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    Ddx24 DEAD box helicase 24 [ Mus musculus (house mouse) ]

    Gene ID: 27225, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ddx24provided by MGI
    Official Full Name
    DEAD box helicase 24provided by MGI
    Primary source
    MGI:MGI:1351337
    See related
    Ensembl:ENSMUSG00000041645 AllianceGenome:MGI:1351337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700055J08Rik; 2510027P10Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be active in nucleolus. Orthologous to human DDX24 (DEAD-box helicase 24). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 38.5), cortex adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx24 in Genome Data Viewer
    Location:
    12 E; 12 52.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103374235..103392106, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103407976..103425847, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene OTU domain, ubiquitin aldehyde binding 2 Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability. Gan H, et al. Int Immunopharmacol, 2024 Mar 10. PMID 38354508
    2. DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling. Ma Z, et al. PLoS Pathog, 2013 Oct. PMID 24204270, Free PMC Article
    3. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. Zhao Y, et al. Genomics, 2000 Aug 1. PMID 10936056
    4. DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App(N-LF) Mice and Influences Presymptomatic Pathology. Axenhus M, et al. Int J Mol Sci, 2024 Mar 23. PMID 38612434, Free PMC Article
    5. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App[N-LF] Mice and Influences Presymptomatic Pathology.
      Title: DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App(N-LF) Mice and Influences Presymptomatic Pathology.
    2. Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability.
      Title: Endothelium-targeted Ddx24 conditional knockout exacerbates ConA-induced hepatitis in mice due to vascular hyper-permeability.
    3. data provide a new function for DDX24 and help explain innate immune gene regulation, mechanisms that may additionally provide insight into the causes of inflammatory disease.
      Title: DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    DEAD box protein 24
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A)
    NP_001152974.1
    NP_001351091.1
    NP_001351092.1
    NP_065240.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159502.2 → NP_001152974.1  ATP-dependent RNA helicase DDX24 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154347, BB006411, BC055317
      Consensus CDS
      CCDS49152.1
      UniProtKB/TrEMBL
      F8WJA0, Q3U7R4
      Related
      ENSMUSP00000105628.3, ENSMUST00000110001.4
      Conserved Domains (3) summary
      COG0513
      Location:238 → 787
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:619 → 727
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:241 → 557
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001364162.1 → NP_001351091.1  ATP-dependent RNA helicase DDX24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154347
      Consensus CDS
      CCDS26129.1
      UniProtKB/Swiss-Prot
      Q61119, Q7TM97, Q9ESV0
      UniProtKB/TrEMBL
      Q3U7R4
      Conserved Domains (1) summary
      COG0513
      Location:192 → 741
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    3. NM_001364163.1 → NP_001351092.1  ATP-dependent RNA helicase DDX24 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154347
      Consensus CDS
      CCDS26129.1
      UniProtKB/Swiss-Prot
      Q61119, Q7TM97, Q9ESV0
      UniProtKB/TrEMBL
      Q3U7R4
      Conserved Domains (1) summary
      COG0513
      Location:192 → 741
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    4. NM_020494.4 → NP_065240.2  ATP-dependent RNA helicase DDX24 isoform 2

      See identical proteins and their annotated locations for NP_065240.2

      Status: VALIDATED

      Source sequence(s)
      BB006411, BC043721, CJ141277
      Consensus CDS
      CCDS26129.1
      UniProtKB/Swiss-Prot
      Q61119, Q7TM97, Q9ESV0
      UniProtKB/TrEMBL
      Q3U7R4
      Related
      ENSMUSP00000040890.8, ENSMUST00000044923.15
      Conserved Domains (1) summary
      COG0513
      Location:192 → 741
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103374235..103392106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESV0.2 GenPept UniProtKB/Swiss-Prot:Q9ESV0

    Gene LinkOut

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