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    Dpysl3 dihydropyrimidinase-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 22240, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dpysl3provided by MGI
    Official Full Name
    dihydropyrimidinase-like 3provided by MGI
    Primary source
    MGI:MGI:1349762
    See related
    Ensembl:ENSMUSG00000024501 AllianceGenome:MGI:1349762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TUC4; Ulip; DRP-3; Ulip1; CRMP-4; ULIP-1
    Summary
    This gene encodes a protein that belongs to the TUC (TOAD-64/Ulip/CRMP) family of proteins. Members of this family are phosphoproteins that function in axonal guidance and neuronal differentiation during development and regeneration of the nervous system. A mutation in the human gene is associated with amyotrophic lateral sclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in CNS E18 (RPKM 272.7), whole brain E14.5 (RPKM 195.1) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpysl3 in Genome Data Viewer
    Location:
    18; 18 B3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (43454044..43571354, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (43320979..43438286, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44447 Neighboring gene predicted gene 8181 Neighboring gene STARR-seq mESC enhancer starr_44448 Neighboring gene STARR-seq mESC enhancer starr_44449 Neighboring gene serine/threonine kinase 32A Neighboring gene STARR-seq mESC enhancer starr_44450 Neighboring gene predicted gene, 31647 Neighboring gene STARR-seq mESC enhancer starr_44451 Neighboring gene predicted gene, 41714 Neighboring gene predicted gene 3650 Neighboring gene eukaryotic translation initiation factor 3, subunit J2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product. Byk T, et al. J Neurosci, 1996 Jan 15. PMID 8551352, Free PMC Article
    2. Postnatal alteration of collapsin response mediator protein 4 mRNA expression in the mouse brain. Tsutiya A, et al. J Anat, 2012 Oct. PMID 22816653, Free PMC Article
    3. Developmental exposure to manganese chloride induces sustained aberration of neurogenesis in the hippocampal dentate gyrus of mice. Wang L, et al. Toxicol Sci, 2012 Jun. PMID 22407947
    4. The role of CRMP4 in LPS-induced neuroinflammation. Asahina R, et al. Brain Res, 2024 Oct 15. PMID 38914219
    5. Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. Khazaei MR, et al. J Biol Chem, 2014 Oct 24. PMID 25225289, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of CRMP4 in LPS-induced neuroinflammation.
      Title: The role of CRMP4 in LPS-induced neuroinflammation.
    2. CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice.
      Title: CRMP4 Up-regulates M2 Macrophages and Myeloid-derived Suppressor Cells to Promote Pancreatic Cancer in Mice.
    3. CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
      Title: CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
    4. A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
      Title: A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
    5. Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
      Title: Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury.
    6. Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
      Title: Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson's Disease.
    7. Results found that Crmp4-KO mice have abnormalities that are relevant to some phenotypes of human autism spectrum disorders (ASD). Accumulating evidence suggests that a disturbance in the regulatory function of CRMP4 in forming neuronal networks is an important aspect underlying some characteristics of ASD, including sexual differences. These findings provide CRMP4 as a novel candidate gene contributing to ASD.
      Title: Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
    8. Knockdown of DPYSL3 promoted the metastatic ability of Lewis lung carcinoma cells.
      Title: Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer.
    9. findings identify CRMP4 as a novel negative regulator of osteoblast differentiation.
      Title: CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling.
    10. Crmp4 deletion promotes axonal growth and nociceptive recovery after spinal cord injury.
      Title: Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chondroitin sulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables dihydropyrimidinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin crosslink formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin crosslink formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to cytokine stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in pyrimidine nucleobase catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to axon injury ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with exocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of filamentous actin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dihydropyrimidinase-related protein 3
    Names
    collapsin response mediator protein 4
    unc-33-like phosphoprotein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136086.2 → NP_001129558.1  dihydropyrimidinase-related protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001129558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than CRMP4b.
      Source sequence(s)
      AC101718, AK133040, BQ175584
      Consensus CDS
      CCDS50269.1
      UniProtKB/TrEMBL
      Q3TT92
      Related
      ENSMUSP00000113711.2, ENSMUST00000118043.8
      Conserved Domains (2) summary
      PRK09060
      Location:15 → 465
      PRK09060; dihydroorotase; Validated
      TIGR02033
      Location:15 → 469
      D-hydantoinase; D-hydantoinase

    2. NM_001291455.2 → NP_001278384.1  dihydropyrimidinase-related protein 3 isoform CRMP4b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (CRMP4b, also known as isoform 3).
      Source sequence(s)
      AC101718
      Consensus CDS
      CCDS79639.1
      UniProtKB/TrEMBL
      E9PWE8
      Related
      ENSMUSP00000112928.2, ENSMUST00000121805.9
      Conserved Domains (2) summary
      PRK09060
      Location:130 → 580
      PRK09060; dihydroorotase; Validated
      TIGR02033
      Location:130 → 584
      D-hydantoinase; D-hydantoinase

    3. NM_009468.6 → NP_033494.1  dihydropyrimidinase-related protein 3 isoform CRMP4a

      See identical proteins and their annotated locations for NP_033494.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from an alternate start codon compared to variant 3. The encoded isoform (CRMP4a, also known as isoform 2) has a distinct N-terminus and is shorter than CRMP4b.
      Source sequence(s)
      AC101718
      Consensus CDS
      CCDS37801.1
      UniProtKB/Swiss-Prot
      Q62188
      Related
      ENSMUSP00000025379.8, ENSMUST00000025379.14
      Conserved Domains (2) summary
      PRK09060
      Location:17 → 467
      PRK09060; dihydroorotase; Validated
      TIGR02033
      Location:17 → 471
      D-hydantoinase; D-hydantoinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      43454044..43571354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62188.1 GenPept UniProtKB/Swiss-Prot:Q62188

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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