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    ZNF391 zinc finger protein 391 [ Homo sapiens (human) ]

    Gene ID: 346157, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF391provided by HGNC
    Official Full Name
    zinc finger protein 391provided by HGNC
    Primary source
    HGNC:HGNC:18779
    See related
    Ensembl:ENSG00000124613 AllianceGenome:HGNC:18779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ153G14.3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 2.3), thyroid (RPKM 2.1) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF391 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27374615..27403908)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27243773..27273038)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27342394..27371687)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17024 Neighboring gene tRNA-iMet (anticodon CAT) 1-5 Neighboring gene tRNA-Lys (anticodon TTT) 6-1 Neighboring gene zinc finger protein 204, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:27335298-27335798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:27335799-27336299 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:27340678-27340840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24282 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:27346083-27346611 Neighboring gene zinc finger protein 184 Neighboring gene multiple coagulation factor deficiency 2 pseudogene 1 Neighboring gene MPRA-validated peak5742 silencer Neighboring gene MPRA-validated peak5743 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24286 Neighboring gene uncharacterized LOC105375001

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach. Ren H, et al. Schizophr Bull, 2021 Aug 21. PMID 33822213, Free PMC Article
    2. Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins. Review article. Fuchs O, et al. Sb Lek, 2003. PMID 14577126
    3. Singlet oxygen-induced signaling effects in mammalian cells. Klotz LO, et al. Photochem Photobiol Sci, 2003 Feb. PMID 12664966
    4. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Brayer KJ, et al. Cell Biochem Biophys, 2008. PMID 18253864
    5. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Hu Q, et al. Cell Res, 2019 Apr. PMID 30631154, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach.
      Title: Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 391

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076781.3 → NP_001070249.1  zinc finger protein 391

      See identical proteins and their annotated locations for NP_001070249.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AK294965, AL031118, BC035154, BM906507, BX400006, CN294872, DB297905
      Consensus CDS
      CCDS43429.1
      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Related
      ENSP00000244576.4, ENST00000244576.9
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001322288.2 → NP_001309217.1  zinc finger protein 391

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AK294965, AL031118, BC035154, BG722372, BM906507, BX400006, CN294872, DB060105, DB297905
      Consensus CDS
      CCDS43429.1
      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001322289.2 → NP_001309218.1  zinc finger protein 391

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AK294965, AL031118, BC035154, BM906507, BX282552, BX400006, CN294872, DA758693, DB297905
      Consensus CDS
      CCDS43429.1
      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001322293.2 → NP_001309222.1  zinc finger protein 391

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AK294965, AL031118, BC035154, BM906507, BX400006, CN294872, DB297905
      Consensus CDS
      CCDS43429.1
      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      27374615..27403908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715086.3 → XP_006715149.1  zinc finger protein 391 isoform X1

      See identical proteins and their annotated locations for XP_006715149.1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011514569.2 → XP_011512871.1  zinc finger protein 391 isoform X1

      See identical proteins and their annotated locations for XP_011512871.1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005249082.3 → XP_005249139.1  zinc finger protein 391 isoform X1

      See identical proteins and their annotated locations for XP_005249139.1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7
      Conserved Domains (4) summary
      COG5048
      Location:163 → 340
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:333 → 355
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      27243773..27273038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355338.1 → XP_054211313.1  zinc finger protein 391 isoform X1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7

    2. XM_054355336.1 → XP_054211311.1  zinc finger protein 391 isoform X1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7

    3. XM_054355335.1 → XP_054211310.1  zinc finger protein 391 isoform X1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7

    4. XM_054355337.1 → XP_054211312.1  zinc finger protein 391 isoform X1

      UniProtKB/Swiss-Prot
      B4DH77, Q9UJN7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013719.1: Suppressed sequence

      Description
      NM_001013719.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJN7.2 GenPept UniProtKB/Swiss-Prot:Q9UJN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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