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    PAQR7 progestin and adipoQ receptor family member 7 [ Homo sapiens (human) ]

    Gene ID: 164091, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PAQR7provided by HGNC
    Official Full Name
    progestin and adipoQ receptor family member 7provided by HGNC
    Primary source
    HGNC:HGNC:23146
    See related
    Ensembl:ENSG00000182749 MIM:607779; AllianceGenome:HGNC:23146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mSR; MPRA; PGLP
    Summary
    Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney (RPKM 22.0), testis (RPKM 21.9) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAQR7 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25861484..25875708, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25698915..25713139, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26187975..26202199, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 467 Neighboring gene uncharacterized LOC646471 Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene hESC enhancers GRCh37_chr1:26185603-26186228 and GRCh37_chr1:26186229-26186854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26189139-26189908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26196207-26196708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26201379-26201878 Neighboring gene stathmin 1 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRα regulating its trafficking to the cell surface. Thomas P, et al. Steroids, 2023 Nov. PMID 37558174
    2. Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. Thomas P, et al. Steroids, 2009 Jul. PMID 19071147
    3. Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells. Pang Y, et al. J Mol Endocrinol, 2019 Oct. PMID 31416049
    4. Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs). Jyoti MMS, et al. Biochem Biophys Res Commun, 2022 Feb 12. PMID 35007844
    5. Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells. Castelnovo LF, et al. J Mol Neurosci, 2022 Oct. PMID 35974286

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
      Title: Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
    2. Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRalpha regulating its trafficking to the cell surface.
      Title: Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRα regulating its trafficking to the cell surface.
    3. Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor alpha (mPRalpha/PAQR7).
      Title: Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7).
    4. Membrane Progesterone Receptor alpha (mPRalpha/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells.
      Title: Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells.
    5. Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs).
      Title: Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs).
    6. Membrane progesterone receptor alpha (mPRalpha/PAQR7) promotes migration, proliferation and BDNF release in human Schwann cell-like differentiated adipose stem cells.
      Title: Membrane progesterone receptor α (mPRα/PAQR7) promotes migration, proliferation and BDNF release in human Schwann cell-like differentiated adipose stem cells.
    7. The results suggest that progesterone induces vascular smooth muscle cell relaxation by reducing cellular calcium levels through mPRalpha-induced alterations in multiple signaling pathways.
      Title: Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells.
    8. Utilizing both genetic and pharmacologic approaches, the authors establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7).
      Title: Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors.
    9. The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229.
      Title: Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma Spheroids In Vitro.
    10. Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines.
      Title: Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear steroid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables steroid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to steroid hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor alpha
    Names
    2310021M12Rik
    mPR alpha
    membrane progesterone P4 receptor alpha
    membrane progesterone receptor alpha
    progesterone and adipoQ receptor family member 7
    progestin and adipoQ receptor family member VII

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178422.6 → NP_848509.1  membrane progestin receptor alpha

      See identical proteins and their annotated locations for NP_848509.1

      Status: VALIDATED

      Source sequence(s)
      AL033528
      Consensus CDS
      CCDS267.1
      UniProtKB/Swiss-Prot
      A2A2D3, Q5XKF9, Q86VE4, Q86WK9
      Related
      ENSP00000502514.1, ENST00000675840.1
      Conserved Domains (1) summary
      pfam03006
      Location:66 → 290
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      25861484..25875708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245746.4 → XP_005245803.1  membrane progestin receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_005245803.1

      UniProtKB/Swiss-Prot
      A2A2D3, Q5XKF9, Q86VE4, Q86WK9
      Conserved Domains (1) summary
      pfam03006
      Location:66 → 290
      HlyIII; Haemolysin-III related

    2. XM_011540862.3 → XP_011539164.1  membrane progestin receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_011539164.1

      UniProtKB/Swiss-Prot
      A2A2D3, Q5XKF9, Q86VE4, Q86WK9
      Conserved Domains (1) summary
      pfam03006
      Location:66 → 290
      HlyIII; Haemolysin-III related

    3. XM_047447964.1 → XP_047303920.1  membrane progestin receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      A2A2D3, Q5XKF9, Q86VE4, Q86WK9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25698915..25713139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334782.1 → XP_054190757.1  membrane progestin receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      A2A2D3, Q5XKF9, Q86VE4, Q86WK9

    2. XM_054334783.1 → XP_054190758.1  membrane progestin receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      A2A2D3, Q5XKF9, Q86VE4, Q86WK9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86WK9.1 GenPept UniProtKB/Swiss-Prot:Q86WK9

    Gene LinkOut

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