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    UTS2 urotensin 2 [ Homo sapiens (human) ]

    Gene ID: 10911, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UTS2provided by HGNC
    Official Full Name
    urotensin 2provided by HGNC
    Primary source
    HGNC:HGNC:12636
    See related
    Ensembl:ENSG00000049247 MIM:604097; AllianceGenome:HGNC:12636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UII; U-II; UCN2; PRO1068
    Summary
    This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See UTS2 in Genome Data Viewer
    Location:
    1p36.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7847612..7913249, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7378659..7444444, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (7907672..7913551, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene vesicle associated membrane protein 3 Neighboring gene period circadian regulator 3 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7912645-7913333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7929285-7930484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7935645-7936144 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7970949-7971450 Neighboring gene tRNA-undetermined (NNN) 4-1 Neighboring gene TNF receptor superfamily member 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 93 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:8020839-8021622 and GRCh37_chr1:8021623-8022406 Neighboring gene Parkinsonism associated deglycase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Relationship between coronary in-stent restenosis and plasma urotensin II level. Yavuz F, et al. Minerva Cardioangiol, 2014 Jun. PMID 24831766
    2. [Expression and role of urotensin II on the lung of patients with pulmonary hypertension with congenital heart disease]. Rong X, et al. Zhonghua Er Ke Za Zhi, 2012 Sep. PMID 23158820
    3. Serum urotensin II levels in patients with non-dipper hypertension. Erbay AR, et al. Clin Exp Hypertens, 2013. PMID 23301552
    4. Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD). Oztuzcu S, et al. Peptides, 2013 Apr. PMID 23333481
    5. The role of urotensin II in cardiovascular and renal physiology and diseases. Zhu YC, et al. Br J Pharmacol, 2006 Aug. PMID 16783414, Free PMC Article

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
      Title: Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors.
    2. Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea.
      Title: Serum Urotensin II Levels Are Elevated in Patients with Obstructive Sleep Apnea.
    3. Urotensin II level is elevated in inflammatory bowel disease patients.
      Title: Urotensin II level is elevated in inflammatory bowel disease patients.
    4. Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behcet's Disease.
      Title: Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behçet's Disease.
    5. Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability.
      Title: Dynamic Changes in Plasma Urotensin II and Its Correlation With Plaque Stability.
    6. Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia.
      Title: Expression of urotensin II is positively correlated with pyroptosis-related molecules in patients with severe preeclampsia.
    7. Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.
      Title: Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population.
    8. Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
      Title: Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients.
    9. positive correlation with autophagic marker LC3II in placentas of preeclampsia patients
      Title: Expression of urotensin II is associated with placental autophagy in patients with severe preeclampsia.
    10. Study findings suggest that UT-2 has a high potential as a vasoconstrictor agent in human bodies and its level increases through a bolus or continuous infusion of 5-fluorouracil (5-FU). Increased UT-2 levels are likely to play a role in 5-FU-related cardiac toxicity pathogenesis.
      Title: Role of Urotensin-2 in 5-Fluorouracil-Related Arterial Vasoconstriction in Cancer Patients.
    Submit: New GeneRIF Correction See all GeneRIFs (92)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    urotensin-2
    Names
    prepro U-II
    urotensin II

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006786.4 → NP_006777.1  urotensin-2 isoform b preproprotein

      See identical proteins and their annotated locations for NP_006777.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes a shorter preproprotein isoform (b) of 124 amino acids with a different amino-terminal end compared to isoform a. The mature peptide is identical for both transcript variants.
      Source sequence(s)
      AF104118, AY358375, Z98884
      Consensus CDS
      CCDS91.1
      UniProtKB/Swiss-Prot
      O95399, Q5H8X7, Q6UXF6, Q9UKP7
      UniProtKB/TrEMBL
      Q5H8X8
      Related
      ENSP00000355163.5, ENST00000361696.10
      Conserved Domains (1) summary
      pfam02083
      Location:113 → 124
      Urotensin_II; Urotensin II

    2. NM_021995.2 → NP_068835.1  urotensin-2 isoform a preproprotein

      See identical proteins and their annotated locations for NP_068835.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a longer preproprotein isoform (a) of 139 amino acids with a different amino-terminal end compared to isoform b. The mature peptide is identical for both transcript variants.
      Source sequence(s)
      AF140630, AY358375, BC126443
      Consensus CDS
      CCDS90.1
      UniProtKB/Swiss-Prot
      O95399
      UniProtKB/TrEMBL
      A0AVP6
      Related
      ENSP00000054668.5, ENST00000054668.5
      Conserved Domains (1) summary
      pfam02083
      Location:128 → 139
      Urotensin_II; Urotensin II

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      7847612..7913249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540537.3 → XP_011538839.1  urotensin-2 isoform X1

      See identical proteins and their annotated locations for XP_011538839.1

      UniProtKB/Swiss-Prot
      O95399
      Conserved Domains (1) summary
      pfam02083
      Location:128 → 139
      Urotensin_II; Urotensin II

    2. XM_011540538.2 → XP_011538840.1  urotensin-2 isoform X2

      See identical proteins and their annotated locations for XP_011538840.1

      UniProtKB/Swiss-Prot
      O95399, Q5H8X7, Q6UXF6, Q9UKP7
      UniProtKB/TrEMBL
      Q5H8X8
      Conserved Domains (1) summary
      pfam02083
      Location:113 → 124
      Urotensin_II; Urotensin II

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      7378659..7444444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333954.1 → XP_054189929.1  urotensin-2 isoform X1

    2. XM_054333955.1 → XP_054189930.1  urotensin-2 isoform X2

      UniProtKB/TrEMBL
      Q5H8X8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95399.1 GenPept UniProtKB/Swiss-Prot:O95399

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