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    Ddx10 DEAD box helicase 10 [ Mus musculus (house mouse) ]

    Gene ID: 77591, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ddx10provided by MGI
    Official Full Name
    DEAD box helicase 10provided by MGI
    Primary source
    MGI:MGI:1924841
    See related
    Ensembl:ENSMUSG00000053289 AllianceGenome:MGI:1924841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632415A01Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Acts upstream of or within anterior head development. Predicted to be active in nucleus. Orthologous to human DDX10 (DEAD-box helicase 10). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 4.2), liver E14 (RPKM 2.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx10 in Genome Data Viewer
    Location:
    9 A5.3; 9 29.12 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53009754..53159423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53098454..53248170, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1715 Neighboring gene STARR-seq mESC enhancer starr_24139 Neighboring gene predicted gene, 53523 Neighboring gene predicted gene, 39339 Neighboring gene STARR-positive B cell enhancer ABC_E1786 Neighboring gene STARR-seq mESC enhancer starr_24140 Neighboring gene STARR-seq mESC enhancer starr_24141 Neighboring gene exophilin 5 Neighboring gene protein O-glucosyltransferase 3 Neighboring gene microRNA 130c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Palmer K, et al. Dev Biol, 2016 Jul 15. PMID 26234751, Free PMC Article
    2. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Spontaneous (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91294

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX10
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
    DEAD box protein 10
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
    NP_084212.2
    XP_006510747.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029936.2 → NP_084212.2  probable ATP-dependent RNA helicase DDX10

      See identical proteins and their annotated locations for NP_084212.2

      Status: VALIDATED

      Source sequence(s)
      AC112956, AC160139
      Consensus CDS
      CCDS52796.1
      UniProtKB/Swiss-Prot
      Q80Y44
      UniProtKB/TrEMBL
      Q66JW6
      Related
      ENSMUSP00000065198.7, ENSMUST00000065630.8
      Conserved Domains (4) summary
      PRK04837
      Location:69 → 450
      PRK04837; ATP-dependent RNA helicase RhlB; Provisional
      cd00079
      Location:288 → 418
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:71 → 275
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:451 → 510
      DUF4217; Domain of unknown function (DUF4217)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      53009754..53159423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510684.5 → XP_006510747.1  probable ATP-dependent RNA helicase DDX10 isoform X1

      UniProtKB/TrEMBL
      Q8BRE3
      Conserved Domains (2) summary
      PRK01297
      Location:13 → 413
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cd17941
      Location:80 → 277
      DEADc_DDX10; DEAD-box helicase domain of DEAD box protein 10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80Y44.2 GenPept UniProtKB/Swiss-Prot:Q80Y44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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