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    Ifi27l2a interferon, alpha-inducible protein 27 like 2A [ Mus musculus (house mouse) ]

    Gene ID: 76933, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ifi27l2aprovided by MGI
    Official Full Name
    interferon, alpha-inducible protein 27 like 2Aprovided by MGI
    Primary source
    MGI:MGI:1924183
    See related
    Ensembl:ENSMUSG00000079017 AllianceGenome:MGI:1924183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ifi27; Isg12; Isg12(b1); 2310061N23Rik
    Summary
    Predicted to enable identical protein binding activity and molecular adaptor activity. Acts upstream of or within response to virus. Predicted to be located in nuclear envelope. Predicted to be active in mitochondrial membrane. Is expressed in embryo. Orthologous to several human genes including IFI27L2 (interferon alpha inducible protein 27 like 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 553.4), subcutaneous fat pad adult (RPKM 344.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ifi27l2a in Genome Data Viewer
    Location:
    12 E; 12 52.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103400132..103409939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103433873..103443680, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner. Lucas TM, et al. J Virol, 2015 Dec 23. PMID 26699642, Free PMC Article
    2. The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection. Tantawy MA, et al. PLoS One, 2014. PMID 25184786, Free PMC Article
    3. Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells. Li B, et al. Endocrinology, 2009 Mar. PMID 18948406
    4. Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue. Ohgaki S, et al. J Atheroscler Thromb, 2007 Aug. PMID 17704618
    5. Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12. Labrada L, et al. J Virol, 2002 Nov. PMID 12388728, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, these findings suggest that Ifi27l2a has an antiviral phenotype in subsets of cells and that at least some interferon-stimulated genes have specific inhibitory functions in restricted tissues in West Nile virus infection.
      Title: The Interferon-Stimulated Gene Ifi27l2a Restricts West Nile Virus Infection and Pathogenesis in a Cell-Type- and Region-Specific Manner.
    2. up-regulation of Ifi27l2a in infected lungs is mainly due to the infiltration of macrophages and lymphocytes. Most surprisingly, deletion of Ifi27l2a in mouse knock-out lines did not result in increased susceptibility to infections
      Title: The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.
    3. modulator of innate immune responses in sepsis models
      Title: ISG12 is a critical modulator of innate immune responses in murine models of sepsis.
    4. Identify a feedback loop activated by interferons via interferon stimulated gene 12 that inhibits the vasculoprotective functions of NR4A1 nuclear receptors.
      Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.
    5. Mitochondrial-localized ISG12b1 protein inhibits adipocyte differentiation and mitochondrial biogenesis and function.
      Title: Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells.
    6. ISG12b is an additional candidate for a adipocytokine induced to express in adipose tissue by interferon
      Title: Identification of ISG12b as a putative interferon-inducible adipocytokine which is highly expressed in white adipose tissue.
    7. induced by Sindbis virus encephalitis to greater levels in brains of weanling mice than neonatal mice and significantly delayed death in the neonatal mice (interferon- inducible protective protein, ISG12).
      Title: Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interferon alpha-inducible protein 27-like protein 2A
    Names
    interferon stimulated gene 12(b1)
    interferon-stimulated gene 12 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281830.1 → NP_001268759.1  interferon alpha-inducible protein 27-like protein 2A isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154347, AK040279
      Conserved Domains (1) summary
      pfam06140
      Location:12 → 67
      Ifi-6-16; Interferon-induced 6-16 family

    2. NM_029803.3 → NP_084079.1  interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_084079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154347, AK160503
      Consensus CDS
      CCDS49153.1
      UniProtKB/Swiss-Prot
      Q8R412
      Related
      ENSMUSP00000054698.9, ENSMUST00000055071.9
      Conserved Domains (1) summary
      pfam06140
      Location:12 → 76
      Ifi-6-16; Interferon-induced 6-16 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103400132..103409939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157657.1 → XP_036013550.1  interferon alpha-inducible protein 27-like protein 2A isoform X1

      Conserved Domains (1) summary
      pfam06140
      Location:3 → 66
      Ifi-6-16; Interferon-induced 6-16 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R412.1 GenPept UniProtKB/Swiss-Prot:Q8R412

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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