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    SAMD4B sterile alpha motif domain containing 4B [ Homo sapiens (human) ]

    Gene ID: 55095, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SAMD4Bprovided by HGNC
    Official Full Name
    sterile alpha motif domain containing 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:25492
    See related
    Ensembl:ENSG00000179134 MIM:619231; AllianceGenome:HGNC:25492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMGB; Smaug2
    Summary
    Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SAMD4B in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39342421..39390764)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42146695..42195044)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39833061..39876340)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39798467-39798968 Neighboring gene leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10596 Neighboring gene glia maturation factor gamma Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10597 Neighboring gene RNA, 7SL, cytoplasmic 566, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:39880404-39880535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14613 Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14614 Neighboring gene mediator complex subunit 29 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14615 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39893943-39894450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39897901-39898538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39898539-39899177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39899178-39899815 Neighboring gene ZFP36 ring finger protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B. Wu C, et al. Mol Med Rep, 2021 Aug. PMID 34109425, Free PMC Article
    2. SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity. Luo N, et al. BMB Rep, 2010 May. PMID 20510020
    3. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. Baez MV, et al. J Biol Chem, 2005 Dec 30. PMID 16221671
    4. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
    5. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. Meek SE, et al. J Biol Chem, 2004 Jul 30. PMID 15161933

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B.
      Title: miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    4. Results suggest that SAMD4B is a widely expressed gene involved in AP-1-, p53-and p21-mediated transcriptional signaling activity.
      Title: SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10211, MGC99832

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Smaug homolog 2
    Names
    SAM domain-containing protein 4B
    smaug 2
    smaug homolog B
    sterile alpha motif domain-containing protein 4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303614.2 → NP_001290543.1  protein Smaug homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001290543.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (b) is shorter, and has a distinct C-terminus, compared to isoform a. Variants 2 and 15-19 all encode the same isoform (b).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS77295.1
      UniProtKB/TrEMBL
      M0QZ22, Q66K25
      Related
      ENSP00000470237.1, ENST00000598913.5
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    2. NM_001384565.1 → NP_001371494.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    3. NM_001384566.1 → NP_001371495.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    4. NM_001384568.1 → NP_001371497.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    5. NM_001384569.1 → NP_001371498.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    6. NM_001384570.1 → NP_001371499.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    7. NM_001384571.1 → NP_001371500.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    8. NM_001384573.1 → NP_001371502.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    9. NM_001384574.2 → NP_001371503.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Related
      ENSP00000484229.1, ENST00000610417.5
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    10. NM_001384575.1 → NP_001371504.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    11. NM_001384576.1 → NP_001371505.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    12. NM_001384577.1 → NP_001371506.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    13. NM_001384578.1 → NP_001371507.1  protein Smaug homolog 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    14. NM_001384580.1 → NP_001371509.1  protein Smaug homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS77295.1
      UniProtKB/TrEMBL
      M0QZ22, Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    15. NM_001384581.1 → NP_001371510.1  protein Smaug homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS77295.1
      UniProtKB/TrEMBL
      M0QZ22, Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    16. NM_001384582.1 → NP_001371511.1  protein Smaug homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS77295.1
      UniProtKB/TrEMBL
      M0QZ22, Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    17. NM_001384583.1 → NP_001371512.1  protein Smaug homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS77295.1
      UniProtKB/TrEMBL
      M0QZ22, Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    18. NM_001384584.1 → NP_001371513.1  protein Smaug homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR compared to variant 2. Variants 2 and 15-19 all encode the same isoform (b).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS77295.1
      UniProtKB/TrEMBL
      M0QZ22, Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    19. NM_001384585.1 → NP_001371514.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) encodes isoform c.
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    20. NM_001384586.1 → NP_001371515.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    21. NM_001384587.1 → NP_001371516.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    22. NM_001384588.1 → NP_001371517.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    23. NM_001384589.1 → NP_001371518.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    24. NM_001384590.1 → NP_001371519.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    25. NM_001384591.1 → NP_001371520.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    26. NM_001384592.1 → NP_001371521.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    27. NM_001384593.1 → NP_001371522.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    28. NM_001384594.1 → NP_001371523.1  protein Smaug homolog 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29) differs in the 5' UTR compared to variant 20. Variants 20-29 all encode the same isoform (c).
      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    29. NM_001384595.1 → NP_001371524.1  protein Smaug homolog 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC005239, AC011445
      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    30. NM_018028.4 → NP_060498.2  protein Smaug homolog 2 isoform a

      See identical proteins and their annotated locations for NP_060498.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 3-14 all encode the same isoform (a).
      Source sequence(s)
      AC005239, AC011445
      Consensus CDS
      CCDS33020.1
      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194
      UniProtKB/TrEMBL
      Q66K25
      Related
      ENSP00000317224.5, ENST00000314471.10
      Conserved Domains (1) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily

    RNA

    1. NR_169271.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005239, AC011445

    2. NR_169272.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005239, AC011445

    3. NR_169273.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005239, AC011445

    4. NR_169274.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005239, AC011445

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39342421..39390764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026919.2 → XP_016882408.1  protein Smaug homolog 2 isoform X1

      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (2) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily
      smart00454
      Location:301 → 359
      SAM; Sterile alpha motif

    2. XM_047439027.1 → XP_047294983.1  protein Smaug homolog 2 isoform X1

    3. XM_011527057.3 → XP_011525359.1  protein Smaug homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011525359.1

      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (2) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily
      smart00454
      Location:301 → 359
      SAM; Sterile alpha motif

    4. XM_011527062.3 → XP_011525364.1  protein Smaug homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011525364.1

      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (2) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily
      smart00454
      Location:301 → 359
      SAM; Sterile alpha motif

    5. XM_047439028.1 → XP_047294984.1  protein Smaug homolog 2 isoform X1

    6. XM_047439030.1 → XP_047294986.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    7. XM_047439031.1 → XP_047294987.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    8. XM_047439029.1 → XP_047294985.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    9. XM_047439035.1 → XP_047294991.1  protein Smaug homolog 2 isoform X2

      UniProtKB/TrEMBL
      M0QZ22

    10. XM_047439034.1 → XP_047294990.1  protein Smaug homolog 2 isoform X2

      UniProtKB/TrEMBL
      M0QZ22

    11. XM_011527060.4 → XP_011525362.1  protein Smaug homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011525362.1

      UniProtKB/TrEMBL
      Q66K25
      Conserved Domains (2) summary
      cd09557
      Location:296 → 358
      SAM_Smaug; SAM domain of Smaug subfamily
      smart00454
      Location:301 → 359
      SAM; Sterile alpha motif

    12. XM_047439033.1 → XP_047294989.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    13. XM_047439032.1 → XP_047294988.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    14. XM_047439036.1 → XP_047294992.1  protein Smaug homolog 2 isoform X2

      UniProtKB/TrEMBL
      M0QZ22

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791808.1 Reference GRCh38.p14 PATCHES

      Range
      122803..137509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42146695..42195044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321350.1 → XP_054177325.1  protein Smaug homolog 2 isoform X1

    2. XM_054321351.1 → XP_054177326.1  protein Smaug homolog 2 isoform X1

    3. XM_054321349.1 → XP_054177324.1  protein Smaug homolog 2 isoform X1

    4. XM_054321352.1 → XP_054177327.1  protein Smaug homolog 2 isoform X1

    5. XM_054321353.1 → XP_054177328.1  protein Smaug homolog 2 isoform X1

    6. XM_054321355.1 → XP_054177330.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    7. XM_054321354.1 → XP_054177329.1  protein Smaug homolog 2 isoform X2

      UniProtKB/Swiss-Prot
      A5Z0M6, Q5PRF9, Q6P194

    8. XM_054321356.1 → XP_054177331.1  protein Smaug homolog 2 isoform X2

      UniProtKB/TrEMBL
      M0QZ22
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PRF9.1 GenPept UniProtKB/Swiss-Prot:Q5PRF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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