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    Cbln2 cerebellin 2 precursor protein [ Mus musculus (house mouse) ]

    Gene ID: 12405, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cbln2provided by MGI
    Official Full Name
    cerebellin 2 precursor proteinprovided by MGI
    Primary source
    MGI:MGI:88282
    See related
    Ensembl:ENSMUSG00000024647 AllianceGenome:MGI:88282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730004O05; 6330593N19Rik
    Summary
    The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cbln2 in Genome Data Viewer
    Location:
    18 E4; 18 58.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (86727226..86736410)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (86711061..86718283)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25453 Neighboring gene predicted gene, 54041 Neighboring gene neuropilin (NRP) and tolloid (TLL)-like 1 Neighboring gene STARR-seq mESC enhancer starr_45283 Neighboring gene STARR-seq mESC enhancer starr_45284 Neighboring gene STARR-seq mESC enhancer starr_45285 Neighboring gene predicted gene, 46615 Neighboring gene DNA methyltransferase 1-associated protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Seigneur E, et al. Mol Psychiatry, 2021 Dec. PMID 34158618, Free PMC Article
    2. Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord. Cagle MC, et al. J Comp Neurol, 2014 Feb 1. PMID 23853053, Free PMC Article
    3. Transcriptomic encoding of sensorimotor transformation in the midbrain. Xie Z, et al. Elife, 2021 Jul 28. PMID 34318750, Free PMC Article
    4. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Seigneur E, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30287486, Free PMC Article
    5. Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes. Yasumura M, et al. J Neurochem, 2012 Jun. PMID 22191730

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
      Title: Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
    2. Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors.
      Title: Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs.
    3. Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
      Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.
    4. Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons.
      Title: Cerebellins are differentially expressed in selective subsets of neurons throughout the brain.
    5. that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord
      Title: Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.
    6. GluRdelta1 stimulated inhibitory synapse formation in the presence of Cbln1 or Cbln2
      Title: Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
    7. These results suggest that Cbln1 and Cbln2 play a role in synapse formation of cortical neurons by interacting with NRXNs containing S4.
      Title: Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of synapse structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of synapse structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spontaneous synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trans-synaptic signaling, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trans-synaptic signaling, modulating synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in trans-synaptic signaling, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic cleft IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in synaptic cleft NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of trans-synaptic protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cerebellin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302356.2 → NP_001289285.1  cerebellin-2 precursor

      See identical proteins and their annotated locations for NP_001289285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC115783
      Consensus CDS
      CCDS29388.1
      UniProtKB/Swiss-Prot
      Q8BGU2
      Related
      ENSMUSP00000068863.4, ENSMUST00000068423.10
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    2. NM_001361142.1 → NP_001348071.1  cerebellin-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC115783
      Consensus CDS
      CCDS29388.1
      UniProtKB/Swiss-Prot
      Q8BGU2
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    3. NM_001361143.1 → NP_001348072.1  cerebellin-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC115783
      Consensus CDS
      CCDS29388.1
      UniProtKB/Swiss-Prot
      Q8BGU2
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    4. NM_001361144.1 → NP_001348073.1  cerebellin-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC115783
      Consensus CDS
      CCDS29388.1
      UniProtKB/Swiss-Prot
      Q8BGU2
      Related
      ENSMUSP00000126810.2, ENSMUST00000169470.2
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    5. NM_001361145.1 → NP_001348074.1  cerebellin-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC115783
      Consensus CDS
      CCDS29388.1
      UniProtKB/Swiss-Prot
      Q8BGU2
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    6. NM_172633.4 → NP_766221.1  cerebellin-2 precursor

      See identical proteins and their annotated locations for NP_766221.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
      Source sequence(s)
      AC115783, AK032112, AK076174, BM948793, BX523565
      Consensus CDS
      CCDS29388.1
      UniProtKB/Swiss-Prot
      Q8BGU2
      Related
      ENSMUSP00000113695.2, ENSMUST00000122079.8
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      86727226..86736410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160955.1 → XP_036016848.1  cerebellin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BGU2
      Related
      ENSMUSP00000113996.2, ENSMUST00000122464.8
      Conserved Domains (1) summary
      cl23878
      Location:86 → 224
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGU2.1 GenPept UniProtKB/Swiss-Prot:Q8BGU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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