U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 10425, updated on 3-Dec-2024

    Summary

    Official Symbol
    ARIH2provided by HGNC
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:690
    See related
    Ensembl:ENSG00000177479 MIM:605615; AllianceGenome:HGNC:690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARI2; TRIAD1
    Summary
    The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARIH2 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48918842..48986382)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48947848..49014431)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48956275..49023815)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14340 Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14341 Neighboring gene hESC enhancers GRCh37_chr3:48955152-48955902 and GRCh37_chr3:48955903-48956654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48956655-48957405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48959089-48959589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48961592-48962092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48962093-48962593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19846 Neighboring gene ARIH2 opposite strand lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19847 Neighboring gene MPRA-validated peak4646 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:49000975-49001622 Neighboring gene uncharacterized LOC124909376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49026394-49026957 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49026958-49027520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49028085-49028646 Neighboring gene uncharacterized LOC124906235 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49043602-49044590 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49051026-49051863 Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10938, FLJ33921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    RING-type E3 ubiquitin transferase ARIH2
    all-trans retinoic acid inducible RING finger
    ariadne homolog 2
    protein ariadne-2 homolog
    NP_001304262.1
    NP_001304263.1
    NP_001336138.1
    NP_001336139.1
    NP_001336140.1
    NP_001336141.1
    NP_001336142.1
    NP_001336143.1
    NP_001336144.1
    NP_001336145.1
    NP_001336146.1
    NP_001336147.1
    NP_001336148.1
    NP_001336149.1
    NP_001336150.1
    NP_001336151.1
    NP_001336152.1
    NP_001336153.1
    NP_001336154.1
    NP_001336155.1
    NP_001336156.1
    NP_001336157.1
    NP_001336158.1
    NP_001336159.1
    NP_006312.1
    XP_011531570.1
    XP_011531573.1
    XP_016861023.1
    XP_016861024.1
    XP_024309077.1
    XP_024309079.1
    XP_047303221.1
    XP_047303223.1
    XP_047303234.1
    XP_047303239.1
    XP_047303240.1
    XP_054200902.1
    XP_054200903.1
    XP_054200904.1
    XP_054200905.1
    XP_054200906.1
    XP_054200907.1
    XP_054200908.1
    XP_054200909.1
    XP_054200910.1
    XP_054200911.1
    XP_054200912.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317333.2NP_001304262.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630, AK223550, AL110187
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Related
      ENSP00000403222.1, ENST00000449376.5
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain
    2. NM_001317334.2NP_001304263.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 7, encodes isoform b.
      Source sequence(s)
      AC137630, AL110187, BC000422, BG476221, BM928477
      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (3) summary
      smart00647
      Location:66128
      IBR; In Between Ring fingers
      cd16773
      Location:148
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:156188
      IBR; IBR domain, a half RING-finger domain
    3. NM_001349209.2NP_001336138.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 2, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain
    4. NM_001349210.2NP_001336139.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, 4, and 6, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain
    5. NM_001349211.2NP_001336140.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 4, and 5, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain
    6. NM_001349212.2NP_001336141.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (3) summary
      smart00647
      Location:66128
      IBR; In Between Ring fingers
      cd16773
      Location:148
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:156188
      IBR; IBR domain, a half RING-finger domain
    7. NM_001349213.2NP_001336142.1  E3 ubiquitin-protein ligase ARIH2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes the longest isoform (c).
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    8. NM_001349214.2NP_001336143.1  E3 ubiquitin-protein ligase ARIH2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes the longest isoform (c).
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    9. NM_001349215.2NP_001336144.1  E3 ubiquitin-protein ligase ARIH2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform d.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    10. NM_001349216.2NP_001336145.1  E3 ubiquitin-protein ligase ARIH2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes isoform e.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    11. NM_001349217.2NP_001336146.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13, 14, 15, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    12. NM_001349218.2NP_001336147.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12, 14, 15, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    13. NM_001349219.2NP_001336148.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12, 13, 15, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    14. NM_001349220.2NP_001336149.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 12, 13, 14, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    15. NM_001349221.2NP_001336150.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 12, 13, 14, and 15, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226258
      IBR; IBR domain, a half RING-finger domain
    16. NM_001349222.2NP_001336151.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 18, 19, 20, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124186
      IBR; In Between Ring fingers
      cd16773
      Location:53106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214246
      IBR; IBR domain, a half RING-finger domain
    17. NM_001349223.2NP_001336152.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 17, 19, 20, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124186
      IBR; In Between Ring fingers
      cd16773
      Location:53106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214246
      IBR; IBR domain, a half RING-finger domain
    18. NM_001349224.2NP_001336153.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 17, 18, 20, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124186
      IBR; In Between Ring fingers
      cd16773
      Location:53106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214246
      IBR; IBR domain, a half RING-finger domain
    19. NM_001349225.2NP_001336154.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 17, 18, 19, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124186
      IBR; In Between Ring fingers
      cd16773
      Location:53106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214246
      IBR; IBR domain, a half RING-finger domain
    20. NM_001349226.2NP_001336155.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 17, 18, 19, and 20, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124186
      IBR; In Between Ring fingers
      cd16773
      Location:53106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214246
      IBR; IBR domain, a half RING-finger domain
    21. NM_001349227.2NP_001336156.1  E3 ubiquitin-protein ligase ARIH2 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) encodes isoform h.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (1) summary
      smart00647
      Location:2587
      IBR; In Between Ring fingers
    22. NM_001349228.2NP_001336157.1  E3 ubiquitin-protein ligase ARIH2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 24 and 25, encodes isoform i.
      Source sequence(s)
      AC134028
      UniProtKB/TrEMBL
      C9JCL4
    23. NM_001349229.2NP_001336158.1  E3 ubiquitin-protein ligase ARIH2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 23 and 25, encodes isoform i.
      Source sequence(s)
      AC134028
      UniProtKB/TrEMBL
      C9JCL4
    24. NM_001349230.2NP_001336159.1  E3 ubiquitin-protein ligase ARIH2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 23 and 24, encodes isoform i.
      Source sequence(s)
      AC134028
      UniProtKB/TrEMBL
      C9JCL4
      Related
      ENSP00000404838.1, ENST00000449729.5
    25. NM_006321.4NP_006312.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      See identical proteins and their annotated locations for NP_006312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1, 4, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC137630, AL110187, BC000422, BG476221
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Related
      ENSP00000348769.4, ENST00000356401.9
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. NR_146082.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630
    2. NR_146083.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630
    3. NR_146084.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630
    4. NR_146085.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      48918842..48986382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453309.2XP_024309077.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298330
      IBR; IBR domain, a half RING-finger domain
    2. XM_047447278.1XP_047303234.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

      UniProtKB/TrEMBL
      Q53ET9
    3. XM_011533271.2XP_011531573.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      See identical proteins and their annotated locations for XP_011531573.1

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    4. XM_011533268.2XP_011531570.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      See identical proteins and their annotated locations for XP_011531570.1

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:208270
      IBR; In Between Ring fingers
      cd16773
      Location:137190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    5. XM_047447283.1XP_047303239.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

      UniProtKB/TrEMBL
      Q53ET9
    6. XM_017005534.2XP_016861023.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    7. XM_047447284.1XP_047303240.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

      UniProtKB/TrEMBL
      Q53ET9
    8. XM_024453311.2XP_024309079.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (2) summary
      smart00647
      Location:66128
      IBR; In Between Ring fingers
      cd16773
      Location:148
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    9. XM_047447267.1XP_047303223.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/TrEMBL
      Q53ET9
    10. XM_047447265.1XP_047303221.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/TrEMBL
      Q53ET9
    11. XM_017005535.2XP_016861024.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136198
      IBR; In Between Ring fingers
      cd16773
      Location:65118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      48947848..49014431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344930.1XP_054200905.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
    2. XM_054344934.1XP_054200909.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

      UniProtKB/TrEMBL
      Q53ET9
    3. XM_054344933.1XP_054200908.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9
    4. XM_054344928.1XP_054200903.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/TrEMBL
      Q53ET9
    5. XM_054344935.1XP_054200910.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

      UniProtKB/TrEMBL
      Q53ET9
    6. XM_054344931.1XP_054200906.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9
    7. XM_054344936.1XP_054200911.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

      UniProtKB/TrEMBL
      Q53ET9
    8. XM_054344937.1XP_054200912.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

      UniProtKB/TrEMBL
      Q59HA2
    9. XM_054344927.1XP_054200902.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/TrEMBL
      Q53ET9
    10. XM_054344929.1XP_054200904.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      UniProtKB/TrEMBL
      Q53ET9
    11. XM_054344932.1XP_054200907.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9