Igfbpl1 insulin-like growth factor binding protein-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igfbpl1provided by MGI
Official Full Name: insulin-like growth factor binding protein-like 1provided by MGI
Primary source: MGI:MGI:1933198
See related: Ensembl:ENSMUSG00000035551 AllianceGenome:MGI:1933198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IGFBPL; 2810011G06Rik; 2810453O06Rik
Summary: Predicted to enable insulin-like growth factor binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human IGFBPL1 (insulin like growth factor binding protein like 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 101.0), CNS E14 (RPKM 96.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 24.36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (45809507..45826827, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (45809507..45826827, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To clarify IGFBPL-1 expression profiles during development, study investigated the expression patterns of IGFBPL-1 mRNA in developing mouse brains using in situ hybridization, focusing especially on the forebrain.
Title: Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

Igfbpl1 (e-PCR), detects polymorphism
- UniSTS:506997

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein-like 1

Names: IGFBP-like protein; IGFBP-rP4; IGFBP-related protein 10; insulin-like growth factor-binding-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018741.2 → NP_061211.1 insulin-like growth factor-binding protein-like 1 precursor

See identical proteins and their annotated locations for NP_061211.1

Status: VALIDATED

Source sequence(s)

AB006141, AK012705, AW457842, BY755041

Consensus CDS

CCDS38756.1

UniProtKB/Swiss-Prot

Q80W15

Related

ENSMUSP00000036974.7, ENSMUST00000044297.7

Conserved Domains (4) summary

cd00096
Location:164 → 247

Ig; Immunoglobulin domain

smart00280
Location:106 → 143

KAZAL; Kazal type serine protease inhibitors

pfam07679
Location:147 → 252

I-set; Immunoglobulin I-set domain

pfam00219
Location:52 → 83

IGFBP; Insulin-like growth factor binding protein