UCA1 urothelial cancer associated 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: UCA1provided by HGNC
Official Full Name: urothelial cancer associated 1provided by HGNC
Primary source: HGNC:HGNC:37126
See related: Ensembl:ENSG00000214049 MIM:617500; AllianceGenome:HGNC:37126
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CUDR; UCAT1; LINC00178; NCRNA00178; onco-lncRNA-36
Summary: This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha. [provided by RefSeq, Dec 2017]
Expression: Biased expression in gall bladder (RPKM 19.1), endometrium (RPKM 12.1) and 5 other tissues See more
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Genomic context

Location:: 19p13.12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (15828947..15836321)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (15957070..15964444)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (15939757..15947131)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UCA1 Inhibits NKG2D-mediated Cytotoxicity of NK Cells to Breast Cancer.
Title: UCA1 Inhibits NKG2D-mediated Cytotoxicity of NK Cells to Breast Cancer.
[High expression of long noncoding RNA UCA1 promotes invasion, migration and epithelial-mesenchymal transition of trophoblasts in vitro].
Title: [High expression of long noncoding RNA UCA1 promotes invasion, migration and epithelial-mesenchymal transition of trophoblasts in vitro].
LncRNA urothelial cancer associated 1 promotes the osteogenic differentiation of human periodontal ligament stem cells by regulating the miR-96-5p/Osx axis.
Title: LncRNA urothelial cancer associated 1 promotes the osteogenic differentiation of human periodontal ligament stem cells by regulating the miR-96-5p/Osx axis.
Dysregulation of Serum UCA1 and Its Clinical Significance in Patients with Acute Cerebral Infarction.
Title: Dysregulation of Serum UCA1 and Its Clinical Significance in Patients with Acute Cerebral Infarction.
LncRNA UCA1 promotes pancreatic cancer cell migration by regulating mitochondrial dynamics via the MAPK pathway.
Title: LncRNA UCA1 promotes pancreatic cancer cell migration by regulating mitochondrial dynamics via the MAPK pathway.
Long Noncoding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation.
Title: Long Noncoding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation.
Over-expression of Long Non-coding RNA Urothelial Cancer-associated 1 as a Predictive Marker for Prostate Cancer.
Title: Over-expression of Long Non-coding RNA Urothelial Cancer-associated 1 as a Predictive Marker for Prostate Cancer.
Clinical Value and Mechanism of Long Non-Coding RNA UCA1 in Acute Respiratory Distress Syndrome Induced by Cardiopulmonary Bypass.
Title: Clinical Value and Mechanism of Long Non-Coding RNA UCA1 in Acute Respiratory Distress Syndrome Induced by Cardiopulmonary Bypass.
LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1alpha/NF-kappaB axis in psoriasis.
Title: LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1α/NF-κB axis in psoriasis.
Long non-coding RNA UCA1 regulates MPP[+]-induced neuronal damage through the miR-671-5p/KPNA4 pathway in SK-N-SH cells.
Title: Long non-coding RNA UCA1 regulates MPP(+)-induced neuronal damage through the miR-671-5p/KPNA4 pathway in SK-N-SH cells.

Submit: New GeneRIF Correction See all GeneRIFs (223)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH101962 (e-PCR)
- UniSTS:96297

G42921 (e-PCR)
- UniSTS:94822

A009A18 (e-PCR)
- UniSTS:27281

SHGC-56644 (e-PCR)
- UniSTS:34204

Other Names

cancer up-regulated drug resistant
long intergenic non-protein coding RNA 178
urothelial cancer associated 1 (non-protein coding)

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.