Trim30d tripartite motif-containing 30D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim30dprovided by MGI
Official Full Name: tripartite motif-containing 30Dprovided by MGI
Primary source: MGI:MGI:3035181
See related: Ensembl:ENSMUSG00000057596 AllianceGenome:MGI:3035181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trim79; TRIM30-3
Summary: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Predicted to be located in P-body. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with omegasome. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in bladder adult (RPKM 2.7), large intestine adult (RPKM 2.5) and 23 other tissues See more
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Genomic context

Location:: 7 E3; 7 55.69 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (104119221..104157062, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (104470014..104507853, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM79 restricts tick-borne encephalitis virus replication by degradation the NS5 protein, an RNA-dependent RNA polymerase essential for virus replication.
Title: TRIM79α, an interferon-stimulated gene product, restricts tick-borne encephalitis virus replication by degrading the viral RNA polymerase.

Submit: New GeneRIF Correction

General gene information

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Markers

AI451617 (e-PCR)
- UniSTS:208171

UniSTS:234144 (e-PCR)
- UniSTS:234144

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with omegasome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing 79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167828.1 → NP_001161300.1 tripartite motif-containing 79 isoform 2

See identical proteins and their annotated locations for NP_001161300.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon from the 5' coding region, compared to variant 1. This difference results in the use of an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AK136456, BX525206

Consensus CDS

CCDS52347.1

UniProtKB/TrEMBL

Q3TNW3

Related

ENSMUSP00000065020.7, ENSMUST00000071069.13

Conserved Domains (1) summary

cd15822
Location:140 → 343

SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)
NM_199146.2 → NP_954597.2 tripartite motif-containing 79 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC122400, AK136456, BX525206

Consensus CDS

CCDS40069.1

UniProtKB/TrEMBL

E9PWL0, Q6PHA8

Related

ENSMUSP00000033211.8, ENSMUST00000033211.14

Conserved Domains (3) summary

smart00336
Location:91 → 132

BBOX; B-Box-type zinc finger

cd00162
Location:14 → 61

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15822
Location:290 → 493

SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

104119221..104157062 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507548.4 → XP_006507611.1 tripartite motif-containing 79 isoform X2

See identical proteins and their annotated locations for XP_006507611.1

Conserved Domains (2) summary

cd16591
Location:12 → 60

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cl00034
Location:96 → 133

Bbox_SF; B-box-type zinc finger superfamily
XM_006507546.4 → XP_006507609.1 tripartite motif-containing 79 isoform X1

See identical proteins and their annotated locations for XP_006507609.1

Conserved Domains (2) summary

cd16591
Location:12 → 60

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cl00034
Location:96 → 133

Bbox_SF; B-box-type zinc finger superfamily
XM_006507549.5 → XP_006507612.1 tripartite motif-containing 79 isoform X2

See identical proteins and their annotated locations for XP_006507612.1

Conserved Domains (2) summary

cd16591
Location:12 → 60

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cl00034
Location:96 → 133

Bbox_SF; B-box-type zinc finger superfamily
XM_006507547.5 → XP_006507610.1 tripartite motif-containing 79 isoform X1

See identical proteins and their annotated locations for XP_006507610.1

Conserved Domains (2) summary

cd16591
Location:12 → 60

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cl00034
Location:96 → 133

Bbox_SF; B-box-type zinc finger superfamily