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    Peak1 pseudopodium-enriched atypical kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 244895, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Peak1provided by MGI
    Official Full Name
    pseudopodium-enriched atypical kinase 1provided by MGI
    Primary source
    MGI:MGI:2442366
    See related
    Ensembl:ENSMUSG00000074305 AllianceGenome:MGI:2442366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGK269; mKIAA2002; 9530046P14; 1110049L02Rik; C230081A13Rik
    Summary
    Predicted to enable identical protein binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including focal adhesion assembly; regulation of focal adhesion assembly; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and focal adhesion. Orthologous to human PEAK1 (pseudopodium enriched atypical kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.8), cerebellum adult (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Peak1 in Genome Data Viewer
    Location:
    9 B; 9 30.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56108410..56325972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56201126..56418222, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55937639-55937826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55938770-55938923 Neighboring gene STARR-positive B cell enhancer ABC_E10547 Neighboring gene STARR-seq mESC enhancer starr_24202 Neighboring gene proline-serine-threonine phosphatase-interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene tetraspanin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_24203 Neighboring gene STARR-seq mESC enhancer starr_24204 Neighboring gene STARR-positive B cell enhancer ABC_E1385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266337-56266490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266643-56266962 Neighboring gene high mobility group 20A Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56313127-56313350 Neighboring gene ubiquitin-conjugating enzyme E2S, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_24205 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56354440-56354627 Neighboring gene predicted gene, 53524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Wang H, et al. Cell Discov, 2018. PMID 29872538, Free PMC Article
    2. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Wang Y, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534451, Free PMC Article
    3. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
    4. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
    5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase PEAK1
    Names
    NKF3 kinase family member
    sugen kinase 269
    tyrosine-protein kinase SgK269
    NP_766512.2
    XP_006511230.1
    XP_006511231.1
    XP_036010901.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172924.3 → NP_766512.2  inactive tyrosine-protein kinase PEAK1

      See identical proteins and their annotated locations for NP_766512.2

      Status: VALIDATED

      Source sequence(s)
      AC160935, AK004211, AK035440, AK048912, AK173328, AW457766, CJ186507
      Consensus CDS
      CCDS52804.1
      UniProtKB/Swiss-Prot
      E9QKY2, Q69Z38, Q8BX56, Q8R365
      Related
      ENSMUSP00000109901.3, ENSMUST00000061552.15
      Conserved Domains (2) summary
      pfam05109
      Location:475 → 853
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1492 → 1657
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56108410..56325972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155008.1 → XP_036010901.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      UniProtKB/Swiss-Prot
      E9QKY2, Q69Z38, Q8BX56, Q8R365
      Conserved Domains (2) summary
      pfam05109
      Location:475 → 853
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1492 → 1657
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006511168.5 → XP_006511231.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_006511231.1

      UniProtKB/Swiss-Prot
      E9QKY2, Q69Z38, Q8BX56, Q8R365
      Conserved Domains (2) summary
      pfam05109
      Location:475 → 853
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1492 → 1657
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006511167.5 → XP_006511230.1  inactive tyrosine-protein kinase PEAK1 isoform X1

      See identical proteins and their annotated locations for XP_006511230.1

      UniProtKB/Swiss-Prot
      E9QKY2, Q69Z38, Q8BX56, Q8R365
      Conserved Domains (2) summary
      pfam05109
      Location:475 → 853
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl21453
      Location:1492 → 1657
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69Z38.4 GenPept UniProtKB/Swiss-Prot:Q69Z38

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