Mlana melan-A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mlanaprovided by MGI
Official Full Name: melan-Aprovided by MGI
Primary source: MGI:MGI:108454
See related: Ensembl:ENSMUSG00000024806 AllianceGenome:MGI:108454
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mart1; A930034P04Rik
Summary: Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum membrane; melanosome; and trans-Golgi network. Is expressed in dermis; eye; and pigmented retinal epithelium. Orthologous to human MLANA (melan-A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 1.4), lung adult (RPKM 0.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 24.28 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (29674956..29685847)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (29697541..29708447)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell passaging severely reduced the expression of genes encoding markers typical of UM, including those of the prognostic gene signature. Marked differences between gene expression profiles of primary tumors and cell lines could be linked to the infiltrating immune and stromal cells in situ.
Title: Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors.
MART-1 is a pigmentation gene that is required for melanosome biogenesis and/or maintenance.
Title: Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.
Results suggest that the MART-1::Cre line may serve as a novel and useful tool for functional studies in melanocytes and retinal pigment epithelium.
Title: A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium.
OA1 interacts with MART-1 at early stages of melanogenesis to control melanosome identity and composition.
Title: The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.
mLANA and p53 have roles in virus replication
Title: ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490524

NoName (e-PCR)
- UniSTS:493018

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanoma antigen recognized by T-cells 1

Names: melanoma associated antigen recognized by T-cells 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.