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    Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked [ Mus musculus (house mouse) ]

    Gene ID: 26905, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Eif2s3xprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene X-linkedprovided by MGI
    Primary source
    MGI:MGI:1349431
    See related
    Ensembl:ENSMUSG00000035150 AllianceGenome:MGI:1349431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif-2gx; eIF-2-gamma X
    Summary
    Predicted to enable methionyl-initiator methionine tRNA binding activity and translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Is active in synapse. Is expressed in several structures, including brain; diaphragm; embryo mesenchyme; liver; and skeletal musculature. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 48.5), placenta adult (RPKM 48.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif2s3x in Genome Data Viewer
    Location:
    X C3; X 41.52 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93232315..93256257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94188709..94212651, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 6987 Neighboring gene STARR-seq mESC enhancer starr_47554 Neighboring gene zinc finger protein X-linked Neighboring gene STARR-seq mESC enhancer starr_47555 Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene kelch-like 15 Neighboring gene microRNA 7673 Neighboring gene predicted gene 5400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Xu J, et al. Gene Expr Patterns, 2006 Jan. PMID 16325480
    2. Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Young-Baird SK, et al. Mol Cell, 2020 Feb 20. PMID 31836389, Free PMC Article
    3. Wnt pathway anomalies in developing amygdalae of Turner syndrome-like mice. Raefski AS, et al. J Mol Neurosci, 2007. PMID 17873295
    4. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Ehrmann IE, et al. Hum Mol Genet, 1998 Oct. PMID 9736774
    5. Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome. Sandstedt SA, et al. Genome Res, 2004 Feb. PMID 14762062, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eif2s3x is expressed higher in females than in males in developing and adult brains as well as adult liver
      Title: Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionyl-initiator methionine tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation factor activity, RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2 subunit 3, X-linked
    Names
    eIF2-gamma X
    eukaryotic translation initiation factor 2 subunit gamma, X-linked
    NP_036140.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012010.3 → NP_036140.1  eukaryotic translation initiation factor 2 subunit 3, X-linked

      See identical proteins and their annotated locations for NP_036140.1

      Status: VALIDATED

      Source sequence(s)
      AL646049, AL646092
      Consensus CDS
      CCDS30277.1
      UniProtKB/Swiss-Prot
      Q9Z0N1
      UniProtKB/TrEMBL
      Q3TML6, Q3UIJ2
      Related
      ENSMUSP00000059395.9, ENSMUST00000050328.15
      Conserved Domains (1) summary
      PTZ00327
      Location:13 → 466
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93232315..93256257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0N1.2 GenPept UniProtKB/Swiss-Prot:Q9Z0N1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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