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    Cep89 centrosomal protein 89 [ Mus musculus (house mouse) ]

    Gene ID: 72140, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cep89provided by MGI
    Official Full Name
    centrosomal protein 89provided by MGI
    Primary source
    MGI:MGI:1919390
    See related
    Ensembl:ENSMUSG00000023072 AllianceGenome:MGI:1919390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc123; 2610507L03Rik
    Summary
    Predicted to be involved in cilium assembly and mitochondrion organization. Located in centriole and motile cilium. Part of ciliary transition fiber. Is expressed in cerebral cortex. Orthologous to human CEP89 (centrosomal protein 89). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.4), CNS E11.5 (RPKM 8.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep89 in Genome Data Viewer
    Location:
    7 B2; 7 21.37 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35096425..35139255)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35396999..35439830)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene predicted gene, 51476 Neighboring gene STARR-positive B cell enhancer ABC_E699 Neighboring gene Fanconi anemia core complex associated protein 24 Neighboring gene predicted gene, 42378 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Primary ciliogenesis requires the distal appendage component Cep123. Sillibourne JE, et al. Biol Open, 2013 Jun 15. PMID 23789104, Free PMC Article
    2. Centrosome anchoring regulates progenitor properties and cortical formation. Shao W, et al. Nature, 2020 Apr. PMID 32238932, Free PMC Article
    3. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Ye X, et al. Proc Natl Acad Sci U S A, 2014 Feb 11. PMID 24469809, Free PMC Article
    4. Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. Ding W, et al. J Neurosci, 2019 Mar 13. PMID 30626697, Free PMC Article
    5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ciliary transition fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ciliary transition fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 89 kDa
    Names
    coiled-coil domain containing 123
    coiled-coil domain-containing protein 123, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028120.3 → NP_082396.1  centrosomal protein of 89 kDa

      See identical proteins and their annotated locations for NP_082396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding variant.
      Source sequence(s)
      AC151535, AK012067, AK029107
      Consensus CDS
      CCDS39911.1
      UniProtKB/Swiss-Prot
      Q8C127, Q9CZX2
      Related
      ENSMUSP00000078383.6, ENSMUST00000079414.12
      Conserved Domains (1) summary
      cl15415
      Location:458 → 540
      Sec1; Sec1 family

    RNA

    1. NR_153799.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC151535, AC154126

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      35096425..35139255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153454.1 → XP_036009347.1  centrosomal protein of 89 kDa isoform X1

      Conserved Domains (1) summary
      COG1196
      Location:7 → 243
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_004934188.1 RNA Sequence

    2. XR_004934187.1 RNA Sequence

    3. XR_004934189.1 RNA Sequence

      Related
      ENSMUST00000141704.8

    4. XR_391104.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZX2.1 GenPept UniProtKB/Swiss-Prot:Q9CZX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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