848675, AK083562, BY264596
      Consensus CDS
      CCDS20232.1
      UniProtKB/Swiss-Prot
      Q9CQ10, Q9D2Z2, Q9D7A5
      Related
      ENSMUSP00000109815.4, ENSMUST00000059462.12
      Conserved Domains (1) summary
      pfam03357
      Location:18 → 187
      Snf7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71520820..71559593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506481.5 → XP_006506544.1  charged multivesicular body protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006506544.1

      Conserved Domains (1) summary
      cl21588
      Location:1 → 121
      Snf7

    2. XM_030255546.2 → XP_030111406.1  charged multivesicular body protein 3 isoform X1

      Conserved Domains (1) summary
      cl21588
      Location:1 → 121
      Snf7

    3. XM_036152263.1 → XP_036008156.1  charged multivesicular body protein 3 isoform X1

      Conserved Domains (1) summary
      cl21588
      Location:1 → 121
      Snf7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ10.3 GenPept UniProtKB/Swiss-Prot:Q9CQ10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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