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    TMEM218 transmembrane protein 218 [ Homo sapiens (human) ]

    Gene ID: 219854, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM218provided by HGNC
    Official Full Name
    transmembrane protein 218provided by HGNC
    Primary source
    HGNC:HGNC:27344
    See related
    Ensembl:ENSG00000150433 MIM:619285; AllianceGenome:HGNC:27344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JBTS39
    Summary
    Predicted to be located in cilium and membrane. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 5.9), adrenal (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM218 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (125094389..125111626, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (125123053..125140287, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124964285..124981522, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:124823758-124824301 Neighboring gene coiled-coil domain containing 15 Neighboring gene MPRA-validated peak1499 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124853252-124854004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5693 Neighboring gene solute carrier family 37 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124951446-124951995 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124952423-124953622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:124981662-124982574 Neighboring gene keratin 18 pseudogene 59 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:125011687-125012243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4039 Neighboring gene PKNOX2 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. TMEM218 dysfunction causes ciliopathies, including Joubert and Meckel syndromes. Van De Weghe JC, et al. HGG Adv, 2021 Jan 14. PMID 33791682, Free PMC Article
    2. The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies. Epting D, et al. Hum Mol Genet, 2022 Jul 21. PMID 35137054
    3. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. Li C, et al. PLoS Biol, 2016 Mar. PMID 26982032, Free PMC Article
    4. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
    5. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Joubert syndrome 39
    MedGen: C5562000 OMIM: 619562 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp667A247

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 218

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080546.3 → NP_001074015.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001074015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BC144277, BX094574, CX870447, DB194956
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000279968.4, ENST00000279968.8

    2. NM_001258238.2 → NP_001245167.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001245167.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA781367, AP001007, BC132716, BI829527, BX094574, CX870447
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    3. NM_001258239.3 → NP_001245168.2  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    4. NM_001258240.2 → NP_001245169.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001245169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA781367, AP001007, BC132716, BM042315, BM928068, BX094574, CX870447, DA774499
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000436177.1, ENST00000526175.5

    5. NM_001258241.2 → NP_001245170.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001245170.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA781367, AP001007, BC132716, BM042315, BX094574, CX870447, DA774499
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000436162.1, ENST00000527271.5

    6. NM_001258242.3 → NP_001245171.2  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000436596.1, ENST00000531909.5

    7. NM_001258243.3 → NP_001245172.2  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 2. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000434597.1, ENST00000532407.5

    8. NM_001258244.2 → NP_001245173.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001245173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BE513148, BQ681518, BX094574, CX870447
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000506979.1, ENST00000682305.1

    9. NM_001258245.2 → NP_001245174.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001245174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BQ223298, BU855096, BX094574, CX870447
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000433374.1, ENST00000529583.5

    10. NM_001258246.3 → NP_001245175.2  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    11. NM_001258247.2 → NP_001245176.1  transmembrane protein 218 isoform 2

      See identical proteins and their annotated locations for NP_001245176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BI856825, BX094574, CX870447
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48
      Related
      ENSP00000435526.1, ENST00000527766.5

    12. NM_001387230.1 → NP_001374159.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    13. NM_001387231.1 → NP_001374160.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    14. NM_001387232.1 → NP_001374161.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    15. NM_001387233.1 → NP_001374162.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    16. NM_001387234.1 → NP_001374163.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    17. NM_001387235.1 → NP_001374164.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    18. NM_001387236.1 → NP_001374165.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    19. NM_001387237.1 → NP_001374166.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    20. NM_001387238.1 → NP_001374167.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    21. NM_001387239.1 → NP_001374168.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    22. NM_001387240.1 → NP_001374169.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    23. NM_001387241.1 → NP_001374170.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    24. NM_001387242.1 → NP_001374171.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    25. NM_001387244.1 → NP_001374173.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (33) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    26. NM_001387245.1 → NP_001374174.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (34) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    27. NM_001387246.1 → NP_001374175.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (35) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    28. NM_001387247.1 → NP_001374176.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (36) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    29. NM_001387248.1 → NP_001374177.1  transmembrane protein 218 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (37) differs in the 5' UTR compared to variant 1. Variants 1-11 and 19-37 all encode the same isoform (2).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS31715.1
      UniProtKB/Swiss-Prot
      A2RU14, B7ZM48

    30. NM_001387249.1 → NP_001374178.1  transmembrane protein 218 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (38) encodes the longest isoform (3).
      Source sequence(s)
      AP001007
      Consensus CDS
      CCDS91617.1
      UniProtKB/TrEMBL
      E9PI23
      Related
      ENSP00000436578.1, ENST00000528724.5

    31. NM_001387250.1 → NP_001374179.1  transmembrane protein 218 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (39), as well as variants 40-43, encodes isoform 4.
      Source sequence(s)
      AP001007

    32. NM_001387251.1 → NP_001374180.1  transmembrane protein 218 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (40), as well as variants 39 and 41-43, encodes isoform 4.
      Source sequence(s)
      AP001007

    33. NM_001387252.1 → NP_001374181.1  transmembrane protein 218 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (41), as well as variants 39, 40, 42, and 43, encodes isoform 4.
      Source sequence(s)
      AP001007

    34. NM_001387253.1 → NP_001374182.1  transmembrane protein 218 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (42), as well as variants 39-41 and 43, encodes isoform 4.
      Source sequence(s)
      AP001007

    35. NM_001387254.1 → NP_001374183.1  transmembrane protein 218 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (43), as well as variants 39-42, encodes isoform 4.
      Source sequence(s)
      AP001007

    36. NM_001387255.1 → NP_001374184.1  transmembrane protein 218 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (44), as well as variants 45-48, encodes isoform 5.
      Source sequence(s)
      AP001007

    37. NM_001387256.1 → NP_001374185.1  transmembrane protein 218 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (45), as well as variants 44 and 46-48, encodes isoform 5.
      Source sequence(s)
      AP001007

    38. NM_001387257.1 → NP_001374186.1  transmembrane protein 218 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (46), as well as variants 44, 45, 47, and 48, encodes isoform 5.
      Source sequence(s)
      AP001007

    39. NM_001387258.1 → NP_001374187.1  transmembrane protein 218 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (47), as well as variants 44-46 and 48, encodes isoform 5.
      Source sequence(s)
      AP001007

    40. NM_001387259.1 → NP_001374188.1  transmembrane protein 218 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (48), as well as variants 44-47, encodes isoform 5.
      Source sequence(s)
      AP001007

    RNA

    1. NR_047586.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA781367, AP001007, BC132716, BI192743, BX094574, CX870447

    2. NR_047587.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) lacks several alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA781367, AP001007, BC132716, BE974033, BX094574, CX870447, DA774499

    3. NR_047588.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BC144276, BX094574, CX870447, DB194956

    4. NR_047589.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA459752, AA781367, AP001007, BQ225039, BX094574, CX870447

    5. NR_047590.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BU598207, BX094574, CX870447

    6. NR_047591.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BI547955, BX094574, CX870447

    7. NR_047592.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA459752, AA781367, AP001007, BC132716, BU160644, BU598207, BX094574, CX870447

    8. NR_170600.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    9. NR_170601.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    10. NR_170602.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    11. NR_170603.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    12. NR_170604.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    13. NR_170605.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    14. NR_170606.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    15. NR_170607.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    16. NR_170608.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    17. NR_170609.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    18. NR_170610.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    19. NR_170611.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    20. NR_170612.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    21. NR_170613.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001007

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      125094389..125111626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426541.1 → XP_047282497.1  transmembrane protein 218 isoform X1

    2. XM_047426543.1 → XP_047282499.1  transmembrane protein 218 isoform X1

    3. XM_047426540.1 → XP_047282496.1  transmembrane protein 218 isoform X1

    4. XM_047426542.1 → XP_047282498.1  transmembrane protein 218 isoform X1

    5. XM_006718780.4 → XP_006718843.1  transmembrane protein 218 isoform X1

      See identical proteins and their annotated locations for XP_006718843.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      125123053..125140287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367985.1 → XP_054223960.1  transmembrane protein 218 isoform X1

    2. XM_054367987.1 → XP_054223962.1  transmembrane protein 218 isoform X1

    3. XM_054367986.1 → XP_054223961.1  transmembrane protein 218 isoform X1

    4. XM_054367988.1 → XP_054223963.1  transmembrane protein 218 isoform X1

    5. XM_054367984.1 → XP_054223959.1  transmembrane protein 218 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RU14.1 GenPept UniProtKB/Swiss-Prot:A2RU14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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