PPIAL4A peptidylprolyl isomerase A like 4A [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPIAL4Aprovided by HGNC
Official Full Name: peptidylprolyl isomerase A like 4Aprovided by HGNC
Primary source: HGNC:HGNC:24369
See related: Ensembl:ENSG00000263353 AllianceGenome:HGNC:24369
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: COAS2; COAS-2; PPIAL4; PPIAL4B
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1p11.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (120889771..120890530)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (120899147..120899906)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (144363462..144364221, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CyPA mediates the ox-LDL-induced activation and apoptosis in RAW264.7 cells by regulating autophagy.
Title: Cyclophilin A mediates the ox-LDL-induced activation and apoptosis of macrophages via autophagy.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC262691P6 (e-PCR)
- UniSTS:272328

NoName (e-PCR)
- UniSTS:483537

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase A-like 4A

Names: PPIase A-like 4B; PPIase A-like 4G; chromosome 1-amplified sequence 2; chromosome one-amplified sequence 2; cyclophilin homolog overexpressed in liver cancer; cyclophilin-LC (COAS2); peptidyl-prolyl cis-trans isomerase A-like 4A/B/C; peptidylprolyl cis-trans isomerase A-like 4B; peptidylprolyl isomerase A (cyclophilin A)-like 4A; peptidylprolyl isomerase A (cyclophilin A)-like 4B

NP_001137355.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143883.4 → NP_001137355.1 peptidyl-prolyl cis-trans isomerase A-like 4A

See identical proteins and their annotated locations for NP_001137355.1

Status: VALIDATED

Source sequence(s)

AC253572

Consensus CDS

CCDS76197.1

UniProtKB/Swiss-Prot

Q9Y536

UniProtKB/TrEMBL

A0A0H2UH34

Related

ENSP00000485206.1, ENST00000577856.3

Conserved Domains (1) summary

cl00197
Location:4 → 162

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...