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    HDHD3 haloacid dehalogenase like hydrolase domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 81932, updated on 27-Nov-2024

    Summary

    Official Symbol
    HDHD3provided by HGNC
    Official Full Name
    haloacid dehalogenase like hydrolase domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:28171
    See related
    Ensembl:ENSG00000119431 AllianceGenome:HGNC:28171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf158; 2810435D12Rik
    Summary
    Predicted to enable hydrolase activity. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum (RPKM 36.7), adrenal (RPKM 34.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HDHD3 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113373416..113376986, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125572225..125575795, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116135696..116139266, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20201 Neighboring gene B-box and SPRY domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116131698-116132198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116132199-116132699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28837 Neighboring gene aminolevulinate dehydratase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116162720-116163300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20204 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:116171753-116172952 Neighboring gene DNA polymerase epsilon 3, accessory subunit Neighboring gene chromosome 9 open reading frame 43

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    haloacid dehalogenase-like hydrolase domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304509.2NP_001291438.1  haloacid dehalogenase-like hydrolase domain-containing protein 3

      See identical proteins and their annotated locations for NP_001291438.1

      Status: VALIDATED

      Source sequence(s)
      AK315401, BC031878, CN281644
      Consensus CDS
      CCDS6793.1
      UniProtKB/Swiss-Prot
      B2RD47, Q9BSH5
      UniProtKB/TrEMBL
      B3KUF6
      Related
      ENSP00000363295.3, ENST00000374180.4
      Conserved Domains (1) summary
      TIGR02252
      Location:8210
      DREG-2; REG-2-like, HAD superfamily (subfamily IA) hydrolase
    2. NM_001304510.2NP_001291439.1  haloacid dehalogenase-like hydrolase domain-containing protein 3

      See identical proteins and their annotated locations for NP_001291439.1

      Status: VALIDATED

      Source sequence(s)
      BC031878, CN281644, DA964284
      Consensus CDS
      CCDS6793.1
      UniProtKB/Swiss-Prot
      B2RD47, Q9BSH5
      UniProtKB/TrEMBL
      B3KUF6
      Conserved Domains (1) summary
      TIGR02252
      Location:8210
      DREG-2; REG-2-like, HAD superfamily (subfamily IA) hydrolase
    3. NM_001304511.2NP_001291440.1  haloacid dehalogenase-like hydrolase domain-containing protein 3

      See identical proteins and their annotated locations for NP_001291440.1

      Status: VALIDATED

      Source sequence(s)
      BC031878, CD515020, CN281644
      Consensus CDS
      CCDS6793.1
      UniProtKB/Swiss-Prot
      B2RD47, Q9BSH5
      UniProtKB/TrEMBL
      B3KUF6
      Conserved Domains (1) summary
      TIGR02252
      Location:8210
      DREG-2; REG-2-like, HAD superfamily (subfamily IA) hydrolase
    4. NM_001371923.1NP_001358852.1  haloacid dehalogenase-like hydrolase domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AL137066
      Consensus CDS
      CCDS6793.1
      UniProtKB/Swiss-Prot
      B2RD47, Q9BSH5
      UniProtKB/TrEMBL
      B3KUF6
      Conserved Domains (1) summary
      TIGR02252
      Location:8210
      DREG-2; REG-2-like, HAD superfamily (subfamily IA) hydrolase
    5. NM_031219.4NP_112496.1  haloacid dehalogenase-like hydrolase domain-containing protein 3

      See identical proteins and their annotated locations for NP_112496.1

      Status: VALIDATED

      Source sequence(s)
      AL137066
      Consensus CDS
      CCDS6793.1
      UniProtKB/Swiss-Prot
      B2RD47, Q9BSH5
      UniProtKB/TrEMBL
      B3KUF6
      Related
      ENSP00000238379.5, ENST00000238379.9
      Conserved Domains (1) summary
      TIGR02252
      Location:8210
      DREG-2; REG-2-like, HAD superfamily (subfamily IA) hydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113373416..113376986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      125572225..125575795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)