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    Trim23 tripartite motif-containing 23 [ Mus musculus (house mouse) ]

    Gene ID: 81003, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Trim23provided by MGI
    Official Full Name
    tripartite motif-containing 23provided by MGI
    Primary source
    MGI:MGI:1933161
    See related
    Ensembl:ENSMUSG00000021712 AllianceGenome:MGI:1933161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arfd1; 6330516O20Rik
    Summary
    Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Predicted to be involved in several processes, including intracellular protein transport; positive regulation of autophagy; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in ureter. Orthologous to human TRIM23 (tripartite motif containing 23). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E18 (RPKM 7.0), frontal lobe adult (RPKM 5.5) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim23 in Genome Data Viewer
    Location:
    13 D1; 13 56.35 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104315187..104339983)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104178839..104203475)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Neighboring gene STARR-positive B cell enhancer ABC_E3099 Neighboring gene trafficking protein particle complex 13 Neighboring gene STARR-positive B cell enhancer ABC_E8896 Neighboring gene STARR-positive B cell enhancer ABC_E385 Neighboring gene STARR-seq mESC enhancer starr_35535 Neighboring gene shieldin complex subunit 3 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4090 Neighboring gene centromere protein K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tripartite motif containing 23 functions as a critical regulator in macrophages to control the pathological feature of diabetic nephropathy. Quan W, et al. Int Urol Nephrol, 2023 May. PMID 36449224
    2. Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Kudryashova E, et al. Hum Mol Genet, 2009 Apr 1. PMID 19155210, Free PMC Article
    3. The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ. Watanabe M, et al. Elife, 2015 Apr 23. PMID 25905670, Free PMC Article
    4. Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Arimoto K, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20724660, Free PMC Article
    5. Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels. Cao X, et al. J Biol Chem, 2021 Jan-Jun. PMID 33957127, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tripartite motif containing 23 functions as a critical regulator in macrophages to control the pathological feature of diabetic nephropathy.
      Title: Tripartite motif containing 23 functions as a critical regulator in macrophages to control the pathological feature of diabetic nephropathy.
    2. TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2.
      Title: The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM23
    Names
    ADP-ribosylation factor domain protein 1, 64kD
    ADP-ribosylation factor domain-containing protein 1
    GTP-binding protein ARD-1
    RING-type E3 ubiquitin transferase TRIM23
    tripartite motif protein TRIM23
    tripartite motif-containing protein 23
    NP_001348467.1
    NP_001348468.1
    XP_036014122.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361538.1 → NP_001348467.1  E3 ubiquitin-protein ligase TRIM23 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154216, AK039280
      Consensus CDS
      CCDS88515.1
      UniProtKB/Swiss-Prot
      Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7
      Related
      ENSMUSP00000022225.6, ENSMUST00000022225.12
      Conserved Domains (5) summary
      smart00336
      Location:173 → 219
      BBOX; B-Box-type zinc finger
      cd04158
      Location:406 → 574
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      cd00021
      Location:125 → 168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd16645
      Location:28 → 77
      mRING-HC-C3HC3D_TRIM23_C-IX; Modified RING finger, HC subclass (C3HC3D-type), found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl25407
      Location:226 → 370
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    2. NM_001361539.1 → NP_001348468.1  E3 ubiquitin-protein ligase TRIM23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154216
      Consensus CDS
      CCDS88516.1
      Related
      ENSMUSP00000070767.6, ENSMUST00000069187.12
      Conserved Domains (5) summary
      smart00336
      Location:173 → 216
      BBOX; B-Box-type zinc finger
      cd04158
      Location:345 → 513
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      cd00021
      Location:125 → 168
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd16645
      Location:28 → 77
      mRING-HC-C3HC3D_TRIM23_C-IX; Modified RING finger, HC subclass (C3HC3D-type), found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl25407
      Location:214 → 309
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104315187..104339983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158229.1 → XP_036014122.1  E3 ubiquitin-protein ligase TRIM23 isoform X1

      Conserved Domains (5) summary
      smart00502
      Location:259 → 403
      BBC; B-Box C-terminal domain
      cd16645
      Location:61 → 110
      mRING-HC-C3HC3D_TRIM23_C-IX; Modified RING finger, HC subclass (C3HC3D-type), found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cd19773
      Location:156 → 205
      Bbox2_TRIM23_C-IX_rpt1; first B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cd19774
      Location:207 → 256
      Bbox2_TRIM23_C-IX_rpt2; second B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl38936
      Location:424 → 510
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030731.3: Suppressed sequence

      Description
      NM_030731.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGX0.1 GenPept UniProtKB/Swiss-Prot:Q8BGX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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