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    Cbx2 chromobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 12416, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cbx2provided by MGI
    Official Full Name
    chromobox 2provided by MGI
    Primary source
    MGI:MGI:88289
    See related
    Ensembl:ENSMUSG00000025577 AllianceGenome:MGI:88289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pc; M33; MOD2
    Summary
    This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cbx2 in Genome Data Viewer
    Location:
    11 E2; 11 83.33 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118913845..118922101)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119023019..119031275)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35710 Neighboring gene STARR-positive B cell enhancer ABC_E10734 Neighboring gene STARR-seq mESC enhancer starr_31311 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 Neighboring gene predicted gene, 35829 Neighboring gene STARR-positive B cell enhancer ABC_E92 Neighboring gene chromobox 8 Neighboring gene predicted gene, 53657

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Zhen CY, et al. Mol Biol Cell, 2014 Nov 15. PMID 25232004, Free PMC Article
    2. Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice. Han M, et al. Neurosci Lett, 2023 Aug 24. PMID 37422020
    3. Identification of a nuclear localization signal in mouse polycomb protein, M33. Hirose S, et al. Zoolog Sci, 2006 Sep. PMID 17043400
    4. Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter. Sun D, et al. Protein Cell, 2019 Apr. PMID 30357595, Free PMC Article
    5. Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones. Katoh-Fukui Y, et al. Bone, 2019 Mar. PMID 30389610

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice.
      Title: Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice.
    2. CBX2 in DSD: The Quirky Kid on the Block.
      Title: CBX2 in DSD: The Quirky Kid on the Block.
    3. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
      Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
    4. Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model.
      Title: Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model.
    5. CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/beta-catenin pathway.
      Title: CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway.
    6. Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
      Title: Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
    7. This work identifies Cbx2 as a positive mediator in antiviral immunity, which provides new mechanistic insight into epigenetic modifiers in the innate immune response.
      Title: Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter.
    8. Cbx2 controls the maintenance and adipogenic differentiation of mesenchymal stromal cells in the bone marrow.
      Title: Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.
    9. The results suggest that stabilization of the testis fate requires CBX2-mediated repression of bivalent ovary-determining genes, which would otherwise block testis development.
      Title: CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.
    10. Point mutations in an internal domain of Cbx2 eliminate phase separation and eliminate the formation of puncta in cells
      Title: Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in development of primary sexual characteristics IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in development of primary sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PRC1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromobox protein homolog 2
    Names
    M33 polycomb-like protein
    chromobox homolog 2
    modifier 3 protein
    polycomb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007623.3 → NP_031649.2  chromobox protein homolog 2

      See identical proteins and their annotated locations for NP_031649.2

      Status: REVIEWED

      Source sequence(s)
      AK141647, BE986063, CJ176395, X62537
      Consensus CDS
      CCDS25708.1
      UniProtKB/Swiss-Prot
      A2ABG2, O35731, P30658, Q8CIA0
      UniProtKB/TrEMBL
      Q3TZG6
      Related
      ENSMUSP00000026662.8, ENSMUST00000026662.8
      Conserved Domains (1) summary
      pfam00385
      Location:15 → 61
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      118913845..118922101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532104.1 → XP_006532167.1  chromobox protein homolog 2 isoform X2

      UniProtKB/TrEMBL
      Q3TZG6
      Conserved Domains (2) summary
      cd18647
      Location:9 → 61
      CD_Cbx2; chromodomain of chromobox homolog 2
      pfam17218
      Location:539 → 571
      CBX7_C; CBX family C-terminal motif

    2. XM_006532103.1 → XP_006532166.1  chromobox protein homolog 2 isoform X1

      Conserved Domains (1) summary
      pfam17218
      Location:553 → 585
      CBX7_C; CBX family C-terminal motif

    3. XM_006532105.1 → XP_006532168.1  chromobox protein homolog 2 isoform X3

      Conserved Domains (1) summary
      pfam17218
      Location:492 → 524
      CBX7_C; CBX family C-terminal motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30658.2 GenPept UniProtKB/Swiss-Prot:P30658

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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