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    SHC1 SHC adaptor protein 1 [ Homo sapiens (human) ]

    Gene ID: 6464, updated on 3-Nov-2024

    Summary

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    Official Symbol
    SHC1provided by HGNC
    Official Full Name
    SHC adaptor protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10840
    See related
    Ensembl:ENSG00000160691 MIM:600560; AllianceGenome:HGNC:10840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SHC; SHCA
    Summary
    This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in fat (RPKM 25.3), gall bladder (RPKM 24.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SHC1 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154962298..154974376, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154101659..154113737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154934774..154946852, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154917055-154917556 Neighboring gene PBX homeobox interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154924461-154924960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154931761-154932260 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:154933865-154934605 and GRCh37_chr1:154934606-154935345 Neighboring gene pygopus family PHD finger 2 Neighboring gene PYGO2 and SHC1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942000-154942550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942551-154943101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1800 Neighboring gene microRNA 4258 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154953875-154954472 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154955073-154955670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154958088-154958777 Neighboring gene flavin adenine dinucleotide synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy. Xu X, et al. Sci Rep, 2016 Jul 5. PMID 27377870, Free PMC Article
    2. A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria. Ventura A, et al. J Biol Chem, 2004 Jan 16. PMID 14573619
    3. p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. Grossman SR, et al. Clin Cancer Res, 2007 Oct 1. PMID 17908971
    4. A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells. Jücker M, et al. Blood, 1997 Mar 15. PMID 9058724
    5. Recombinant adenovirus of human p66Shc inhibits MCF-7 cell proliferation. Yang X, et al. Sci Rep, 2016 Aug 17. PMID 27530145, Free PMC Article

    See all (580) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
      Title: CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
    2. The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma.
      Title: The mitochondria-related gene risk mode revealed p66Shc as a prognostic mitochondria-related gene of glioblastoma.
    3. MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis.
      Title: MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis.
    4. YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
      Title: YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.
    5. Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
      Title: Mitochondrial Translocation of P66Shc Aggravates Cisplatin-induced AKI by Promoting Ferroptosis.
    6. Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in promoting advanced prostate cancer progression.
      Title: Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in promoting advanced prostate cancer progression.
    7. The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic beta-Cells Under Lipotoxic Conditions.
      Title: The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions.
    8. The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma.
      Title: The E3 ubiquitin ligase SOCS-7 reverses immunosuppression via Shc1 signaling in hepatocellular carcinoma.
    9. Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways.
      Title: Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways.
    10. The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.
      Title: The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.
    Submit: New GeneRIF Correction See all GeneRIFs (173)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed
    tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
    nucleocapsid gag SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26504

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables epidermal growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables insulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin-like growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neurotrophin TRKA receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell proliferation in bone marrow IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of superoxide metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Shc-EGFR complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    SHC-transforming protein 1
    Names
    SH2 domain protein C1
    SHC (Src homology 2 domain containing) transforming protein 1
    SHC-transforming protein 3
    SHC-transforming protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029028.1 RefSeqGene

      Range
      8737..17186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130040.2 → NP_001123512.1  SHC-transforming protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001123512.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      BX647149
      Consensus CDS
      CCDS44233.1
      UniProtKB/TrEMBL
      B4DL02
      Related
      ENSP00000401303.3, ENST00000448116.7
      Conserved Domains (2) summary
      cd09925
      Location:481 → 584
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    2. NM_001130041.2 → NP_001123513.1  SHC-transforming protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001123513.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (4), also known as p52Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3.
      Source sequence(s)
      AK292143, BC014158, X68148
      Consensus CDS
      CCDS44234.1
      UniProtKB/TrEMBL
      B4DL02
      Related
      ENSP00000357435.1, ENST00000368450.5
      Conserved Domains (2) summary
      cd09925
      Location:370 → 473
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36 → 207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    3. NM_001202859.2 → NP_001189788.1  SHC-transforming protein 1 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (5), also known as p46Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3. Variants 4 and 5 have the same nucleotide sequence, but variant 5 represents use of a downstream AUG compared to variant 4.
      Source sequence(s)
      AK292143, BC014158
      UniProtKB/TrEMBL
      X6R6D0
      Related
      ENSP00000357434.4, ENST00000368449.8
      Conserved Domains (2) summary
      cd09925
      Location:325 → 428
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:1 → 162
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    4. NM_003029.5 → NP_003020.2  SHC-transforming protein 1 isoform 2

      See identical proteins and their annotated locations for NP_003020.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.
      Source sequence(s)
      AK292143, BC014158
      Consensus CDS
      CCDS1076.1
      UniProtKB/TrEMBL
      B4DL02
      Related
      ENSP00000357438.4, ENST00000368453.8
      Conserved Domains (2) summary
      cd09925
      Location:371 → 474
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36 → 207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    5. NM_183001.5 → NP_892113.4  SHC-transforming protein 1 isoform 1

      See identical proteins and their annotated locations for NP_892113.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (1), also known as p66Shc, lacks an internal amino acid, as compared to isoform 3.
      Source sequence(s)
      BX647149
      Consensus CDS
      CCDS30881.1
      UniProtKB/Swiss-Prot
      B5BU19, D3DV78, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1
      UniProtKB/TrEMBL
      B4DL02
      Related
      ENSP00000357430.5, ENST00000368445.9
      Conserved Domains (2) summary
      cd09925
      Location:480 → 583
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      154962298..154974376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002083.2 → XP_016857572.1  SHC-transforming protein 1 isoform X20

      UniProtKB/TrEMBL
      B4DL02

    2. XM_047427986.1 → XP_047283942.1  SHC-transforming protein 1 isoform X19

    3. XM_011509897.2 → XP_011508199.1  SHC-transforming protein 1 isoform X18

      UniProtKB/TrEMBL
      B4DL02
      Conserved Domains (2) summary
      cd09925
      Location:362 → 465
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36 → 189
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    4. XM_047427994.1 → XP_047283950.1  SHC-transforming protein 1 isoform X22

    5. XM_047427991.1 → XP_047283947.1  SHC-transforming protein 1 isoform X21

    6. XM_047427972.1 → XP_047283928.1  SHC-transforming protein 1 isoform X15

    7. XM_047427970.1 → XP_047283926.1  SHC-transforming protein 1 isoform X14

    8. XM_047427989.1 → XP_047283945.1  SHC-transforming protein 1 isoform X20

    9. XM_047427988.1 → XP_047283944.1  SHC-transforming protein 1 isoform X19

    10. XM_047427995.1 → XP_047283951.1  SHC-transforming protein 1 isoform X22

    11. XM_047427982.1 → XP_047283938.1  SHC-transforming protein 1 isoform X17

    12. XM_047427992.1 → XP_047283948.1  SHC-transforming protein 1 isoform X21

    13. XM_047427974.1 → XP_047283930.1  SHC-transforming protein 1 isoform X16

    14. XM_047427973.1 → XP_047283929.1  SHC-transforming protein 1 isoform X15

    15. XM_047427971.1 → XP_047283927.1  SHC-transforming protein 1 isoform X14

    16. XM_047427959.1 → XP_047283915.1  SHC-transforming protein 1 isoform X7

    17. XM_047427958.1 → XP_047283914.1  SHC-transforming protein 1 isoform X4

      UniProtKB/Swiss-Prot
      B5BU19, D3DV78, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1

    18. XM_047427984.1 → XP_047283940.1  SHC-transforming protein 1 isoform X17

    19. XM_047427993.1 → XP_047283949.1  SHC-transforming protein 1 isoform X21

    20. XM_047427978.1 → XP_047283934.1  SHC-transforming protein 1 isoform X16

    21. XM_047427983.1 → XP_047283939.1  SHC-transforming protein 1 isoform X17

    22. XM_047427975.1 → XP_047283931.1  SHC-transforming protein 1 isoform X16

    23. XM_047427964.1 → XP_047283920.1  SHC-transforming protein 1 isoform X12

    24. XM_017002081.3 → XP_016857570.1  SHC-transforming protein 1 isoform X6

      UniProtKB/TrEMBL
      B4DL02

    25. XM_011509894.4 → XP_011508196.1  SHC-transforming protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DL02
      Conserved Domains (2) summary
      cd09925
      Location:472 → 575
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 299
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    26. XM_047427963.1 → XP_047283919.1  SHC-transforming protein 1 isoform X11

    27. XM_047427962.1 → XP_047283918.1  SHC-transforming protein 1 isoform X10

    28. XM_047427961.1 → XP_047283917.1  SHC-transforming protein 1 isoform X9

    29. XM_011509893.4 → XP_011508195.1  SHC-transforming protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DL02
      Conserved Domains (2) summary
      cd09925
      Location:489 → 592
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    30. XM_047427960.1 → XP_047283916.1  SHC-transforming protein 1 isoform X8

    31. XM_011509892.4 → XP_011508194.1  SHC-transforming protein 1 isoform X2

      UniProtKB/TrEMBL
      B4DL02
      Conserved Domains (2) summary
      cd09925
      Location:490 → 593
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    32. XM_005245449.6 → XP_005245506.1  SHC-transforming protein 1 isoform X1

      Conserved Domains (2) summary
      cd09925
      Location:480 → 583
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146 → 317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    33. XM_011509898.3 → XP_011508200.1  SHC-transforming protein 1 isoform X23

      UniProtKB/TrEMBL
      Q59HB0
      Conserved Domains (2) summary
      cd09925
      Location:314 → 417
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:1 → 151
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    34. XM_005245451.5 → XP_005245508.1  SHC-transforming protein 1 isoform X13

      See identical proteins and their annotated locations for XP_005245508.1

      UniProtKB/TrEMBL
      B4DL02
      Conserved Domains (2) summary
      cd09925
      Location:370 → 473
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36 → 207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    35. XM_047427967.1 → XP_047283923.1  SHC-transforming protein 1 isoform X13

    36. XM_047427969.1 → XP_047283925.1  SHC-transforming protein 1 isoform X13

    37. XM_047427968.1 → XP_047283924.1  SHC-transforming protein 1 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154101659..154113737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338246.1 → XP_054194221.1  SHC-transforming protein 1 isoform X20

    2. XM_054338244.1 → XP_054194219.1  SHC-transforming protein 1 isoform X19

    3. XM_054338243.1 → XP_054194218.1  SHC-transforming protein 1 isoform X18

    4. XM_054338251.1 → XP_054194226.1  SHC-transforming protein 1 isoform X22

    5. XM_054338248.1 → XP_054194223.1  SHC-transforming protein 1 isoform X21

    6. XM_054338235.1 → XP_054194210.1  SHC-transforming protein 1 isoform X15

    7. XM_054338233.1 → XP_054194208.1  SHC-transforming protein 1 isoform X14

    8. XM_054338247.1 → XP_054194222.1  SHC-transforming protein 1 isoform X20

    9. XM_054338245.1 → XP_054194220.1  SHC-transforming protein 1 isoform X19

    10. XM_054338252.1 → XP_054194227.1  SHC-transforming protein 1 isoform X22

    11. XM_054338240.1 → XP_054194215.1  SHC-transforming protein 1 isoform X17

    12. XM_054338249.1 → XP_054194224.1  SHC-transforming protein 1 isoform X21

    13. XM_054338237.1 → XP_054194212.1  SHC-transforming protein 1 isoform X16

    14. XM_054338236.1 → XP_054194211.1  SHC-transforming protein 1 isoform X15

    15. XM_054338234.1 → XP_054194209.1  SHC-transforming protein 1 isoform X14

    16. XM_054338223.1 → XP_054194198.1  SHC-transforming protein 1 isoform X7

    17. XM_054338220.1 → XP_054194195.1  SHC-transforming protein 1 isoform X4

      UniProtKB/Swiss-Prot
      B5BU19, D3DV78, O15290, P29353, Q5T180, Q5T183, Q5T184, Q5T185, Q5T186, Q8N4K5, Q96CL1

    18. XM_054338242.1 → XP_054194217.1  SHC-transforming protein 1 isoform X17

    19. XM_054338250.1 → XP_054194225.1  SHC-transforming protein 1 isoform X21

    20. XM_054338239.1 → XP_054194214.1  SHC-transforming protein 1 isoform X16

    21. XM_054338241.1 → XP_054194216.1  SHC-transforming protein 1 isoform X17

    22. XM_054338238.1 → XP_054194213.1  SHC-transforming protein 1 isoform X16

    23. XM_054338228.1 → XP_054194203.1  SHC-transforming protein 1 isoform X12

    24. XM_054338222.1 → XP_054194197.1  SHC-transforming protein 1 isoform X6

    25. XM_054338221.1 → XP_054194196.1  SHC-transforming protein 1 isoform X5

    26. XM_054338227.1 → XP_054194202.1  SHC-transforming protein 1 isoform X11

    27. XM_054338226.1 → XP_054194201.1  SHC-transforming protein 1 isoform X10

    28. XM_054338225.1 → XP_054194200.1  SHC-transforming protein 1 isoform X9

    29. XM_054338219.1 → XP_054194194.1  SHC-transforming protein 1 isoform X3

    30. XM_054338224.1 → XP_054194199.1  SHC-transforming protein 1 isoform X8

    31. XM_054338218.1 → XP_054194193.1  SHC-transforming protein 1 isoform X2

    32. XM_054338217.1 → XP_054194192.1  SHC-transforming protein 1 isoform X1

    33. XM_054338253.1 → XP_054194228.1  SHC-transforming protein 1 isoform X23

    34. XM_054338229.1 → XP_054194204.1  SHC-transforming protein 1 isoform X13

    35. XM_054338230.1 → XP_054194205.1  SHC-transforming protein 1 isoform X13

    36. XM_054338232.1 → XP_054194207.1  SHC-transforming protein 1 isoform X13

    37. XM_054338231.1 → XP_054194206.1  SHC-transforming protein 1 isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29353.4 GenPept UniProtKB/Swiss-Prot:P29353

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