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    Klrb1a killer cell lectin-like receptor subfamily B member 1A [ Mus musculus (house mouse) ]

    Gene ID: 17057, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Klrb1aprovided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily B member 1Aprovided by MGI
    Primary source
    MGI:MGI:107540
    See related
    Ensembl:ENSMUSG00000030361 AllianceGenome:MGI:107540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly55a; NKRP12; Nkrp1a; ly-55A; NKR-P1A; Nkrp1-a; NKR-P1.7
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Located in plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 10.5), mammary gland adult (RPKM 0.9) and 1 other tissue See more
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    Genomic context

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    See Klrb1a in Genome Data Viewer
    Location:
    6 F3; 6 63.06 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128586190..128599897, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128609227..128622934, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 8724 Neighboring gene alpha-2-macroglobulin like 1 Neighboring gene STARR-positive B cell enhancer ABC_E2211 Neighboring gene STARR-positive B cell enhancer mm9_chr6:128563719-128564020 Neighboring gene predicted gene, 44478 Neighboring gene target of myb1 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure. Rozbeský D, et al. Proteins, 2016 Sep. PMID 27238500
    2. Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 Å resolution. Kolenko P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Dec 1. PMID 22139156, Free PMC Article
    3. Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. Li Y, et al. Proc Natl Acad Sci U S A, 2013 Jul 9. PMID 23803857, Free PMC Article
    4. Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells. Adámková L, et al. Int J Mol Sci, 2019 Apr 16. PMID 30995786, Free PMC Article
    5. Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons. Pereira RA, et al. J Immunol, 2001 May 15. PMID 11342599

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface.
      Title: Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
    2. Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure.
      Title: Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure.
    3. structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 A resolution from a merohedrally twinned crystal
      Title: Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 Å resolution.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily B member 1A
    Names
    CD161 antigen-like family member A
    NKR-P1 2
    lymphocyte antigen 55 complex, locus A
    lymphocyte antigen 55A
    natural killer cell receptor protein NKR-P1A
    natural killer cell receptor-P1
    natural killer cell surface protein P1-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159902.1 → NP_001153374.1  killer cell lectin-like receptor subfamily B member 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC132352, BC120707, BC145045, M77676, M77753
      Consensus CDS
      CCDS51918.1
      UniProtKB/TrEMBL
      B7ZN67, E9Q0W1
      Related
      ENSMUSP00000132390.3, ENSMUST00000171306.5
      Conserved Domains (1) summary
      cd03593
      Location:67 → 185
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. NM_010737.3 → NP_034867.3  killer cell lectin-like receptor subfamily B member 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132352, BC120707, M77676, M77753
      Consensus CDS
      CCDS20574.2
      UniProtKB/TrEMBL
      A0A1U9W180, G5E882
      Related
      ENSMUSP00000032512.9, ENSMUST00000032512.15
      Conserved Domains (2) summary
      cd03593
      Location:100 → 218
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:47 → 221
      PHA03097; C-type lectin-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128586190..128599897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27811.2 GenPept UniProtKB/Swiss-Prot:P27811

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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