Arhgef10 Rho guanine nucleotide exchange factor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgef10provided by MGI
Official Full Name: Rho guanine nucleotide exchange factor 10provided by MGI
Primary source: MGI:MGI:2444453
See related: Ensembl:ENSMUSG00000071176 AllianceGenome:MGI:2444453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0294; 6430549H08Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in lung adult (RPKM 7.6), bladder adult (RPKM 6.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 7.59 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (14956405..15051085)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (14906412..15001085)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Social behavior is impaired in Arhgef10 knockout mice. ARHGEF10 is a candidate risk gene for ASD.
Title: Impairment of social behaviors in Arhgef10 knockout mice.
ARHGEF10 serves as an important regulator of platelet shape change, spreading, and aggregation and plays important role in arterial thrombosis formation.
Title: ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	IEA Inferred from Electronic Annotation more info
involved_in centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	IEA Inferred from Electronic Annotation more info
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 10

Names: Rho guanine nucleotide exchange factor (GEF) 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037736.2 → NP_001032825.1 rho guanine nucleotide exchange factor 10 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes isoform b, which is shorter than isoform a.

Source sequence(s)

AK147669, BC059212, BC066074, CD774578

Consensus CDS

CCDS40241.1

UniProtKB/TrEMBL

Q3UGZ6

Related

ENSMUSP00000106424.3, ENSMUST00000110800.9

Conserved Domains (2) summary

pfam00621
Location:366 → 544

RhoGEF; RhoGEF domain

cl17171
Location:576 → 640

PH-like; Pleckstrin homology-like domain
NM_172751.3 → NP_766339.2 rho guanine nucleotide exchange factor 10 isoform a

See identical proteins and their annotated locations for NP_766339.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

AK147669, BC059212, BC066074, CD774578

Consensus CDS

CCDS40240.1

UniProtKB/Swiss-Prot

Q5DU38, Q80VH8, Q8BW76, Q8C033, Q922S7

UniProtKB/TrEMBL

Q3UGZ6

Related

ENSMUSP00000081225.6, ENSMUST00000084207.12

Conserved Domains (3) summary

cd00160
Location:398 → 582

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:862 → 1343

WD40_2; WD40 repeated domain

pfam19057
Location:605 → 754

PH_19; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

14956405..15051085

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243425.2 → XP_030099285.1 rho guanine nucleotide exchange factor 10 isoform X7

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:398 → 582

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:615 → 679

PH-like; Pleckstrin homology-like domain
XM_017312669.3 → XP_017168158.1 rho guanine nucleotide exchange factor 10 isoform X1

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:482 → 666

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:699 → 763

PH-like; Pleckstrin homology-like domain
XM_036153887.1 → XP_036009780.1 rho guanine nucleotide exchange factor 10 isoform X3

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:482 → 666

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:946 → 1427

WD40_2; WD40 repeated domain

pfam19057
Location:689 → 838

PH_19; PH domain
XM_036153888.1 → XP_036009781.1 rho guanine nucleotide exchange factor 10 isoform X4

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:443 → 627

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:907 → 1427

WD40_2; WD40 repeated domain

pfam19057
Location:650 → 799

PH_19; PH domain
XM_036153889.1 → XP_036009782.1 rho guanine nucleotide exchange factor 10 isoform X6

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:443 → 627

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:907 → 1388

WD40_2; WD40 repeated domain

pfam19057
Location:650 → 799

PH_19; PH domain
XM_036153886.1 → XP_036009779.1 rho guanine nucleotide exchange factor 10 isoform X2

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:481 → 665

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:945 → 1465

WD40_2; WD40 repeated domain

pfam19057
Location:688 → 837

PH_19; PH domain
XM_017312673.2 → XP_017168162.1 rho guanine nucleotide exchange factor 10 isoform X7

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:398 → 582

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:615 → 679

PH-like; Pleckstrin homology-like domain
XM_006508771.5 → XP_006508834.1 rho guanine nucleotide exchange factor 10 isoform X7

See identical proteins and their annotated locations for XP_006508834.1

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:398 → 582

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:615 → 679

PH-like; Pleckstrin homology-like domain
XM_036153891.1 → XP_036009784.1 rho guanine nucleotide exchange factor 10 isoform X10

UniProtKB/Swiss-Prot

Q5DU38, Q80VH8, Q8BW76, Q8C033, Q922S7

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:398 → 582

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:862 → 1343

WD40_2; WD40 repeated domain

pfam19057
Location:605 → 754

PH_19; PH domain
XM_006508770.4 → XP_006508833.1 rho guanine nucleotide exchange factor 10 isoform X7

See identical proteins and their annotated locations for XP_006508833.1

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:398 → 582

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:615 → 679

PH-like; Pleckstrin homology-like domain
XM_030243426.1 → XP_030099286.1 rho guanine nucleotide exchange factor 10 isoform X11

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:359 → 543

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:576 → 640

PH-like; Pleckstrin homology-like domain
XM_006508772.3 → XP_006508835.1 rho guanine nucleotide exchange factor 10 isoform X8

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:397 → 581

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:614 → 678

PH-like; Pleckstrin homology-like domain
XM_036153892.1 → XP_036009785.1 rho guanine nucleotide exchange factor 10 isoform X12

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:397 → 581

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:861 → 1342

WD40_2; WD40 repeated domain

pfam19057
Location:604 → 753

PH_19; PH domain
XM_036153893.1 → XP_036009786.1 rho guanine nucleotide exchange factor 10 isoform X13

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:358 → 542

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:822 → 1342

WD40_2; WD40 repeated domain

pfam19057
Location:565 → 714

PH_19; PH domain
XM_036153894.1 → XP_036009787.1 rho guanine nucleotide exchange factor 10 isoform X15

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:358 → 542

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:822 → 1303

WD40_2; WD40 repeated domain

pfam19057
Location:565 → 714

PH_19; PH domain
XM_006508768.4 → XP_006508831.1 rho guanine nucleotide exchange factor 10 isoform X5

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:422 → 606

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:639 → 703

PH-like; Pleckstrin homology-like domain
XM_017312672.2 → XP_017168161.1 rho guanine nucleotide exchange factor 10 isoform X14

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (2) summary

cd00160
Location:383 → 567

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:600 → 664

PH-like; Pleckstrin homology-like domain
XM_036153890.1 → XP_036009783.1 rho guanine nucleotide exchange factor 10 isoform X9

UniProtKB/TrEMBL

Q3UGZ6

Conserved Domains (3) summary

cd00160
Location:421 → 605

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam19056
Location:885 → 1366

WD40_2; WD40 repeated domain

pfam19057
Location:628 → 777

PH_19; PH domain
XM_006508773.5 → XP_006508836.1 rho guanine nucleotide exchange factor 10 isoform X16