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    Zbtb37 zinc finger and BTB domain containing 37 [ Mus musculus (house mouse) ]

    Gene ID: 240869, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zbtb37provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 37provided by MGI
    Primary source
    MGI:MGI:2444467
    See related
    Ensembl:ENSMUSG00000043467 AllianceGenome:MGI:2444467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D430004I08Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in early conceptus and genitourinary system. Orthologous to human ZBTB37 (zinc finger and BTB domain containing 37). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb37 in Genome Data Viewer
    Location:
    1 H2.1; 1 69.75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160830492..160862432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161002922..161034864, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:162836371-162836672 Neighboring gene RING CCCH (C3H) domains 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Neighboring gene predicted gene, 57574 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162964993-162965294 Neighboring gene predicted gene, 26224 Neighboring gene predicted gene, 22489 Neighboring gene growth arrest specific 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356489.1 → NP_001343418.1  zinc finger and BTB domain-containing protein 37

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Consensus CDS
      CCDS15412.1
      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Related
      ENSMUSP00000125417.3, ENSMUST00000159250.9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    2. NM_173424.4 → NP_775600.1  zinc finger and BTB domain-containing protein 37

      See identical proteins and their annotated locations for NP_775600.1

      Status: VALIDATED

      Source sequence(s)
      AC163327
      Consensus CDS
      CCDS15412.1
      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Related
      ENSMUSP00000125253.3, ENSMUST00000162226.9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_151478.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327

    2. NR_151479.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163327

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160830492..160862432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164847.1 → XP_036020740.1  zinc finger and BTB domain-containing protein 37 isoform X3

      UniProtKB/TrEMBL
      F7ALN1
      Conserved Domains (1) summary
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    2. XM_030254006.2 → XP_030109866.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030254021.2 → XP_030109881.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030254007.2 → XP_030109867.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    5. XM_030254027.2 → XP_030109887.1  zinc finger and BTB domain-containing protein 37 isoform X3

      UniProtKB/TrEMBL
      F7ALN1
      Conserved Domains (1) summary
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    6. XM_030254014.2 → XP_030109874.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    7. XM_036164844.1 → XP_036020737.1  zinc finger and BTB domain-containing protein 37 isoform X3

      UniProtKB/TrEMBL
      F7ALN1
      Conserved Domains (1) summary
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    8. XM_030254009.2 → XP_030109869.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    9. XM_036164845.1 → XP_036020738.1  zinc finger and BTB domain-containing protein 37 isoform X3

      UniProtKB/TrEMBL
      F7ALN1
      Related
      ENSMUSP00000129965.3, ENSMUST00000171748.3
      Conserved Domains (1) summary
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    10. XM_011238812.3 → XP_011237114.1  zinc finger and BTB domain-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_011237114.1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    11. XM_011238815.3 → XP_011237117.1  zinc finger and BTB domain-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_011237117.1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    12. XM_030254017.2 → XP_030109877.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    13. XM_036164829.1 → XP_036020722.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    14. XM_030254010.2 → XP_030109870.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    15. XM_030254019.2 → XP_030109879.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
      Conserved Domains (4) summary
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:403 → 425
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 440
      zf-H2C2_2; Zinc-finger double domain

    16. XM_036164837.1 → XP_036020730.1  zinc finger and BTB domain-containing protein 37 isoform X2

      Conserved Domains (1) summary
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    17. XM_036164836.1 → XP_036020729.1  zinc finger and BTB domain-containing protein 37 isoform X2

      Conserved Domains (1) summary
      cd18222
      Location:9 → 131
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    Nucleotide Protein Strain
    Heading Accession and Version

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